Gene description for TGFBR1
Gene name transforming growth factor, beta receptor 1
Gene symbol TGFBR1
Other names/aliases AAT5
ACVRLK4
ALK-5
ALK5
ESS1
LDS1
LDS1A
LDS2A
MSSE
SKR4
TGFR-1
tbetaR-I
Species Homo sapiens
 Database cross references - TGFBR1
ExoCarta ExoCarta_7046
Vesiclepedia VP_7046
Entrez Gene 7046
HGNC 11772
MIM 190181
UniProt P36897  
 TGFBR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TGFBR1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 IDA
    transforming growth factor beta receptor activity GO:0005024 IC
    transforming growth factor beta receptor activity GO:0005024 IDA
    transforming growth factor beta receptor activity GO:0005024 IMP
    transforming growth factor beta receptor activity GO:0005024 IMP
    transforming growth factor beta receptor activity, type I GO:0005025 IBA
    transforming growth factor beta receptor activity, type I GO:0005025 IDA
    transforming growth factor beta receptor activity, type I GO:0005025 ISS
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    type II transforming growth factor beta receptor binding GO:0005114 IDA
    type II transforming growth factor beta receptor binding GO:0005114 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    activin receptor activity, type I GO:0016361 IBA
    activin receptor activity, type II GO:0016362 IEA
    growth factor binding GO:0019838 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    SMAD binding GO:0046332 IBA
    SMAD binding GO:0046332 IDA
    SMAD binding GO:0046332 IPI
    metal ion binding GO:0046872 IEA
    activin binding GO:0048185 IBA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 IMP
    transforming growth factor beta binding GO:0050431 IPI
    transforming growth factor beta binding GO:0050431 ISS
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    I-SMAD binding GO:0070411 IPI
    BMP receptor activity GO:0098821 IEA
Biological Process
    skeletal system development GO:0001501 ISS
    in utero embryonic development GO:0001701 ISS
    kidney development GO:0001822 ISS
    blastocyst development GO:0001824 IEA
    epithelial to mesenchymal transition GO:0001837 IDA
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    positive regulation of endothelial cell proliferation GO:0001938 ISS
    lens development in camera-type eye GO:0002088 IEA
    ventricular trabecula myocardium morphogenesis GO:0003222 ISS
    ventricular compact myocardium morphogenesis GO:0003223 ISS
    proepicardium development GO:0003342 ISS
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 IMP
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IC
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IGI
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 ISS
    nervous system development GO:0007399 IBA
    heart development GO:0007507 IBA
    heart development GO:0007507 ISS
    positive regulation of cell population proliferation GO:0008284 IMP
    germ cell migration GO:0008354 ISS
    male gonad development GO:0008584 IEA
    post-embryonic development GO:0009791 IEA
    anterior/posterior pattern specification GO:0009952 ISS
    regulation of gene expression GO:0010468 ISS
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 ISS
    regulation of epithelial to mesenchymal transition GO:0010717 ISS
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISS
    peptidyl-serine phosphorylation GO:0018105 IDA
    collagen fibril organization GO:0030199 ISS
    positive regulation of cell growth GO:0030307 IDA
    positive regulation of cell migration GO:0030335 IDA
    negative regulation of cell migration GO:0030336 IMP
    BMP signaling pathway GO:0030509 IEA
    regulation of protein ubiquitination GO:0031396 IDA
    negative regulation of chondrocyte differentiation GO:0032331 ISS
    activin receptor signaling pathway GO:0032924 IBA
    activin receptor signaling pathway GO:0032924 ISS
