Gene description for PPARG
Gene name	peroxisome proliferator-activated receptor gamma
Gene symbol	PPARG
Other names/aliases	CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma
Species	Homo sapiens
Database cross references - PPARG
ExoCarta	ExoCarta_5468
Entrez Gene	5468
HGNC	9236
MIM	601487
UniProt	P37231
PPARG identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Plasma	19028452

Gene ontology annotations for PPARG

Molecular Function     estrogen receptor binding GO:0030331 IEA     protein phosphatase binding GO:0019903 IEA     drug binding GO:0008144 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 ISS     transcription regulatory region DNA binding GO:0044212 ISS     DNA binding GO:0003677 ISS     ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 IDA     protein binding GO:0005515 IPI     retinoid X receptor binding GO:0046965 IDA     prostaglandin receptor activity GO:0004955 TAS     arachidonic acid binding GO:0050544 ISS     enzyme binding GO:0019899 IPI     steroid hormone receptor activity GO:0003707 IEA     core promoter sequence-specific DNA binding GO:0001046 ISS     sequence-specific DNA binding GO:0043565 IDA     activating transcription factor binding GO:0033613 IDA     ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IDA     RNA polymerase II regulatory region DNA binding GO:0001012 IEA     RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IEA     chromatin binding GO:0003682 ISS     zinc ion binding GO:0008270 IEA     alpha-actinin binding GO:0051393 IPI Biological Process     response to starvation GO:0042594 IEA     negative regulation of collagen biosynthetic process GO:0032966 IEA     innate immune response GO:0045087 TAS     negative regulation of acute inflammatory response GO:0002674 IEA     negative regulation of cell growth GO:0030308 IEA     heart development GO:0007507 IEA     long-chain fatty acid transport GO:0015909 ISS     response to lipid GO:0033993 ISS     glucose homeostasis GO:0042593 IMP     response to metformin GO:1901558 IEA     response to low-density lipoprotein particle GO:0055098 IDA     epithelial cell differentiation GO:0030855 ISS     peroxisome proliferator activated receptor signaling pathway GO:0035357 IMP     cellular response to retinoic acid GO:0071300 IEA     negative regulation of telomerase activity GO:0051974 IEA     regulation of cholesterol transporter activity GO:0060694 IC     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     response to diuretic GO:0036270 IEA     rhythmic process GO:0048511 IEA     negative regulation of cholesterol storage GO:0010887 IDA     positive regulation of phagocytosis, engulfment GO:0060100 IEA     monocyte differentiation GO:0030224 IDA     response to cold GO:0009409 IEA     response to retinoic acid GO:0032526 IDA     cell maturation GO:0048469 IDA     negative regulation of transcription, DNA-templated GO:0045892 ISS     positive regulation of transcription, DNA-templated GO:0045893 ISS     fatty acid oxidation GO:0019395 IEA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     positive regulation of fatty acid oxidation GO:0046321 IEA     negative regulation of interferon-gamma-mediated signaling pathway GO:0060336 IMP     response to immobilization stress GO:0035902 IEA     white fat cell differentiation GO:0050872 TAS     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     cellular response to vitamin E GO:0071306 IEA     organ regeneration GO:0031100 IEA     response to caffeine GO:0031000 IEA     gene expression GO:0010467 TAS     regulation of blood pressure GO:0008217 IMP     cellular response to lithium ion GO:0071285 IEA     negative regulation of sequestering of triglyceride GO:0010891 IDA     positive regulation of fat cell differentiation GO:0045600 ISS     lipoprotein transport GO:0042953 IDA     placenta development GO:0001890 ISS     lipid metabolic process GO:0006629 TAS     regulation of circadian rhythm GO:0042752 ISS     response to mechanical stimulus GO:0009612 IEA     steroid hormone mediated signaling pathway GO:0043401 IEA     response to nutrient GO:0007584 TAS     cellular response to hyperoxia GO:0071455 IEA     cell fate commitment GO:0045165 ISS     negative regulation of pancreatic stellate cell proliferation GO:2000230 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     negative regulation of receptor biosynthetic process GO:0010871 IDA     response to vitamin A GO:0033189 IEA     brown fat cell differentiation GO:0050873 IEA     lipid homeostasis GO:0055088 TAS     G-protein coupled receptor signaling pathway GO:0007186 TAS     cellular response to insulin stimulus GO:0032869 IMP     negative regulation of macrophage derived foam cell differentiation GO:0010745 IDA     cellular response to prostaglandin E stimulus GO:0071380 IEA     response to estrogen GO:0043627 IEA     low-density lipoprotein particle receptor biosynthetic process GO:0045713 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     signal transduction GO:0007165 IDA     regulation of transcription involved in cell fate commitment GO:0060850 ISS Subcellular Localization     RNA polymerase II transcription factor complex GO:0090575 IDA     cytosol GO:0005829 ISS     perinuclear region of cytoplasm GO:0048471 IEA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA