Gene description for SMAD2
Gene name	SMAD family member 2
Gene symbol	SMAD2
Other names/aliases	JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2
Species	Homo sapiens
Database cross references - SMAD2
ExoCarta	ExoCarta_4087
Entrez Gene	4087
HGNC	6768
MIM	601366
UniProt	Q15796
SMAD2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for SMAD2

Molecular Function     I-SMAD binding GO:0070411 IPI     double-stranded DNA binding GO:0003690 ISS     co-SMAD binding GO:0070410 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     protein binding GO:0005515 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA     enhancer binding GO:0035326 IC     type I transforming growth factor beta receptor binding GO:0034713 IPI     phosphatase binding GO:0019902 IPI     metal ion binding GO:0046872 IEA     transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 IDA     transforming growth factor beta receptor binding GO:0005160 IPI     chromatin binding GO:0003682 IEA     SMAD binding GO:0046332 IPI     transcription factor binding GO:0008134 IPI     activating transcription factor binding GO:0033613 IPI     R-SMAD binding GO:0070412 IPI     ubiquitin protein ligase binding GO:0031625 IPI     DNA binding GO:0003677 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 IDA Biological Process     SMAD protein signal transduction GO:0060395 IEA     pancreas development GO:0031016 IEA     zygotic specification of dorsal/ventral axis GO:0007352 IMP     positive regulation of transcription, DNA-templated GO:0045893 ISS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     response to cholesterol GO:0070723 IDA     primary miRNA processing GO:0031053 TAS     gene expression GO:0010467 TAS     nodal signaling pathway GO:0038092 IMP     common-partner SMAD protein phosphorylation GO:0007182 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     embryonic foregut morphogenesis GO:0048617 IEA     negative regulation of transcription, DNA-templated GO:0045892 IMP     activin receptor signaling pathway GO:0032924 IMP     negative regulation of cell proliferation GO:0008285 IEA     positive regulation of BMP signaling pathway GO:0030513 IMP     regulation of binding GO:0051098 ISS     SMAD protein complex assembly GO:0007183 IDA     signal transduction involved in regulation of gene expression GO:0023019 IEA     post-embryonic development GO:0009791 IEA     lung development GO:0030324 IEA     somatic stem cell maintenance GO:0035019 TAS     regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IMP     ureteric bud development GO:0001657 IEA     endoderm formation GO:0001706 IEA     embryonic cranial skeleton morphogenesis GO:0048701 IEA     organ growth GO:0035265 IEA     response to glucose GO:0009749 IEA     in utero embryonic development GO:0001701 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     intracellular signal transduction GO:0035556 ISS     mesoderm formation GO:0001707 ISS     anterior/posterior pattern specification GO:0009952 ISS     cell fate commitment GO:0045165 ISS     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     positive regulation of epithelial to mesenchymal transition GO:0010718 ISS     palate development GO:0060021 ISS     gastrulation GO:0007369 TAS     pericardium development GO:0060039 IEA     positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry GO:1900224 IMP     paraxial mesoderm morphogenesis GO:0048340 ISS     insulin secretion GO:0030073 IEA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS     transcription, DNA-templated GO:0006351 TAS Subcellular Localization     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     nuclear chromatin GO:0000790 IDA     cytosol GO:0005829 TAS     transcription factor complex GO:0005667 IDA     SMAD2-SMAD3 protein complex GO:0071144 IDA     SMAD protein complex GO:0071141 IDA     activin responsive factor complex GO:0032444 IDA