Gene description for PRNP
Gene name	prion protein
Gene symbol	PRNP
Other names/aliases	ASCR AltPrP CD230 CJD GSS KURU PRIP PrP PrP27-30 PrP33-35C PrPc p27-30
Species	Homo sapiens
Database cross references - PRNP
ExoCarta	ExoCarta_5621
Entrez Gene	5621
HGNC	9449
MIM	176640
UniProt	F7VJQ1   P04156
PRNP identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Urine	19056867

Gene ontology annotations for PRNP

Molecular Function     identical protein binding GO:0042802 IPI     tubulin binding GO:0015631 IDA     microtubule binding GO:0008017 IDA     ATP-dependent protein binding GO:0043008 IEA     chaperone binding GO:0051087 IEA     copper ion binding GO:0005507 TAS     protein binding GO:0005515 IPI Biological Process     protein homooligomerization GO:0051260 IEA     negative regulation of apoptotic process GO:0043066 IEA     cell cycle arrest GO:0007050 IEA     negative regulation of interleukin-17 production GO:0032700 ISS     negative regulation of interleukin-2 production GO:0032703 ISS     cellular copper ion homeostasis GO:0006878 NAS     response to cadmium ion GO:0046686 IEA     cellular response to copper ion GO:0071280 IDA     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 ISS     regulation of potassium ion transmembrane transport GO:1901379 IEA     axon guidance GO:0007411 TAS     response to oxidative stress GO:0006979 ISS     negative regulation of activated T cell proliferation GO:0046007 ISS     negative regulation of interferon-gamma production GO:0032689 ISS     negative regulation of protein phosphorylation GO:0001933 ISS     regulation of protein localization GO:0032880 IEA     learning or memory GO:0007611 IEA     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISS     metabolic process GO:0008152 TAS     negative regulation of T cell receptor signaling pathway GO:0050860 ISS Subcellular Localization     nucleus GO:0005634 IEA     Golgi apparatus GO:0005794 ISS     plasma membrane GO:0005886 ISS     mitochondrial outer membrane GO:0005741 IDA     endoplasmic reticulum GO:0005783 ISS     integral component of membrane GO:0016021 IEA     membrane raft GO:0045121 ISS     cell surface GO:0009986 IDA     extrinsic component of membrane GO:0019898 TAS     cytoplasm GO:0005737 TAS     extracellular exosome GO:0070062 IDA     anchored component of membrane GO:0031225 IEA