    intracellular signal transduction GO:0035556 ISS
    myofibroblast differentiation GO:0036446 IMP
    wound healing GO:0042060 TAS
    endothelial cell activation GO:0042118 ISS
    extracellular structure organization GO:0043062 TAS
    endothelial cell migration GO:0043542 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISS
    filopodium assembly GO:0046847 IEA
    thymus development GO:0048538 ISS
    neuron fate commitment GO:0048663 ISS
    embryonic cranial skeleton morphogenesis GO:0048701 ISS
    skeletal system morphogenesis GO:0048705 ISS
    mesenchymal cell differentiation GO:0048762 ISS
    mesenchymal cell differentiation GO:0048762 TAS
    artery morphogenesis GO:0048844 ISS
    cell motility GO:0048870 IMP
    positive regulation of filopodium assembly GO:0051491 IEA
    positive regulation of stress fiber assembly GO:0051496 ISS
    regulation of cell cycle GO:0051726 TAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    parathyroid gland development GO:0060017 ISS
    roof of mouth development GO:0060021 ISS
    pharyngeal system development GO:0060037 ISS
    regulation of cardiac muscle cell proliferation GO:0060043 ISS
    cardiac epithelial to mesenchymal transition GO:0060317 ISS
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 IGI
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    ventricular septum morphogenesis GO:0060412 ISS
    angiogenesis involved in coronary vascular morphogenesis GO:0060978 ISS
    coronary artery morphogenesis GO:0060982 ISS
    response to cholesterol GO:0070723 IDA
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    vascular endothelial cell proliferation GO:0101023 IBA
    positive regulation of extracellular matrix assembly GO:1901203 IMP
    positive regulation of mesenchymal stem cell proliferation GO:1902462 IGI
    positive regulation of vasculature development GO:1904018 IMP
    positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 ISS
    positive regulation of tight junction disassembly GO:1905075 ISS
    epicardium morphogenesis GO:1905223 ISS
    positive regulation of apoptotic signaling pathway GO:2001235 IDA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    bicellular tight junction GO:0005923 IDA
    cell surface GO:0009986 IDA
    membrane GO:0016020 ISS
    receptor complex GO:0043235 IDA
    membrane raft GO:0045121 IDA
    activin receptor complex GO:0048179 IBA
    transforming growth factor beta ligand-receptor complex GO:0070021 IPI
    transforming growth factor beta ligand-receptor complex GO:0070021 ISS
 Experiment description of studies that identified TGFBR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TGFBR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Csnk1d  
Affinity Capture-Luminescence Mus musculus
2 Enc1  
Affinity Capture-Luminescence Mus musculus
3 Wdr13  
Affinity Capture-Luminescence Mus musculus
4 AP2B1 163
Affinity Capture-Western Homo sapiens
5 Ppp3cc  
Affinity Capture-Luminescence Mus musculus
6 Ubb 22187
Affinity Capture-Luminescence Mus musculus
7 OCLN 100506658
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
8 Stk35  
Affinity Capture-Luminescence Mus musculus
9 Rrh  
Affinity Capture-Luminescence Mus musculus
10 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 Anapc5 59008
Affinity Capture-Luminescence Mus musculus
12 SKI 6497
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 IL20RB  
Affinity Capture-MS Homo sapiens
14 Rhebl1  
Affinity Capture-Luminescence Mus musculus
15 Stub1 56424
Affinity Capture-Luminescence Mus musculus
16 MYOC 4653
Two-hybrid Homo sapiens
17 Cdk4  
Affinity Capture-Luminescence Mus musculus
18 Tssk5  
Affinity Capture-Luminescence Mus musculus
19 ECEL1  
Affinity Capture-MS Homo sapiens
20 TMEM9B 56674
Affinity Capture-MS Homo sapiens
21 USP11 8237
Affinity Capture-Western Homo sapiens
22 Csnk1a1 93687
Affinity Capture-Luminescence Mus musculus
23 KLRB1  
