Gene description for COPS6
Gene name COP9 signalosome subunit 6
Gene symbol COPS6
Other names/aliases CSN6
MOV34-34KD
Species Homo sapiens
 Database cross references - COPS6
ExoCarta ExoCarta_10980
Entrez Gene 10980
HGNC 21749
MIM 614729
UniProt Q7L5N1  
 COPS6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for COPS6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    viral process GO:0016032 IEA
    cullin deneddylation GO:0010388 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 IDA
    COP9 signalosome GO:0008180 IDA
 Experiment description of studies that identified COPS6 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COPS6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PBX2  
Affinity Capture-MS Homo sapiens
2 COPS8 10920
Co-purification Homo sapiens
3 CDH10  
Two-hybrid Homo sapiens
4 ROGDI 79641
Two-hybrid Homo sapiens
5 DLEU1  
Two-hybrid Homo sapiens
6 TRDMT1  
Two-hybrid Homo sapiens
7 PRKRA 8575
Two-hybrid Homo sapiens
8 COX17  
Two-hybrid Homo sapiens
9 ZNF24  
Two-hybrid Homo sapiens
10 EMD  
Two-hybrid Homo sapiens
11 PSAP 5660
Two-hybrid Homo sapiens
12 SMN1 6606
Two-hybrid Homo sapiens
13 LAMA4 3910
Two-hybrid Homo sapiens
14 SULT1E1  
Two-hybrid Homo sapiens
15 TK1 7083
Two-hybrid Homo sapiens
16 COX5A  
Two-hybrid Homo sapiens
17 PAEP  
Two-hybrid Homo sapiens
18 CRELD1  
Two-hybrid Homo sapiens
19 C7orf19  
Two-hybrid Homo sapiens
20 ERH 2079
Two-hybrid Homo sapiens
21 ZFHX1B  
Two-hybrid Homo sapiens
22 PSMD11 5717
Two-hybrid Homo sapiens
23 EDN1  
Two-hybrid Homo sapiens
24 HMOX2 3163
Two-hybrid Homo sapiens
25 HSU79303  
Two-hybrid Homo sapiens
26 SLC2A1 6513
Two-hybrid Homo sapiens
27 RPL15 6138
Two-hybrid Homo sapiens
28 SAT  
Two-hybrid Homo sapiens
29 S100A10 6281
Two-hybrid Homo sapiens
30 RFC5 5985
Two-hybrid Homo sapiens
31 SERPINB9 5272
Two-hybrid Homo sapiens
32 FAU  
Two-hybrid Homo sapiens
33 PMF1  
Two-hybrid Homo sapiens
34 DIS3L2 129563
Two-hybrid Homo sapiens
35 FLJ10350  
Two-hybrid Homo sapiens
36 BTBD2  
Two-hybrid Homo sapiens
37 PHYHIP 9796
Two-hybrid Homo sapiens
38 PFKL 5211
Two-hybrid Homo sapiens
39 C1orf174  
Two-hybrid Homo sapiens
40 MNAT1  
Two-hybrid Homo sapiens
41 RPA2 6118
Two-hybrid Homo sapiens
42 STK40  
Two-hybrid Homo sapiens
43 PAFAH1B3 5050
Two-hybrid Homo sapiens
44 PTEN  
Two-hybrid Homo sapiens
45 SNRPG 6637
Two-hybrid Homo sapiens
46 TRIB3  
Two-hybrid Homo sapiens
47 PDZK1IP1 10158
Two-hybrid Homo sapiens
48 STX5A  
Two-hybrid Homo sapiens
49 QTRT1 81890
Two-hybrid Homo sapiens
50 TDGF1  
Two-hybrid Homo sapiens
51 SERPINA5 5104
Two-hybrid Homo sapiens
52 C4orf17  
Two-hybrid Homo sapiens
53 LPL 4023
Two-hybrid Homo sapiens
54 MYCBP  
Two-hybrid Homo sapiens
55 EIF3E 3646
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
56 WIPI-2  
Two-hybrid Homo sapiens
57 RAB27A 5873
Two-hybrid Homo sapiens
58 CDKN2C  
Two-hybrid Homo sapiens
59 EP300 2033
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which COPS6 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here