Gene description for SMAD3
Gene name SMAD family member 3
Gene symbol SMAD3
Other names/aliases HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
Species Homo sapiens
 Database cross references - SMAD3
ExoCarta ExoCarta_4088
Vesiclepedia VP_4088
Entrez Gene 4088
HGNC 6769
MIM 603109
UniProt P84022  
 SMAD3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SMAD3
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IC
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IMP
    DNA-binding transcription repressor activity GO:0001217 IDA
    transcription corepressor binding GO:0001222 IPI
    transcription coactivator binding GO:0001223 IPI
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISS
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    DNA-binding transcription factor activity GO:0003700 IMP
    transforming growth factor beta receptor binding GO:0005160 IPI
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IEA
    beta-catenin binding GO:0008013 IEA
    zinc ion binding GO:0008270 IDA
    nuclear receptor binding GO:0016922 IPI
    DEAD/H-box RNA helicase binding GO:0017151 IPI
    protein kinase binding GO:0019901 IPI
    phosphatase binding GO:0019902 IPI
    chromatin DNA binding GO:0031490 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    nuclear mineralocorticoid receptor binding GO:0031962 IPI
    sterol response element binding GO:0032810 IGI
    nuclear glucocorticoid receptor binding GO:0035259 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    ubiquitin binding GO:0043130 IDA
    bHLH transcription factor binding GO:0043425 IPI
    sequence-specific DNA binding GO:0043565 IDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    co-SMAD binding GO:0070410 IPI
    I-SMAD binding GO:0070411 IBA
    R-SMAD binding GO:0070412 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
    promoter-specific chromatin binding GO:1990841 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    ureteric bud development GO:0001657 IEA
    response to hypoxia GO:0001666 IMP
    in utero embryonic development GO:0001701 IEA
    mesoderm formation GO:0001707 IEA
    somitogenesis GO:0001756 IEA
    liver development GO:0001889 IEA
    heart looping GO:0001947 IEA
    osteoblast development GO:0002076 IEA
    immune system development GO:0002520 IEA
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    immune response GO:0006955 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 NAS
    JNK cascade GO:0007254 IEA
    endoderm development GO:0007492 IEA
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IMP
    anatomical structure morphogenesis GO:0009653 IBA
    embryonic pattern specification GO:0009880 IEA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of gene expression GO:0010629 IMP
    positive regulation of epithelial to mesenchymal transition GO:0010718 IDA
    positive regulation of epithelial to mesenchymal transition GO:0010718 IMP
    regulation of striated muscle tissue development GO:0016202 IEA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IEA
    signal transduction involved in regulation of gene expression GO:0023019 IEA
    cell differentiation GO:0030154 IBA
    negative regulation of ossification GO:0030279 IDA
    negative regulation of cell growth GO:0030308 IDA
    adrenal gland development GO:0030325 IEA
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of bone mineralization GO:0030501 IEA
    thyroid gland development GO:0030878 IEA
    primary miRNA processing GO:0031053 TAS
    positive regulation of chondrocyte differentiation GO:0032332 IEA
    positive regulation of interleukin-1 beta production GO:0032731 IEA
    regulation of transforming growth factor beta2 production GO:0032909 IMP
    positive regulation of transforming growth factor beta3 production GO:0032916 IEA
    activin receptor signaling pathway GO:0032924 IBA
    activin receptor signaling pathway GO:0032924 IMP
    activin receptor signaling pathway GO:0032924 NAS
    negative regulation of osteoblast proliferation GO:0033689 IEA
    nodal signaling pathway GO:0038092 IMP
    wound healing GO:0042060 TAS
    T cell activation GO:0042110 IEA
    negative regulation of protein catabolic process GO:0042177 IEA
    positive regulation of protein import into nucleus GO:0042307 NAS
    negative regulation of apoptotic process GO:0043066 IEA
    cell-cell junction organization GO:0045216 IMP
    positive regulation of nitric oxide biosynthetic process GO:0045429 IDA
    negative regulation of fat cell differentiation GO:0045599 IDA
    negative regulation of osteoblast differentiation GO:0045668 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    paraxial mesoderm morphogenesis GO:0048340 IEA
    developmental growth GO:0048589 IEA
    embryonic foregut morphogenesis GO:0048617 IEA
    embryonic cranial skeleton morphogenesis GO:0048701 IEA
    regulation of epithelial cell proliferation GO:0050678 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    regulation of immune response GO:0050776 IEA
    protein stabilization GO:0050821 IEA
    positive regulation of positive chemotaxis GO:0050927 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 NAS
    negative regulation of cytosolic calcium ion concentration GO:0051481 IDA
    positive regulation of stress fiber assembly GO:0051496 IEA
    positive regulation of focal adhesion assembly GO:0051894 IEA
    pericardium development GO:0060039 IEA
    transdifferentiation GO:0060290 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    SMAD protein signal transduction GO:0060395 IBA
    SMAD protein signal transduction GO:0060395 IDA
    SMAD protein signal transduction GO:0060395 IMP
    SMAD protein signal transduction GO:0060395 NAS
    negative regulation of wound healing GO:0061045 IEA
    negative regulation of lung blood pressure GO:0061767 IEA
    lens fiber cell differentiation GO:0070306 IEA
    cellular response to glucose stimulus GO:0071333 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    apoptotic signaling pathway GO:0097190 IMP
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    cellular response to virus GO:0098586 IEA
    positive regulation of extracellular matrix assembly GO:1901203 IDA
    positive regulation of extracellular matrix assembly GO:1901203 IMP
    regulation of miRNA transcription GO:1902893 IC
    negative regulation of miRNA transcription GO:1902894 IMP
    positive regulation of miRNA transcription GO:1902895 IDA
    positive regulation of miRNA transcription GO:1902895 IMP
    positive regulation of miRNA transcription GO:1902895 IMP
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 IEA
    response to angiotensin GO:1990776 IMP
Subcellular Localization
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IGI
    nuclear inner membrane GO:0005637 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    transcription regulator complex GO:0005667 IPI
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IGI
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    receptor complex GO:0043235 IMP
    SMAD protein complex GO:0071141 IDA
    heteromeric SMAD protein complex GO:0071144 IBA
    heteromeric SMAD protein complex GO:0071144 IDA
    heteromeric SMAD protein complex GO:0071144 NAS
 Experiment description of studies that identified SMAD3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMAD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Co-fractionation Homo sapiens
2 HDAC4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 AATF  
Two-hybrid Homo sapiens
4 SKI 6497
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 ZC3H12A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 TGM2 7052
Two-hybrid Homo sapiens
9 SNRNP70 6625
Two-hybrid Homo sapiens
10 MTF2  
Two-hybrid Homo sapiens
11 NUP153 9972
Reconstituted Complex Homo sapiens
12 C10orf54 64115
Two-hybrid Homo sapiens
13 CPSF7 79869
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 RGCC 28984
Affinity Capture-Western Homo sapiens
15 ZMYND11 10771
Two-hybrid Homo sapiens
16 NCOA3  
Affinity Capture-MS Homo sapiens
17 USP33  
Affinity Capture-MS Homo sapiens
18 UCHL5 51377
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 SMAD5 4090
Affinity Capture-MS Homo sapiens
20 PRTN3 5657
Affinity Capture-Western Homo sapiens
21 BTRC 8945
Affinity Capture-Western Homo sapiens
22 ZFYVE9  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MTA2 9219
Co-fractionation Homo sapiens
24 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 NEDD9 4739
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
26 TCP1 6950
Affinity Capture-MS Homo sapiens
27 ZNF83  
Two-hybrid Homo sapiens
28 PABPC1 26986
Affinity Capture-MS Homo sapiens
29 CDH1 999
Co-fractionation Homo sapiens
30 FOXL2  
Affinity Capture-Western Homo sapiens
31 YAP1 10413
Affinity Capture-Western Homo sapiens
32 C1orf116 79098
Affinity Capture-MS Homo sapiens
33 GMEB1  
Two-hybrid Homo sapiens
34 BMP7 655
Co-localization Homo sapiens
35 MEOX2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 MAPK8 5599
Co-localization Homo sapiens
37 TMED1 11018
Two-hybrid Homo sapiens
38 MED15  
Affinity Capture-Western Homo sapiens
39 SQRDL 58472
Affinity Capture-MS Homo sapiens
40 FOXH1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
41 EIF4B 1975
Reconstituted Complex Homo sapiens
42 PAX6  
Affinity Capture-Western Homo sapiens
43 RELA 5970
Two-hybrid Homo sapiens
44 PLAGL1  
Two-hybrid Homo sapiens
45 EPAS1  