Affinity Capture-MS Homo sapiens
24 SNX6 58533
Affinity Capture-Western Homo sapiens
25 FBXO34  
Affinity Capture-Western Homo sapiens
26 Ppp1ca 19045
Affinity Capture-Luminescence Mus musculus
27 Sntg1  
Affinity Capture-Luminescence Mus musculus
28 HMMR  
Affinity Capture-Western Homo sapiens
29 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 Aurkb  
Affinity Capture-Luminescence Mus musculus
31 TGFB1 7040
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 CLU 1191
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
33 Cdk17  
Affinity Capture-Luminescence Mus musculus
34 MYT1L  
Reconstituted Complex Homo sapiens
35 Arl4d  
Affinity Capture-Luminescence Mus musculus
36 Rhoj  
Affinity Capture-Luminescence Mus musculus
37 Rab34  
Affinity Capture-Luminescence Mus musculus
38 Rhoh 74734
Affinity Capture-Luminescence Mus musculus
39 CLEC2B  
Affinity Capture-MS Homo sapiens
40 MAPK14 1432
Affinity Capture-Western Homo sapiens
41 PSEN1 5663
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
42 CD3E 916
Affinity Capture-MS Homo sapiens
43 Chn1  
Affinity Capture-Luminescence Mus musculus
44 Csnk2a2 13000
Affinity Capture-Luminescence Mus musculus
45 ACVR2B  
Affinity Capture-MS Homo sapiens
46 Git2  
Affinity Capture-Luminescence Mus musculus
47 USP33  
Affinity Capture-MS Homo sapiens
48 Chn2  
Affinity Capture-Luminescence Mus musculus
49 USP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
50 SNX27 81609
Affinity Capture-MS Homo sapiens
51 TPM1 7168
Affinity Capture-Western Homo sapiens
52 NEDD4 4734
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 Usp45  
Affinity Capture-Luminescence Mus musculus
54 APPL1 26060
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
55 Itk  
Affinity Capture-Luminescence Mus musculus
56 Wwp2  
Affinity Capture-Luminescence Mus musculus
57 PAK1 5058
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
58 Katnb1  
Affinity Capture-Luminescence Mus musculus
59 Fkbp1b  
Affinity Capture-Luminescence Mus musculus
60 TOLLIP 54472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 Rtkn  
Affinity Capture-Luminescence Mus musculus
62 Arhgef6  
Affinity Capture-Luminescence Mus musculus
63 Fbxo24  
Affinity Capture-Luminescence Mus musculus
64 Atg16l1  
Affinity Capture-Luminescence Mus musculus
65 Arhgap31  
Affinity Capture-Luminescence Mus musculus
66 Usp21  
Affinity Capture-Luminescence Mus musculus
67 Nkiras1  
Affinity Capture-Luminescence Mus musculus
68 Ppp6c 67857
Affinity Capture-Luminescence Mus musculus
69 PSMD14 10213
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 PPP1R16B  
Affinity Capture-Western Homo sapiens
71 Efna1  
Affinity Capture-Luminescence Mus musculus
72 BAMBI  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 Wsb1  
Affinity Capture-Luminescence Mus musculus
74 Fancl  
Affinity Capture-Luminescence Mus musculus
75 Tssk3  
Affinity Capture-Luminescence Mus musculus
76 Wdr61  
Affinity Capture-Luminescence Mus musculus
77 Map2k3  
Affinity Capture-Luminescence Mus musculus
78 Rhoa 11848
Affinity Capture-Luminescence Mus musculus
79 SMAD3 4088
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 TAB2  
Affinity Capture-Luminescence Homo sapiens
81 Nup37  
Affinity Capture-Luminescence Mus musculus
82 Fbxw5  
Affinity Capture-Luminescence Mus musculus
83 HLA-G 3135
Affinity Capture-MS Homo sapiens
84 Ocln  
Affinity Capture-Luminescence Mus musculus
85 SMAD2 4087
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 GML  
Affinity Capture-MS Homo sapiens
87 Bcr  
Affinity Capture-Luminescence Mus musculus
88 ARHGEF6 9459
Affinity Capture-Western Homo sapiens
89 PIK3R1 5295
Affinity Capture-Western Homo sapiens
90 Preb  
Affinity Capture-Luminescence Mus musculus
91 Myo3a  
Affinity Capture-Luminescence Mus musculus
92 ITCH 83737
Affinity Capture-Western Homo sapiens
93 Ikbkb 16150
Affinity Capture-Luminescence Mus musculus
94 Eif2ak1  
Affinity Capture-Luminescence Mus musculus
