Gene description for BAG1
Gene name BCL2-associated athanogene
Gene symbol BAG1
Other names/aliases BAG-1
HAP
RAP46
Species Homo sapiens
 Database cross references - BAG1
ExoCarta ExoCarta_573
Entrez Gene 573
HGNC 937
MIM 601497
UniProt Q99933  
 BAG1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for BAG1
Molecular Function
    protein binding GO:0005515 IPI
    chaperone binding GO:0051087 IEA
    receptor signaling protein activity GO:0005057 TAS
Biological Process
    cellular response to heat GO:0034605 TAS
    intracellular signal transduction GO:0035556 TAS
    apoptotic process GO:0006915 IEA
    regulation of cellular response to heat GO:1900034 TAS
    chaperone cofactor-dependent protein refolding GO:0070389 IDA
    cell surface receptor signaling pathway GO:0007166 TAS
    negative regulation of apoptotic process GO:0043066 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified BAG1 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BAG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 RB1 5925
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 ST13 6767
Affinity Capture-MS Homo sapiens
4 ESR1  
Invivo Homo sapiens
5 STUB1  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 RAF1 5894
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 AR 367
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 VDR  
Invivo Homo sapiens
9 RARA 5914
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
10 NR3C1 2908
Invitro Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
11 BCL2  
Invitro Homo sapiens
12 PDGFRB 5159
Affinity Capture-MS Homo sapiens
13 HBEGF  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
14 HSPA1A  
Reconstituted Complex Homo sapiens
15 PPP1R15A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
16 HSPA8 3312
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 BCL2L1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BAG1 is involved
PathwayEvidenceSource
Regulation of HSF1-mediated heat shock response TAS Reactome





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