Co-localization Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
46 ERBB2IP 55914
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 PIAS2  
Reconstituted Complex Homo sapiens
48 TEKT4  
Two-hybrid Homo sapiens
49 FOXO1  
Affinity Capture-Western Homo sapiens
50 Dok1  
Affinity Capture-Western Mus musculus
51 RUNX3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 STRAP 11171
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
53 CYP11A1  
Two-hybrid Homo sapiens
54 ETS1  
Co-localization Homo sapiens
55 HSPA4 3308
Affinity Capture-MS Homo sapiens
56 AKT1 207
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
57 GRIP1  
Affinity Capture-Western Homo sapiens
58 CAMK2G 818
Co-localization Homo sapiens
59 STUB1 10273
Reconstituted Complex Homo sapiens
60 DNMT3L  
Reconstituted Complex Homo sapiens
61 DVL1 1855
Reconstituted Complex Homo sapiens
62 TANK 10010
Two-hybrid Homo sapiens
63 DAB2 1601
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
64 SKIL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 CDK8 1024
Biochemical Activity Homo sapiens
66 KMT2B  
Two-hybrid Homo sapiens
67 Fbxo3  
Affinity Capture-Luminescence Mus musculus
68 ZEB1  
Affinity Capture-Western Homo sapiens
69 Rras2 66922
Affinity Capture-Luminescence Mus musculus
70 WWP2 11060
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
71 DDX3X 1654
Affinity Capture-MS Homo sapiens
72 Sox9  
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
73 APOB 338
Two-hybrid Homo sapiens
74 CEBPB  
Reconstituted Complex Homo sapiens
75 SNW1 22938
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
76 NFIC 4782
Affinity Capture-Western Homo sapiens
77 SMURF2 64750
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
78 BLZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 NCOA6  
Two-hybrid Homo sapiens
80 ST6GALNAC2  
Two-hybrid Homo sapiens
81 UCHL1 7345
Affinity Capture-Western Homo sapiens
82 JUND 3727
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
83 TRIM33 51592
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
84 RNMT 8731
Co-fractionation Homo sapiens
85 PLG 5340
Two-hybrid Homo sapiens
86 Wee1  
Affinity Capture-Luminescence Mus musculus
87 YTHDF2 51441
Affinity Capture-MS Homo sapiens
88 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
89 S100A4 6275
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
90 ZMIZ1 57178
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
91 TCF12  
Affinity Capture-Western Homo sapiens
92 HEY1  
Two-hybrid Homo sapiens
93 Rgs3  
Affinity Capture-Luminescence Mus musculus
94 UGT1A10  
Affinity Capture-MS Homo sapiens
95 GGA1 26088
Two-hybrid Homo sapiens
96 TMEM192 201931
Affinity Capture-MS Homo sapiens
97 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 CUL1 8454
Affinity Capture-Western Homo sapiens
99 USP7 7874
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
100 GSK3B 2932
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
101 Wwp2  
Affinity Capture-Luminescence Mus musculus
102 HOXC11  
Two-hybrid Homo sapiens
103 KANSL1  
Two-hybrid Homo sapiens
104 RUNX1  
Affinity Capture-Western Homo sapiens
105 RBX1 9978
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
106 FBLN1 2192
Two-hybrid Homo sapiens
107 CDKN1A  
Affinity Capture-Western Homo sapiens
108 RPL4 6124
Affinity Capture-MS Homo sapiens
109 ZBTB16  
Two-hybrid Homo sapiens
110 BACH1 571
Affinity Capture-Western Homo sapiens
111 TRIM24  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 CFDP1  
Two-hybrid Homo sapiens
113 ZEB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
114 NFIA 4774
Reconstituted Complex Homo sapiens
115 DCAF7 10238
Affinity Capture-MS Homo sapiens
116 BPTF 2186
Reconstituted Complex Homo sapiens
117 APMAP 57136
Two-hybrid Homo sapiens
118 SRY  
Affinity Capture-Western Homo sapiens
119 RPLP0 6175
Two-hybrid Homo sapiens
120 SS18L1  
Two-hybrid Homo sapiens
121 Ppp2r2d  
Affinity Capture-Luminescence Mus musculus
122 CDK4 1019
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
123 Rnf111  
Affinity Capture-Western Mus musculus
124 FURIN 5045
Affinity Capture-MS Homo sapiens
125 USP15 9958
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
126 PPARG 5468
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 SETD2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
128 DACH1  
Affinity Capture-Western Homo sapiens
129 Arhgef6  
Affinity Capture-Luminescence Mus musculus
130 SPTBN1 6711
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
131 SMAD1 4086
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
132 RANBP9 10048
Two-hybrid Homo sapiens
133 CDK2 1017
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
134 FAM90A1  
Two-hybrid Homo sapiens
135 PPP2R1A 5518
Two-hybrid Homo sapiens
136 JAK1 3716
Positive Genetic Homo sapiens