95 Skap2  
Affinity Capture-Luminescence Mus musculus
96 Pard6a  
Affinity Capture-Luminescence Mus musculus
97 Btbd2  
Affinity Capture-Luminescence Mus musculus
98 Plek  
Affinity Capture-Luminescence Mus musculus
99 Gnb3  
Affinity Capture-Luminescence Mus musculus
100 Smad7  
Affinity Capture-Western Mus musculus
Affinity Capture-Luminescence Mus musculus
101 ZAK 51776
Affinity Capture-Western Homo sapiens
102 USP4 7375
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
103 Rhpn2  
Affinity Capture-Luminescence Mus musculus
104 ANK1 286
Affinity Capture-Western Homo sapiens
105 CANX 821
Affinity Capture-MS Homo sapiens
106 ICAM2 3384
Affinity Capture-MS Homo sapiens
107 Gnb2 14693
Affinity Capture-Luminescence Mus musculus
108 Ube2e3  
Affinity Capture-Luminescence Mus musculus
109 USP15 9958
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 ACVRL1 94
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 Fbxl12  
Affinity Capture-Luminescence Mus musculus
112 TNFSF8  
Affinity Capture-MS Homo sapiens
113 KCNK18  
Affinity Capture-Western Homo sapiens
114 Bmpr2 12168
Affinity Capture-Luminescence Mus musculus
115 Samd8  
Affinity Capture-Luminescence Mus musculus
116 Rab6b  
Affinity Capture-Luminescence Mus musculus
117 Rab3b  
Affinity Capture-Luminescence Mus musculus
118 GOLT1B 51026
Affinity Capture-MS Homo sapiens
119 TRAF6 7189
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
120 Noxo1  
Affinity Capture-Luminescence Mus musculus
121 RASSF1  
Affinity Capture-Western Homo sapiens
122 CLEC4A  
Affinity Capture-MS Homo sapiens
123 KLRD1  
Affinity Capture-MS Homo sapiens
124 FNTA 2339
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
125 Prpf4  
Affinity Capture-Luminescence Mus musculus
126 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 Rnf138  
Affinity Capture-Luminescence Mus musculus
128 SPTBN1 6711
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
129 CDC42 998
Affinity Capture-Western Homo sapiens
130 STRAP 11171
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
131 Rab38  
Affinity Capture-Luminescence Mus musculus
132 RANBP9 10048
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
133 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
134 Stx8 55943
Affinity Capture-Luminescence Mus musculus
135 Ilkap  
Affinity Capture-Luminescence Mus musculus
136 BMPR2 659
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
138 Rap2a  
Affinity Capture-Luminescence Mus musculus
139 Cdc42ep4  
Affinity Capture-Luminescence Mus musculus
140 Ttc1  
Affinity Capture-Luminescence Mus musculus
141 GPR45  
Affinity Capture-MS Homo sapiens
142 PSCA 8000
Affinity Capture-MS Homo sapiens
143 Rhod  
Affinity Capture-Luminescence Mus musculus
144 Naa20  
Affinity Capture-Luminescence Mus musculus
145 HSPA4 3308
Affinity Capture-Western Homo sapiens
146 Eif2ak4  
Affinity Capture-Luminescence Mus musculus
147 ENTPD2 954
Affinity Capture-MS Homo sapiens
148 SMAD6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 Dapk2  
Affinity Capture-Luminescence Mus musculus
150 Rab33b  
Affinity Capture-Luminescence Mus musculus
151 Nek6  
Affinity Capture-Luminescence Mus musculus
152 Cdkl1  
Affinity Capture-Luminescence Mus musculus
153 Plekhb1  
Affinity Capture-Luminescence Mus musculus
154 CD44 960
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
155 Gna13 14674
Affinity Capture-Luminescence Mus musculus
156 Nuak2  
Affinity Capture-Luminescence Mus musculus
157 Rgs19  
Affinity Capture-Luminescence Mus musculus
158 Chuk  
Affinity Capture-Luminescence Mus musculus
159 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
160 Ubd 24108
Affinity Capture-Luminescence Mus musculus
161 Stat1 20846
Affinity Capture-Luminescence Mus musculus
162 OTUB1 55611
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
163 NRP1 8829
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 FASN 2194
Negative Genetic Homo sapiens
