Gene description for SREK1
Gene name splicing regulatory glutamine/lysine-rich protein 1
Gene symbol SREK1
Other names/aliases SFRS12
SRrp508
SRrp86
Species Homo sapiens
 Database cross references - SREK1
ExoCarta ExoCarta_140890
Vesiclepedia VP_140890
Entrez Gene 140890
HGNC 17882
MIM 609268
UniProt Q8WXA9  
 SREK1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SREK1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    spliceosomal complex GO:0005681 IEA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified SREK1 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SREK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 ZNF668  
Affinity Capture-MS Homo sapiens
3 RPSAP58 388524
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 HNRNPC 3183
Affinity Capture-MS Homo sapiens
6 INO80B 83444
Affinity Capture-MS Homo sapiens
7 DNAJC8 22826
Proximity Label-MS Homo sapiens
8 RPS3A 6189
Affinity Capture-MS Homo sapiens
9 SRPK2 6733
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPL13A 23521
Affinity Capture-MS Homo sapiens
11 RPL37A 6168
Affinity Capture-MS Homo sapiens
12 DDX17 10521
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
13 PAIP2B  
Affinity Capture-MS Homo sapiens
14 RPS19 6223
Affinity Capture-MS Homo sapiens
15 MRPL37 51253
Two-hybrid Homo sapiens
16 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
17 SRSF2 6427
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
18 PRPF40A 55660
Two-hybrid Homo sapiens
19 SRSF8 10929
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PCBP3 54039
Two-hybrid Homo sapiens
21 RPS3 6188
Affinity Capture-MS Homo sapiens
22 SAFB 6294
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
23 DDX23 9416
Proximity Label-MS Homo sapiens
24 RPL10A 4736
Affinity Capture-MS Homo sapiens
25 RNPS1 10921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CHCHD10  
Affinity Capture-MS Homo sapiens
27 SNRPC 6631
Affinity Capture-MS Homo sapiens
28 RPS8 6202
Affinity Capture-MS Homo sapiens
29 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DNAJB1 3337
Proximity Label-MS Homo sapiens
31 PRKRA 8575
Affinity Capture-MS Homo sapiens
32 SNRPD3 6634
Affinity Capture-MS Homo sapiens
33 ZNF346  
Affinity Capture-MS Homo sapiens
34 MECP2 4204
Affinity Capture-MS Homo sapiens
35 CUL1 8454
Affinity Capture-MS Homo sapiens
36 TARBP1 6894
Two-hybrid Homo sapiens
37 SREK1 140890
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 PABPC4 8761
Affinity Capture-MS Homo sapiens
39 RPL19 6143
Affinity Capture-MS Homo sapiens
40 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RBMX 27316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
42 E2F4  
Affinity Capture-MS Homo sapiens
43 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 DGKD 8527
Two-hybrid Homo sapiens
45 RPS10 6204
Affinity Capture-MS Homo sapiens
46 SPATA1  
Affinity Capture-MS Homo sapiens
47 SRSF3 6428
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
48 YBX2 51087
Affinity Capture-MS Homo sapiens
49 SRSF6 6431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PURG  
Affinity Capture-MS Homo sapiens
51 IFI27L1  
Affinity Capture-MS Homo sapiens
52 ACACA 31
Positive Genetic Homo sapiens
53 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
54 RPL35 11224
Affinity Capture-MS Homo sapiens
55 PABPC1 26986
Affinity Capture-MS Homo sapiens
56 SNRPD1 6632
Affinity Capture-MS Homo sapiens
57 NTRK1 4914
Affinity Capture-MS Homo sapiens
58 RPL31 6160
Affinity Capture-MS Homo sapiens
59 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
60 LUC7L2 51631
Affinity Capture-MS Homo sapiens
61 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
62 SRPK3  
Affinity Capture-MS Homo sapiens
63 MAGEB2 4113
Affinity Capture-MS Homo sapiens
64 DDX39B 7919
Affinity Capture-MS Homo sapiens
65 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 FGF13  
Affinity Capture-MS Homo sapiens
67 SRPK1 6732
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
68 RBM10  
Affinity Capture-MS Homo sapiens
69 FGFBP1 9982
Affinity Capture-MS Homo sapiens
