Gene description for FGFR2
Gene name	fibroblast growth factor receptor 2
Gene symbol	FGFR2
Other names/aliases	BBDS BEK BFR-1 CD332 CEK3 CFD1 ECT1 JWS K-SAM KGFR TK14 TK25
Species	Homo sapiens
Database cross references - FGFR2
ExoCarta	ExoCarta_2263
Vesiclepedia	VP_2263
Entrez Gene	2263
HGNC	3689
MIM	176943
UniProt	P21802
FGFR2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for FGFR2

Molecular Function     protein tyrosine kinase activity GO:0004713 NAS     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IBA     fibroblast growth factor receptor activity GO:0005007 IDA     fibroblast growth factor receptor activity GO:0005007 IGI     fibroblast growth factor receptor activity GO:0005007 NAS     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     heparin binding GO:0008201 IEA     boss receptor activity GO:0008288 IEA     fibroblast growth factor binding GO:0017134 IBA     fibroblast growth factor binding GO:0017134 IDA     fibroblast growth factor binding GO:0017134 IPI     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IPI     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     angiogenesis GO:0001525 ISS     ureteric bud development GO:0001657 ISS     in utero embryonic development GO:0001701 ISS     epithelial to mesenchymal transition GO:0001837 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 ISS     outflow tract septum morphogenesis GO:0003148 ISS     membranous septum morphogenesis GO:0003149 ISS     endochondral bone growth GO:0003416 IEA     chromatin remodeling GO:0006338 IEA     apoptotic process GO:0006915 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     cell-cell signaling GO:0007267 ISS     multicellular organism development GO:0007275 IBA     axonogenesis GO:0007409 ISS     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 IMP     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IDA     fibroblast growth factor receptor signaling pathway GO:0008543 IGI     fibroblast growth factor receptor signaling pathway GO:0008543 IPI     regulation of smoothened signaling pathway GO:0008589 ISS     post-embryonic development GO:0009791 ISS     embryonic pattern specification GO:0009880 ISS     animal organ morphogenesis GO:0009887 ISS     positive regulation of phospholipase activity GO:0010518 IMP     negative regulation of keratinocyte proliferation GO:0010839 IMP     morphogenesis of embryonic epithelium GO:0016331 ISS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     orbitofrontal cortex development GO:0021769 ISS     ventricular zone neuroblast division GO:0021847 ISS     pyramidal neuron development GO:0021860 ISS     gland morphogenesis GO:0022612 ISS     positive regulation of Wnt signaling pathway GO:0030177 ISS     bone mineralization GO:0030282 ISS     lung development GO:0030324 ISS     epithelial cell differentiation GO:0030855 ISS     midbrain development GO:0030901 ISS     otic vesicle formation GO:0030916 ISS     hair follicle morphogenesis GO:0031069 ISS     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     response to lipopolysaccharide GO:0032496 IEA     lacrimal gland development GO:0032808 ISS     regulation of osteoblast proliferation GO:0033688 TAS     organ growth GO:0035265 ISS     fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell GO:0035602 ISS     fibroblast growth factor receptor signaling pathway involved in hemopoiesis GO:0035603 ISS     fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow GO:0035604 ISS     fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 ISS     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     inner ear morphogenesis GO:0042472 ISS     odontogenesis GO:0042476 ISS     positive regulation of MAPK cascade GO:0043410 IMP     cell fate commitment GO:0045165 ISS     response to ethanol GO:0045471 IEA     regulation of osteoblast differentiation GO:0045667 TAS     positive regulation of cell cycle GO:0045787 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     protein autophosphorylation GO:0046777 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     lung alveolus development GO:0048286 ISS     mesodermal cell differentiation GO:0048333 IEA     embryonic digestive tract morphogenesis GO:0048557 ISS     embryonic organ morphogenesis GO:0048562 ISS     digestive tract development GO:0048565 ISS     embryonic organ development GO:0048568 ISS     reproductive structure development GO:0048608 ISS     embryonic cranial skeleton morphogenesis GO:0048701 IMP     skeletal system morphogenesis GO:0048705 TAS     epidermis morphogenesis GO:0048730 ISS     branching morphogenesis of a nerve GO:0048755 ISS     mesenchymal cell differentiation GO:0048762 ISS     positive regulation of epithelial cell proliferation GO:0050679 ISS     regulation of smooth muscle cell differentiation GO:0051150 ISS     positive regulation of cell division GO:0051781 ISS     ventricular cardiac muscle tissue morphogenesis GO:0055010 ISS     positive regulation of cardiac muscle cell proliferation GO:0060045 ISS     limb bud formation GO:0060174 ISS     bone development GO:0060348 ISS     bone morphogenesis GO:0060349 ISS     branching involved in prostate gland morphogenesis GO:0060442 ISS     branching involved in salivary gland morphogenesis GO:0060445 ISS     bud elongation involved in lung branching GO:0060449 ISS     lung lobe morphogenesis GO:0060463 ISS     lung-associated mesenchyme development GO:0060484 ISS     positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 ISS     prostate gland morphogenesis GO:0060512 ISS     prostate epithelial cord elongation GO:0060523 ISS     prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 ISS     squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0060529 ISS     fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 ISS     lateral sprouting from an epithelium GO:0060601 ISS     mammary gland bud formation GO:0060615 ISS     epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 ISS     branch elongation involved in salivary gland morphogenesis GO:0060667 ISS     branching involved in labyrinthine layer morphogenesis GO:0060670 ISS     regulation of morphogenesis of a branching structure GO:0060688 ISS     mesenchymal cell differentiation involved in lung development GO:0060915 ISS     mesenchymal cell proliferation involved in lung development GO:0060916 ISS     regulation of ERK1 and ERK2 cascade GO:0070372 ISS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     cellular response to retinoic acid GO:0071300 IEA     cellular response to hypoxia GO:0071456 IEA     cellular response to transforming growth factor beta stimulus GO:0071560 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 ISS     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA Subcellular Localization     extracellular region GO:0005576 IEA     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     Golgi apparatus GO:0005794 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell cortex GO:0005938 IDA     cell surface GO:0009986 IDA     membrane GO:0016020 NAS     cytoplasmic vesicle GO:0031410 IEA     receptor complex GO:0043235 IBA     excitatory synapse GO:0060076 ISS     collagen-containing extracellular matrix GO:0062023 IDA