Gene description for STAT5B
Gene name signal transducer and activator of transcription 5B
Gene symbol STAT5B
Other names/aliases STAT5
Species Homo sapiens
 Database cross references - STAT5B
ExoCarta ExoCarta_6777
Entrez Gene 6777
HGNC 11367
MIM 604260
UniProt P51692  
 STAT5B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for STAT5B
Molecular Function
    glucocorticoid receptor binding GO:0035259 IPI
    protein binding GO:0005515 IPI
    signal transducer activity GO:0004871 IEA
    protein dimerization activity GO:0046983 ISS
    protein phosphatase binding GO:0019903 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    chromatin binding GO:0003682 ISS
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    double-stranded DNA binding GO:0003690 IEA
Biological Process
    cellular response to hormone stimulus GO:0032870 IDA
    T cell homeostasis GO:0043029 IEA
    prolactin signaling pathway GO:0038161 ISS
    positive regulation of cellular component movement GO:0051272 IEA
    response to interleukin-2 GO:0070669 IEA
    positive regulation of gamma-delta T cell differentiation GO:0045588 IEA
    fatty acid metabolic process GO:0006631 ISS
    positive regulation of B cell differentiation GO:0045579 IEA
    regulation of steroid metabolic process GO:0019218 IEA
    cellular response to epidermal growth factor stimulus GO:0071364 ISS
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    response to lipopolysaccharide GO:0032496 IEA
    oxaloacetate metabolic process GO:0006107 ISS
    Peyer's patch development GO:0048541 IEA
    succinate metabolic process GO:0006105 ISS
    2-oxoglutarate metabolic process GO:0006103 ISS
    positive regulation of interleukin-2 biosynthetic process GO:0045086 IEA
    development of secondary male sexual characteristics GO:0046544 IEA
    valine metabolic process GO:0006573 ISS
    taurine metabolic process GO:0019530 ISS
    isoleucine metabolic process GO:0006549 ISS
    JAK-STAT cascade GO:0007259 TAS
    creatinine metabolic process GO:0046449 ISS
    response to hypoxia GO:0001666 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    response to interleukin-4 GO:0070670 IEA
    positive regulation of activated T cell proliferation GO:0042104 IEA
    female pregnancy GO:0007565 IEA
    positive regulation of inflammatory response GO:0050729 IEA
    T cell differentiation in thymus GO:0033077 IEA
    lactation GO:0007595 IEA
    allantoin metabolic process GO:0000255 ISS
    response to interleukin-15 GO:0070672 IEA
    regulation of multicellular organism growth GO:0040014 ISS
    liver development GO:0001889 IEA
    acute-phase response GO:0006953 IEA
    positive regulation of natural killer cell proliferation GO:0032819 IEA
    development of secondary female sexual characteristics GO:0046543 IEA
    cellular response to growth factor stimulus GO:0071363 ISS
    negative regulation of erythrocyte differentiation GO:0045647 IEA
    positive regulation of natural killer cell differentiation GO:0032825 IEA
    response to estradiol GO:0032355 IDA
    positive regulation of multicellular organism growth GO:0040018 IEA
    response to ethanol GO:0045471 IEA
    JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    negative regulation of apoptotic process GO:0043066 IEA
    lipid storage GO:0019915 IEA
    citrate metabolic process GO:0006101 ISS
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    progesterone metabolic process GO:0042448 IEA
    positive regulation of mitotic cell cycle GO:0045931 IEA
    regulation of epithelial cell differentiation GO:0030856 IEA
    luteinization GO:0001553 IEA
    creatine metabolic process GO:0006600 ISS
    natural killer cell differentiation GO:0001779 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 ISS
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified STAT5B in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for STAT5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Invitro Homo sapiens
2 CD247 919
Invivo Homo sapiens
3 IL2RB  
Reconstituted Complex Homo sapiens
4 GHR  
Invivo Homo sapiens
Invitro Homo sapiens
5 JAK3 3718
Two-hybrid Homo sapiens
6 PTPN11 5781
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
8 NR3C1 2908
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 JAK2 3717
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 EGFR 1956
Invivo Homo sapiens
11 JAK1 3716
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 NMI  
Two-hybrid Homo sapiens
13 PTPN6 5777
Invivo Homo sapiens
14 NCOR2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
15 ELP2 55250
Reconstituted Complex Homo sapiens
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