Gene description for HDAC5
Gene name	histone deacetylase 5
Gene symbol	HDAC5
Other names/aliases	HD5 NY-CO-9
Species	Homo sapiens
Database cross references - HDAC5
ExoCarta	ExoCarta_10014
Vesiclepedia	VP_10014
Entrez Gene	10014
HGNC	14068
MIM	605315
UniProt	Q9UQL6
HDAC5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for HDAC5

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     transcription corepressor binding GO:0001222 IPI     chromatin binding GO:0003682 IEA     histone deacetylase activity GO:0004407 IBA     histone deacetylase activity GO:0004407 IDA     protein kinase C binding GO:0005080 IPI     protein binding GO:0005515 IPI     histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA     histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA     protein lysine deacetylase activity GO:0033558 IMP     histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA     identical protein binding GO:0042802 IPI     histone deacetylase binding GO:0042826 IPI     metal ion binding GO:0046872 IEA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     DNA-binding transcription factor binding GO:0140297 IPI     histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA     histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA     histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA     histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     inflammatory response GO:0006954 TAS     response to xenobiotic stimulus GO:0009410 IEA     regulation of myotube differentiation GO:0010830 ISS     negative regulation of myotube differentiation GO:0010832 IMP     response to activity GO:0014823 IEA     neuron differentiation GO:0030182 IEA     B cell differentiation GO:0030183 TAS     cellular response to insulin stimulus GO:0032869 NAS     epigenetic regulation of gene expression GO:0040029 IBA     B cell activation GO:0042113 TAS     response to cocaine GO:0042220 IEA     regulation of protein binding GO:0043393 IMP     negative regulation of gene expression, epigenetic GO:0045814 NAS     negative regulation of DNA-templated transcription GO:0045892 TAS     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of DNA-binding transcription factor activity GO:0051091 IMP     cellular response to lipopolysaccharide GO:0071222 IEA     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IMP Subcellular Localization     histone deacetylase complex GO:0000118 IBA     histone deacetylase complex GO:0000118 TAS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IDA     nuclear speck GO:0016607 IDA