165 DAB2 1601
Affinity Capture-Western Homo sapiens
166 Cdk14  
Affinity Capture-Luminescence Mus musculus
167 SKIL  
Affinity Capture-Western Homo sapiens
168 TGFBR2 7048
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
169 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
170 Arhgap15  
Affinity Capture-Luminescence Mus musculus
171 Rab13 68328
Affinity Capture-Luminescence Mus musculus
172 Fbxo3  
Affinity Capture-Luminescence Mus musculus
173 Uhmk1  
Affinity Capture-Luminescence Mus musculus
174 NLGN3  
Affinity Capture-MS Homo sapiens
175 ENG 2022
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
176 TMEM30B 161291
Affinity Capture-MS Homo sapiens
177 Dusp10  
Affinity Capture-Luminescence Mus musculus
178 SMURF1 57154
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
179 OXSR1 9943
Affinity Capture-Western Homo sapiens
180 SMAD4  
Affinity Capture-Luminescence Homo sapiens
Co-fractionation Homo sapiens
181 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
182 Irf7  
Affinity Capture-Luminescence Mus musculus
183 Nek8  
Affinity Capture-Luminescence Mus musculus
184 Fbxo34  
Affinity Capture-Luminescence Mus musculus
185 Mknk2  
Affinity Capture-Luminescence Mus musculus
186 HSP90AA1 3320
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
187 FKBP1A 2280
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
188 Cdc20  
Affinity Capture-Luminescence Mus musculus
189 SFTPC  
Affinity Capture-MS Homo sapiens
190 EVA1C  
Affinity Capture-MS Homo sapiens
191 Klhl1  
Affinity Capture-Luminescence Mus musculus
192 PLD3 23646
Affinity Capture-MS Homo sapiens
193 TSC22D1 8848
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
194 Rasd2  
Affinity Capture-Luminescence Mus musculus
195 Rnf130 59044
Affinity Capture-Luminescence Mus musculus
196 Cdk6 12571
Affinity Capture-Luminescence Mus musculus
197 EPHA2 1969
Affinity Capture-MS Homo sapiens
198 Cul5 75717
Affinity Capture-Luminescence Mus musculus
199 PIK3R2 5296
Affinity Capture-Western Homo sapiens
200 ACVR1C  
Affinity Capture-MS Homo sapiens
201 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
202 Fkbp1a 14225
Affinity Capture-Luminescence Mus musculus
203 SMURF2 64750
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
204 Dusp6  
Affinity Capture-Luminescence Mus musculus
205 PPP2R2A 5520
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
206 CAV1 857
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
207 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
208 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
209 HLA-C 3107
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TGFBR1 is involved
PathwayEvidenceSource
Deubiquitination IEA Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of TGF-beta receptor signaling IEA Reactome
Downregulation of TGF-beta receptor signaling TAS Reactome
Loss of Function of SMAD2/3 in Cancer TAS Reactome
Loss of Function of TGFBR1 in Cancer TAS Reactome
Loss of Function of TGFBR2 in Cancer TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of proteins TAS Reactome
Post-translational protein modification IEA Reactome
Post-translational protein modification TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGF-beta Receptor Complex in Cancer TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFB family members IEA Reactome
Signaling by TGFBR3 TAS Reactome
SMAD2/3 Phosphorylation Motif Mutants in Cancer TAS Reactome
TGF-beta receptor signaling activates SMADs TAS Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TAS Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IEA Reactome
TGFBR1 KD Mutants in Cancer TAS Reactome
TGFBR1 LBD Mutants in Cancer TAS Reactome
TGFBR2 Kinase Domain Mutants in Cancer TAS Reactome
TGFBR3 regulates TGF-beta signaling TAS Reactome
Ub-specific processing proteases TAS Reactome
UCH proteinases IEA Reactome





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