137 CHRD  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
138 Arhgef7  
Affinity Capture-Luminescence Mus musculus
139 PARP4 143
Two-hybrid Homo sapiens
140 Yap1  
Reconstituted Complex Mus musculus
141 MECOM 2122
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
142 LEMD3  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 MCM3AP  
Two-hybrid Homo sapiens
144 ZNF329  
Two-hybrid Homo sapiens
145 PARP1 142
Co-fractionation Homo sapiens
146 SMAD7  
Phenotypic Suppression Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
147 MAX  
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
148 CRX  
Two-hybrid Homo sapiens
149 HEYL  
Two-hybrid Homo sapiens
150 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
151 SMAD4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
152 OTUB1 55611
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
153 BUB3 9184
Affinity Capture-MS Homo sapiens
154 HNRNPK 3190
Two-hybrid Homo sapiens
155 ESR1  
Affinity Capture-Western Homo sapiens
156 TFE3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
157 RIOK2 55781
Two-hybrid Homo sapiens
158 LBP 3929
Two-hybrid Homo sapiens
159 DNAJB4 11080
Two-hybrid Homo sapiens
160 TRIB3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
161 KAT6A  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
162 ANK3  
Two-hybrid Homo sapiens
163 PHC2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
164 MYC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
165 CFH 3075
Two-hybrid Homo sapiens
166 ZNF774  
Two-hybrid Homo sapiens
167 KDM5C  
Affinity Capture-Western Homo sapiens
168 PITX2  
Affinity Capture-Western Homo sapiens
169 RCVRN  
Two-hybrid Homo sapiens
170 SP1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
171 EPB41L5 57669
Affinity Capture-MS Homo sapiens
172 Smad2  
Affinity Capture-Luminescence Mus musculus
173 RPSAP15 220885
Affinity Capture-MS Homo sapiens
174 MED24 9862
Affinity Capture-Western Homo sapiens
175 SOX9  
Affinity Capture-Western Homo sapiens
176 FOXO4  
Affinity Capture-Western Homo sapiens
177 NOTCH4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 PJA1  
Affinity Capture-MS Homo sapiens
179 CDC16 8881
Affinity Capture-Western Homo sapiens
180 KDM2A  
Two-hybrid Homo sapiens
181 SUV39H1  
Affinity Capture-Western Homo sapiens
182 CDC25A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
183 PROX1  
Two-hybrid Homo sapiens
184 LEF1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
185 ATG16L1 55054
Affinity Capture-MS Homo sapiens
186 DDX4 54514
Affinity Capture-MS Homo sapiens
187 VDR  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
188 CEBPD  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
189 UBQLN4 56893
Two-hybrid Homo sapiens
190 CFLAR  
Two-hybrid Homo sapiens
191 Clasrp  
Affinity Capture-Luminescence Mus musculus
192 NCOA1  
Affinity Capture-Western Homo sapiens
193 NF2 4771
Affinity Capture-MS Homo sapiens
194 PARK2  
Affinity Capture-MS Homo sapiens
195 IGF1R 3480
Co-fractionation Homo sapiens
196 FAM83G  
Affinity Capture-MS Homo sapiens
197 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
198 GIT2 9815
Two-hybrid Homo sapiens
199 LRCH1 23143
Affinity Capture-MS Homo sapiens
200 Map2k3  
Affinity Capture-Luminescence Mus musculus
201 U2AF2 11338
Affinity Capture-MS Homo sapiens
202 PLAG1  
Two-hybrid Homo sapiens
203 SERTAD1  
Two-hybrid Homo sapiens
204 SMAD2 4087
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 NFYC 4802
Affinity Capture-Western Homo sapiens
206 ACTB 60
Affinity Capture-Western Homo sapiens
207 VAV2 7410
Affinity Capture-MS Homo sapiens
208 ISL1  
Two-hybrid Homo sapiens
209 ATF3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
210 RBL1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
211 FLI1  
Two-hybrid Homo sapiens
212 SLC25A12 8604
Affinity Capture-MS Homo sapiens
213 SIK3 23387
Affinity Capture-MS Homo sapiens
214 PCDH1 5097
Two-hybrid Homo sapiens
215 EID2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
216 NR3C1 2908
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
217 YY1 7528
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
218 TGFB1I1 7041
Affinity Capture-Western Homo sapiens
219 NUP214 8021
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
220 MAP3K7  
Co-localization Homo sapiens
221 Rab38  
Affinity Capture-Luminescence Mus musculus
222 HNF4A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
223 LACRT 90070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
224 PSPC1 55269
Affinity Capture-MS Homo sapiens
225 SMAD9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
226 RUNX2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
227 ITGB4 3691
Affinity Capture-MS Homo sapiens
228 JUNB  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
