Gene description for HDAC5
Gene name	histone deacetylase 5
Gene symbol	HDAC5
Other names/aliases	HD5 NY-CO-9
Species	Homo sapiens
Database cross references - HDAC5
ExoCarta	ExoCarta_10014
Entrez Gene	10014
HGNC	14068
MIM	605315
UniProt	Q9UQL6
HDAC5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for HDAC5

Molecular Function     transcription corepressor activity GO:0003714 IEA     transcription regulatory region DNA binding GO:0044212 IDA     metal ion binding GO:0046872 IEA     NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA     transcription factor binding GO:0008134 IPI     NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA     NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA     repressing transcription factor binding GO:0070491 IPI     protein binding GO:0005515 IPI     RNA polymerase III transcription factor binding GO:0001025 IPI     NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA     protein kinase C binding GO:0005080 IPI     protein deacetylase activity GO:0033558 IMP     core promoter binding GO:0001047 IDA     histone deacetylase binding GO:0042826 IPI     histone deacetylase activity GO:0004407 IDA Biological Process     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IMP     response to drug GO:0042493 IEA     regulation of skeletal muscle fiber development GO:0048742 IEA     Notch signaling pathway GO:0007219 TAS     cellular response to insulin stimulus GO:0032869 NAS     histone H3-K9 deacetylation GO:1990619 IEA     chromatin modification GO:0016568 TAS     negative regulation of myotube differentiation GO:0010832 IMP     inflammatory response GO:0006954 TAS     multicellular organismal response to stress GO:0033555 IEA     histone H4 deacetylation GO:0070933 IEA     transcription, DNA-templated GO:0006351 IEA     B cell differentiation GO:0030183 TAS     chromatin remodeling GO:0006338 TAS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP     chromatin silencing GO:0006342 TAS     heart development GO:0007507 IEA     regulation of gene expression, epigenetic GO:0040029 IMP     response to cocaine GO:0042220 IEA     negative regulation of osteoblast differentiation GO:0045668 IEA     regulation of myotube differentiation GO:0010830 ISS     histone deacetylation GO:0016575 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     regulation of histone H3-K9 acetylation GO:2000615 IMP     regulation of protein binding GO:0043393 IMP     histone H3-K9 modification GO:0061647 IEA     protein deacetylation GO:0006476 IMP     negative regulation of transcription, DNA-templated GO:0045892 TAS     chromatin organization GO:0006325 TAS     osteoblast development GO:0002076 IEA     B cell activation GO:0042113 TAS Subcellular Localization     histone deacetylase complex GO:0000118 TAS     cytosol GO:0005829 IEA     nucleus GO:0005634 IDA     Golgi apparatus GO:0005794 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     nuclear body GO:0016604 IEA