Gene description for BRCA2
Gene name	breast cancer 2, early onset
Gene symbol	BRCA2
Other names/aliases	BRCC2 BROVCA2 FACD FAD FAD1 FANCD FANCD1 GLM3 PNCA2 XRCC11
Species	Homo sapiens
Database cross references - BRCA2
ExoCarta	ExoCarta_675
Vesiclepedia	VP_675
Entrez Gene	675
HGNC	1101
MIM	600185
UniProt	P51587
BRCA2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for BRCA2

Molecular Function     protease binding GO:0002020 IPI     single-stranded DNA binding GO:0003697 IDA     histone acetyltransferase activity GO:0004402 IDA     protein binding GO:0005515 IDA     protein binding GO:0005515 IPI     histone H3 acetyltransferase activity GO:0010484 IDA     histone H4 acetyltransferase activity GO:0010485 IDA     identical protein binding GO:0042802 IPI     gamma-tubulin binding GO:0043015 IPI Biological Process     telomere maintenance via recombination GO:0000722 IEA     double-strand break repair via homologous recombination GO:0000724 IBA     double-strand break repair via homologous recombination GO:0000724 IDA     double-strand break repair via homologous recombination GO:0000724 IMP     oocyte maturation GO:0001556 IEA     inner cell mass cell proliferation GO:0001833 IEA     nucleotide-excision repair GO:0006289 IMP     double-strand break repair GO:0006302 IMP     chromatin remodeling GO:0006338 IEA     regulation of DNA-templated transcription GO:0006355 IBA     DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IEA     male meiosis I GO:0007141 IEA     spermatogenesis GO:0007283 IEA     brain development GO:0007420 IEA     female gonad development GO:0008585 IEA     response to X-ray GO:0010165 IEA     response to UV-C GO:0010225 IEA     response to gamma radiation GO:0010332 IEA     regulation of cytokinesis GO:0032465 IEA     negative regulation of mammary gland epithelial cell proliferation GO:0033600 IDA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IEA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of mitotic cell cycle GO:0045931 IEA     centrosome duplication GO:0051298 IMP     establishment of protein localization to telomere GO:0070200 IDA     hematopoietic stem cell proliferation GO:0071425 IEA     cellular response to ionizing radiation GO:0071479 IMP     cellular senescence GO:0090398 IEA     mitotic recombination-dependent replication fork processing GO:1990426 IMP     regulation of DNA damage checkpoint GO:2000001 NAS Subcellular Localization     nuclear ubiquitin ligase complex GO:0000152 IDA     chromosome, telomeric region GO:0000781 IDA     lateral element GO:0000800 IDA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     centrosome GO:0005813 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     secretory granule GO:0030141 IDA     protein-containing complex GO:0032991 IDA     BRCA2-MAGE-D1 complex GO:0033593 IDA     DNA repair complex GO:1990391 IPI