229 CORO1A 11151
Two-hybrid Homo sapiens
230 RBBP5 5929
Affinity Capture-Western Homo sapiens
231 TLR4  
Two-hybrid Homo sapiens
232 CHUK 1147
Affinity Capture-Western Homo sapiens
233 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
234 XRCC5 7520
Co-fractionation Homo sapiens
235 CSH2  
Two-hybrid Homo sapiens
236 HIF1A 3091
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
237 DZIP3  
Affinity Capture-MS Homo sapiens
238 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
239 FOXO3  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
240 MYOCD  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
241 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
242 SIN3A  
Reconstituted Complex Homo sapiens
243 LSR 51599
Affinity Capture-MS Homo sapiens
244 Sin3a  
Reconstituted Complex Mus musculus
245 PIN1 5300
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
246 RNF31 55072
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
247 KAT2B  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
248 RPA1 6117
Two-hybrid Homo sapiens
249 MEN1 4221
Affinity Capture-Western Homo sapiens
250 CREBBP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
251 Trim35  
Affinity Capture-Luminescence Mus musculus
252 OVOL2  
Affinity Capture-Western Homo sapiens
253 DDX58 23586
Affinity Capture-RNA Homo sapiens
254 KDM6B 23135
Affinity Capture-Western Homo sapiens
255 HDAC5 10014
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
256 TGIF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
257 HP 3240
Two-hybrid Homo sapiens
258 FLNA 2316
Two-hybrid Homo sapiens
259 MYD88 4615
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
260 RNF111 54778
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
261 FOXM1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
262 EVA1B 55194
Affinity Capture-MS Homo sapiens
263 AR 367
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
264 NOTCH1 4851
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
265 CDK11A 728642
Affinity Capture-MS Homo sapiens
266 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
267 MAFK 7975
Affinity Capture-Western Homo sapiens
268 WWP1 11059
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
269 MKL1 57591
Affinity Capture-Western Homo sapiens
270 PPIE 10450
Affinity Capture-MS Homo sapiens
271 PSMD11 5717
Two-hybrid Homo sapiens
272 MED6  
Affinity Capture-Western Homo sapiens
273 CSNK1G2 1455
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
274 KPNB1 3837
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
275 DHX8 1659
Affinity Capture-MS Homo sapiens
276 DDX3Y 8653
Affinity Capture-MS Homo sapiens
277 USP9X 8239
Affinity Capture-Western Homo sapiens
278 TRIM62  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
279 APP 351
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
280 ZBTB3  
Two-hybrid Homo sapiens
281 TSC22D4 81628
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
282 DYRK1A 1859
Affinity Capture-MS Homo sapiens
283 TGFB1 7040
Affinity Capture-MS Homo sapiens
284 ATXN2L 11273
Affinity Capture-MS Homo sapiens
285 HGS 9146
Affinity Capture-Western Homo sapiens
286 PRDM4  
Two-hybrid Homo sapiens
287 TDP2 51567
Two-hybrid Homo sapiens
288 CDC27 996
Affinity Capture-Western Homo sapiens
289 HINT3 135114
Affinity Capture-MS Homo sapiens
290 USP2  
Affinity Capture-Western Homo sapiens
291 CSNK1D 1453
Affinity Capture-MS Homo sapiens
292 NEDD4 4734
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
293 CTCF  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
294 MAPK1 5594
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
295 E2F4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
296 PCK2 5106
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
297 ANAPC10  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
298 CXXC5  
Two-hybrid Homo sapiens
299 PIAS4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
300 HIVEP1 3096
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
301 ATF2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
302 BRCA2 675
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
303 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
304 ACVR1B 91
Affinity Capture-Western Homo sapiens
305 PRDM16 63976
Affinity Capture-Western Homo sapiens
306 SREBF2 6721
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
307 DDX5 1655
Reconstituted Complex Homo sapiens
308 SMAD3 4088
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
309 Gsc  
Affinity Capture-Luminescence Mus musculus
310 OPA1 4976
Affinity Capture-MS Homo sapiens
311 SBK3  
Two-hybrid Homo sapiens
312 Sqstm1  
Affinity Capture-Luminescence Mus musculus
313 PML 5371
Affinity Capture-Western Homo sapiens
314 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
