Gene description for PPARG
Gene name	peroxisome proliferator-activated receptor gamma
Gene symbol	PPARG
Other names/aliases	CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma
Species	Homo sapiens
Database cross references - PPARG
ExoCarta	ExoCarta_5468
Vesiclepedia	VP_5468
Entrez Gene	5468
HGNC	9236
MIM	601487
UniProt	P37231
PPARG identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Plasma	19028452

Gene ontology annotations for PPARG

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     transcription cis-regulatory region binding GO:0000976 ISS     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     transcription coregulator binding GO:0001221 IPI     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     nucleic acid binding GO:0003676 EXP     DNA binding GO:0003677 IDA     DNA binding GO:0003677 ISS     chromatin binding GO:0003682 ISS     double-stranded DNA binding GO:0003690 IMP     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 ISS     nuclear receptor activity GO:0004879 IBA     nuclear receptor activity GO:0004879 IDA     prostaglandin receptor activity GO:0004955 TAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IDA     enzyme binding GO:0019899 IPI     peptide binding GO:0042277 IDA     identical protein binding GO:0042802 IPI     sequence-specific DNA binding GO:0043565 IDA     nuclear retinoid X receptor binding GO:0046965 IDA     nuclear retinoid X receptor binding GO:0046965 IPI     arachidonate binding GO:0050544 ISS     DNA binding domain binding GO:0050692 IDA     LBD domain binding GO:0050693 IDA     WW domain binding GO:0050699 IMP     alpha-actinin binding GO:0051393 IPI     R-SMAD binding GO:0070412 IPI     E-box binding GO:0070888 ISS     STAT family protein binding GO:0097677 IPI     DNA-binding transcription factor binding GO:0140297 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IBA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     placenta development GO:0001890 ISS     regulation of transcription by RNA polymerase II GO:0006357 ISS     lipid metabolic process GO:0006629 TAS     fatty acid metabolic process GO:0006631 IBA     signal transduction GO:0007165 IDA     G protein-coupled receptor signaling pathway GO:0007186 IEA     response to nutrient GO:0007584 TAS     regulation of blood pressure GO:0008217 IMP     hormone-mediated signaling pathway GO:0009755 IBA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IGI     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISS     negative regulation of gene expression GO:0010629 IDA     negative regulation of gene expression GO:0010629 IGI     negative regulation of gene expression GO:0010629 ISS     negative regulation of gene expression GO:0010629 ISS     negative regulation of macrophage derived foam cell differentiation GO:0010745 IC     negative regulation of macrophage derived foam cell differentiation GO:0010745 IDA     positive regulation of cholesterol efflux GO:0010875 IDA     negative regulation of cholesterol storage GO:0010887 IBA     negative regulation of cholesterol storage GO:0010887 IDA     negative regulation of lipid storage GO:0010888 ISS     negative regulation of sequestering of triglyceride GO:0010891 IDA     long-chain fatty acid transport GO:0015909 ISS     negative regulation of angiogenesis GO:0016525 IDA     cell differentiation GO:0030154 IBA     monocyte differentiation GO:0030224 IDA     BMP signaling pathway GO:0030509 IGI     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IGI     negative regulation of BMP signaling pathway GO:0030514 IMP     epithelial cell differentiation GO:0030855 ISS     positive regulation of cholesterol transport GO:0032376 IDA     cellular response to insulin stimulus GO:0032869 IMP     cellular response to insulin stimulus GO:0032869 ISS     response to lipid GO:0033993 ISS     peroxisome proliferator activated receptor signaling pathway GO:0035357 IDA     peroxisome proliferator activated receptor signaling pathway GO:0035357 IGI     peroxisome proliferator activated receptor signaling pathway GO:0035357 IMP     peroxisome proliferator activated receptor signaling pathway GO:0035357 NAS     glucose homeostasis GO:0042593 IMP     regulation of circadian rhythm GO:0042752 ISS     mRNA transcription by RNA polymerase II GO:0042789 IDA     mRNA transcription by RNA polymerase II GO:0042789 ISS     lipoprotein transport GO:0042953 IDA     negative regulation of MAPK cascade GO:0043409 IDA     negative regulation of blood vessel endothelial cell migration GO:0043537 IDA     innate immune response GO:0045087 TAS     cell fate commitment GO:0045165 ISS     positive regulation of fat cell differentiation GO:0045600 ISS     negative regulation of osteoblast differentiation GO:0045668 IMP     negative regulation of DNA-templated transcription GO:0045892 ISS     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of DNA-templated transcription GO:0045893 ISS     positive regulation of fatty acid metabolic process GO:0045923 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     retinoic acid receptor signaling pathway GO:0048384 IDA     cell maturation GO:0048469 IDA     rhythmic process GO:0048511 IEA     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     negative regulation of smooth muscle cell proliferation GO:0048662 IGI     negative regulation of smooth muscle cell proliferation GO:0048662 IMP     negative regulation of smooth muscle cell proliferation GO:0048662 ISS     negative regulation of inflammatory response GO:0050728 IBA     white fat cell differentiation GO:0050872 TAS     lipid homeostasis GO:0055088 TAS     negative regulation of type II interferon-mediated signaling pathway GO:0060336 IMP     negative regulation of SMAD protein signal transduction GO:0060392 IGI     positive regulation of adiponectin secretion GO:0070165 ISS     cellular response to low-density lipoprotein particle stimulus GO:0071404 IDA     cellular response to hypoxia GO:0071456 ISS     negative regulation of mitochondrial fission GO:0090258 IMP     regulation of cellular response to insulin stimulus GO:1900076 NAS     negative regulation of extracellular matrix assembly GO:1901202 IDA     negative regulation of miRNA transcription GO:1902894 IDA     negative regulation of miRNA transcription GO:1902894 IMP     positive regulation of miRNA transcription GO:1902895 IDA     negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISS     negative regulation of cellular response to transforming growth factor beta stimulus GO:1903845 IGI     positive regulation of adipose tissue development GO:1904179 NAS     negative regulation of connective tissue replacement involved in inflammatory response wound healing GO:1904597 ISS     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IDA     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP     negative regulation of receptor signaling pathway via STAT GO:1904893 IDA     positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 IMP     negative regulation of vascular endothelial cell proliferation GO:1905563 IMP     positive regulation of low-density lipoprotein receptor activity GO:1905599 IDA     negative regulation of signaling receptor activity GO:2000272 IDA     positive regulation of apoptotic signaling pathway GO:2001235 IDA Subcellular Localization     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 ISS     intracellular membrane-bounded organelle GO:0043231 IDA     receptor complex GO:0043235 IDA     RNA polymerase II transcription regulator complex GO:0090575 EXP     RNA polymerase II transcription regulator complex GO:0090575 IDA