70 SRSF11 9295
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 HNRNPD 3184
Affinity Capture-MS Homo sapiens
72 SFPQ 6421
Affinity Capture-MS Homo sapiens
73 RBM39 9584
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
74 ARL6IP4  
Two-hybrid Homo sapiens
75 MUS81  
Synthetic Growth Defect Homo sapiens
76 RPS2 6187
Affinity Capture-MS Homo sapiens
77 LMNB1 4001
Affinity Capture-MS Homo sapiens
78 RC3H2  
Affinity Capture-MS Homo sapiens
79 ECT2 1894
Affinity Capture-MS Homo sapiens
80 PNN 5411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 SRSF4 6429
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 NAT10 55226
Two-hybrid Homo sapiens
83 SRSF1 6426
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CKAP2  
Two-hybrid Homo sapiens
85 SRRM4  
Two-hybrid Homo sapiens
86 CIT 11113
Affinity Capture-MS Homo sapiens
87 SRSF5 6430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 RPL3 6122
Affinity Capture-MS Homo sapiens
89 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
90 GPRASP2  
Two-hybrid Homo sapiens
91 EFTUD2 9343
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
92 RPL36 25873
Affinity Capture-MS Homo sapiens
93 Dusp14  
Two-hybrid Mus musculus
94 RPA3 6119
Proximity Label-MS Homo sapiens
95 DNAJC9 23234
Proximity Label-MS Homo sapiens
96 RPL22 6146
Affinity Capture-MS Homo sapiens
97 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SH3GLB2 56904
Two-hybrid Homo sapiens
99 SRSF10 10772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SF3B3 23450
Affinity Capture-MS Homo sapiens
101 HNRNPU 3192
Affinity Capture-MS Homo sapiens
102 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ZC3H3  
Affinity Capture-MS Homo sapiens
104 BRD3 8019
Affinity Capture-MS Homo sapiens
105 SUPT16H 11198
Affinity Capture-MS Homo sapiens
106 MDM2  
Reconstituted Complex Homo sapiens
107 SF3A3 10946
Affinity Capture-MS Homo sapiens
108 PAIP1 10605
Affinity Capture-MS Homo sapiens
109 RPL13 6137
Affinity Capture-MS Homo sapiens
110 YBX1 4904
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
111 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
112 PARP1 142
Affinity Capture-MS Homo sapiens
113 ZRANB2 9406
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 RRS1 23212
Affinity Capture-MS Homo sapiens
115 FOLR1 2348
Affinity Capture-MS Homo sapiens
116 RBM25 58517
Co-fractionation Homo sapiens
117 SSRP1 6749
Affinity Capture-MS Homo sapiens
118 DDX3X 1654
Affinity Capture-MS Homo sapiens
119 SRSF9 8683
Affinity Capture-MS Homo sapiens
120 SAP18 10284
Affinity Capture-MS Homo sapiens
121 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
122 DGCR8  
Affinity Capture-MS Homo sapiens
123 THRAP3 9967
Affinity Capture-MS Homo sapiens
124 IFI6  
Affinity Capture-MS Homo sapiens
125 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
126 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
127 PUF60 22827
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
128 TRA2B 6434
Affinity Capture-MS Homo sapiens
129 MAGEA9  
Affinity Capture-MS Homo sapiens
130 NIFK 84365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 HNRNPK 3190
Affinity Capture-MS Homo sapiens
132 VPS33A 65082
Co-fractionation Homo sapiens
133 C20orf197  
Affinity Capture-MS Homo sapiens
134 SNRNP40 9410
Co-fractionation Homo sapiens
135 NEIL1  
Affinity Capture-MS Homo sapiens
136 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
137 NCL 4691
Affinity Capture-MS Homo sapiens
138 SRSF7 6432
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
139 ZCCHC10  
Affinity Capture-MS Homo sapiens
140 RPS6 6194
Affinity Capture-MS Homo sapiens
141 C1QBP 708
Affinity Capture-MS Homo sapiens
142 RPL23A 6147
Affinity Capture-MS Homo sapiens
143 RAB5C 5878
Two-hybrid Homo sapiens
144 GNB2L1 10399
Affinity Capture-MS Homo sapiens
145 RC3H1 149041
Affinity Capture-MS Homo sapiens
146 SNRPA1 6627
Affinity Capture-MS Homo sapiens
147 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SREK1 is involved
No pathways found





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