315 ITCH 83737
Reconstituted Complex Homo sapiens
316 CEBPA  
Reconstituted Complex Homo sapiens
317 PPP1R12C 54776
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
318 EBI3 10148
Two-hybrid Homo sapiens
319 SMARCC2 6601
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
320 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
321 NR4A1  
Two-hybrid Homo sapiens
322 PTPN6 5777
Affinity Capture-MS Homo sapiens
323 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
324 Smad3  
Affinity Capture-MS Mus musculus
Affinity Capture-Luminescence Mus musculus
325 CD6 923
Affinity Capture-MS Homo sapiens
326 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
327 RPL3 6122
Affinity Capture-MS Homo sapiens
328 ELAC2 60528
Affinity Capture-Western Homo sapiens
329 PIAS3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
330 XPO6 23214
Reconstituted Complex Homo sapiens
331 JUN 3725
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
332 FOS 2353
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
333 Zfp128  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
334 CITED2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
335 CHD8 57680
Affinity Capture-MS Homo sapiens
336 ARID1A 8289
Affinity Capture-MS Homo sapiens
337 TOB1  
Affinity Capture-Western Homo sapiens
338 MDM4  
Reconstituted Complex Homo sapiens
339 DOCK9 23348
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
340 SVEP1 79987
Two-hybrid Homo sapiens
341 ZCCHC14 23174
Two-hybrid Homo sapiens
342 KAT2A  
Affinity Capture-Western Homo sapiens
343 SAP130  
Two-hybrid Homo sapiens
344 TGIF2  
Affinity Capture-Western Homo sapiens
345 DNAJA2 10294
Affinity Capture-MS Homo sapiens
346 SMARCC1 6599
Affinity Capture-MS Homo sapiens
347 PITX1  
Affinity Capture-Western Homo sapiens
348 SMURF1 57154
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
349 HDAC1 3065
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
350 TF 7018
Two-hybrid Homo sapiens
351 Rasd2  
Affinity Capture-Luminescence Mus musculus
352 PAPPA 5069
Two-hybrid Homo sapiens
353 TRIP4 9325
Affinity Capture-MS Homo sapiens
354 CDK9 1025
Biochemical Activity Homo sapiens
355 KCTD16  
Affinity Capture-MS Homo sapiens
356 XRCC6 2547
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
357 HIPK2 28996
Reconstituted Complex Homo sapiens
358 IRS1 3667
Affinity Capture-MS Homo sapiens
359 ZFP69B  
Affinity Capture-MS Homo sapiens
360 CPTP  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SMAD3 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Deubiquitination TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
Downregulation of TGF-beta receptor signaling TAS Reactome
Formation of axial mesoderm IEA Reactome
Formation of definitive endoderm IEA Reactome
Formation of definitive endoderm TAS Reactome
FOXO-mediated transcription IEA Reactome
FOXO-mediated transcription TAS Reactome
FOXO-mediated transcription of cell cycle genes IEA Reactome
FOXO-mediated transcription of cell cycle genes TAS Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes IEA Reactome
Gastrulation IEA Reactome
Gastrulation TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
Germ layer formation at gastrulation IEA Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-37 signaling TAS Reactome
Loss of Function of SMAD2/3 in Cancer TAS Reactome
Loss of Function of SMAD4 in Cancer TAS Reactome
Loss of Function of TGFBR1 in Cancer TAS Reactome
Metabolism of proteins TAS Reactome
NOTCH4 Intracellular Domain Regulates Transcription IEA Reactome
Post-translational protein modification TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX3 regulates BCL2L11 (BIM) transcription TAS Reactome
RUNX3 regulates CDKN1A transcription TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1 targets host intracellular signalling and regulatory pathways TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Activin TAS Reactome
Signaling by Activin IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by NODAL TAS Reactome
Signaling by NODAL IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGF-beta Receptor Complex in Cancer TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFB family members IEA Reactome
Signaling by TGFBR3 TAS Reactome
SMAD2/3 MH2 Domain Mutants in Cancer TAS Reactome
SMAD2/3 Phosphorylation Motif Mutants in Cancer TAS Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TAS Reactome
SMAD4 MH2 Domain Mutants in Cancer TAS Reactome
TGF-beta receptor signaling activates SMADs TAS Reactome
TGFBR1 KD Mutants in Cancer TAS Reactome
TGFBR3 expression TAS Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IEA Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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