Gene description for SNCA
Gene name synuclein, alpha (non A4 component of amyloid precursor)
Gene symbol SNCA
Other names/aliases NACP
PARK1
PARK4
PD1
Species Homo sapiens
 Database cross references - SNCA
ExoCarta ExoCarta_6622
Entrez Gene 6622
HGNC 11138
MIM 163890
UniProt P37840  
 SNCA identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SNCA
Molecular Function
    microtubule binding GO:0008017 IEA
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA
    phosphoprotein binding GO:0051219 IDA
    zinc ion binding GO:0008270 IDA
    dynein binding GO:0045502 IPI
    beta-tubulin binding GO:0048487 IEA
    transcription regulatory region DNA binding GO:0044212 TAS
    identical protein binding GO:0042802 IPI
    alpha-tubulin binding GO:0043014 IPI
    tau protein binding GO:0048156 IDA
    ferrous iron binding GO:0008198 IDA
    oxidoreductase activity GO:0016491 IDA
    histone binding GO:0042393 IDA
    magnesium ion binding GO:0000287 IDA
    protein binding GO:0005515 IPI
    Hsp70 protein binding GO:0030544 IPI
    kinesin binding GO:0019894 IPI
    phospholipase D inhibitor activity GO:0060961 IDA
    phospholipase binding GO:0043274 IEA
    calcium ion binding GO:0005509 IDA
    copper ion binding GO:0005507 IDA
    protein N-terminus binding GO:0047485 IEA
    fatty acid binding GO:0005504 IDA
    phospholipid binding GO:0005543 IDA
    protein domain specific binding GO:0019904 IEA
Biological Process
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    oxidation-reduction process GO:0055114 IDA
    dopamine biosynthetic process GO:0042416 TAS
    positive regulation of receptor recycling GO:0001921 IDA
    negative regulation of serotonin uptake GO:0051612 IDA
    dopamine uptake involved in synaptic transmission GO:0051583 TAS
    long-term synaptic potentiation GO:0060291 IEA
    response to lipopolysaccharide GO:0032496 IDA
    negative regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902957 TAS
    regulation of reactive oxygen species biosynthetic process GO:1903426 TAS
    behavioral response to cocaine GO:0048148 IEA
    mitochondrial membrane organization GO:0007006 IEA
    regulation of dopamine secretion GO:0014059 TAS
    negative regulation of neuron apoptotic process GO:0043524 IEA
    synapse organization GO:0050808 IEA
    response to interleukin-1 GO:0070555 IDA
    positive regulation of inositol phosphate biosynthetic process GO:0060732 IDA
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    negative regulation of microtubule polymerization GO:0031115 IDA
    extracellular fibril organization GO:0043206 TAS
    negative regulation of thrombin receptor signaling pathway GO:0070495 IDA
    positive regulation of neurotransmitter secretion GO:0001956 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS
    response to magnesium ion GO:0032026 IDA
    negative regulation of dopamine uptake involved in synaptic transmission GO:0051585 IDA
    response to drug GO:0042493 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of glutathione peroxidase activity GO:1903284 IDA
    cellular response to oxidative stress GO:0034599 IC
    cellular response to fibroblast growth factor stimulus GO:0044344 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IDA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IMP
    negative regulation of exocytosis GO:0045920 IMP
    cellular response to copper ion GO:0071280 IDA
    regulation of macrophage activation GO:0043030 IEA
    regulation of locomotion GO:0040012 IEA
    negative regulation of protein phosphorylation GO:0001933 IEA
    regulation of synaptic vesicle recycling GO:1903421 TAS
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IDA
    microglial cell activation GO:0001774 TAS
    regulation of acyl-CoA biosynthetic process GO:0050812 IEA
    neutral lipid metabolic process GO:0006638 IEA
    negative regulation of transporter activity GO:0032410 IDA
    adult locomotory behavior GO:0008344 IEA
    regulation of phospholipase activity GO:0010517 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISS
    aging GO:0007568 IEA
    positive regulation of apoptotic process GO:0043065 TAS
    regulation of glutamate secretion GO:0014048 IEA
    calcium ion homeostasis GO:0055074 IDA
    synaptic vesicle endocytosis GO:0048488 ISS
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA
    protein destabilization GO:0031648 IDA
    positive regulation of endocytosis GO:0045807 IDA
    negative regulation of dopamine metabolic process GO:0045963 IEA
    negative regulation of norepinephrine uptake GO:0051622 IDA
    positive regulation of hydrogen peroxide catabolic process GO:1903285 IDA
    cellular response to epinephrine stimulus GO:0071872 TAS
    regulation of long-term neuronal synaptic plasticity GO:0048169 IEA
    negative regulation of monooxygenase activity GO:0032769 IDA
    negative regulation of histone acetylation GO:0035067 IDA
    response to interferon-gamma GO:0034341 IDA
    mitochondrial ATP synthesis coupled electron transport GO:0042775 IEA
    response to iron(II) ion GO:0010040 IDA
    receptor internalization GO:0031623 IDA
    fatty acid metabolic process GO:0006631 IEA
    phospholipid metabolic process GO:0006644 IEA
Subcellular Localization
    rough endoplasmic reticulum GO:0005791 IEA
    mitochondrial respiratory chain complex I GO:0005747 TAS
    Golgi apparatus GO:0005794 IEA
    nucleus GO:0005634 IDA
    extracellular space GO:0005615 IDA
    platelet alpha granule membrane GO:0031092 IDA
    extracellular region GO:0005576 TAS
    cell junction GO:0030054 IEA
    cell cortex GO:0005938 IDA
    ribosome GO:0005840 IEA
    synaptic vesicle GO:0008021 IEA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 TAS
    membrane GO:0016020 IDA
    fibril GO:0043205 IDA
    nuclear outer membrane GO:0005640 IEA
    actin cytoskeleton GO:0015629 IDA
    inclusion body GO:0016234 IDA
    growth cone GO:0030426 IDA
    mitochondrion GO:0005739 TAS
    terminal bouton GO:0043195 IEA
    plasma membrane GO:0005886 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    cytosol GO:0005829 IDA
    axon GO:0030424 IDA
 Experiment description of studies that identified SNCA in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNCA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNCB 6620
Affinity Capture-Western Homo sapiens
2 TOR1A 1861
FRET Homo sapiens
3 BAX 581
Reconstituted Complex Homo sapiens
4 BAD  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
5 CPOX 1371
Invivo Homo sapiens
6 TH  
Invivo Homo sapiens
Invitro Homo sapiens
7 YWHAB 7529
Invivo Homo sapiens
8 MAPK1 5594
Affinity Capture-Western Homo sapiens
9 YWHAE 7531
Invivo Homo sapiens
10 SEPT4  
Affinity Capture-Western Homo sapiens
11 MAPK3 5595
Affinity Capture-Western Homo sapiens
12 SQSTM1 8878
Invivo Homo sapiens
13 SNCAIP  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 CALM1 801
Reconstituted Complex Homo sapiens
15 PARK2  
Invivo Homo sapiens
16 MAP1B 4131
Invitro Homo sapiens
Invivo Homo sapiens
17 CYCS  
Invivo Homo sapiens
Invitro Homo sapiens
18 SEPT2 4735
Affinity Capture-Western Homo sapiens
19 PLD1 5337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 TUBA1A 7846
Invitro Homo sapiens
22 MAPT  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
23 PRKCE  
Invivo Homo sapiens
24 FYN 2534
Biochemical Activity Homo sapiens
25 SLC6A3  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 MAPK8 5599
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SNCA is involved
PathwayEvidenceSource
Amyloids TAS Reactome





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