Gene description for ACAD11
Gene name acyl-CoA dehydrogenase family, member 11
Gene symbol ACAD11
Other names/aliases ACAD-11
Species Homo sapiens
 Database cross references - ACAD11
ExoCarta ExoCarta_84129
Vesiclepedia VP_84129
Entrez Gene 84129
HGNC 30211
MIM 614288
UniProt Q709F0  
 ACAD11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ACAD11
Molecular Function
    acyl-CoA dehydrogenase activity GO:0003995 IBA
    acyl-CoA dehydrogenase activity GO:0003995 TAS
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IDA
    protein binding GO:0005515 IPI
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IDA
    flavin adenine dinucleotide binding GO:0050660 IEA
    medium-chain fatty acyl-CoA dehydrogenase activity GO:0070991 IDA
Biological Process
    fatty acid beta-oxidation GO:0006635 TAS
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IBA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IBA
    mitochondrial inner membrane GO:0005743 TAS
    peroxisome GO:0005777 ISS
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified ACAD11 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ACAD11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
2 ANKLE2 23141
Affinity Capture-MS Homo sapiens
3 STK25 10494
Affinity Capture-MS Homo sapiens
4 PDYN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MED17  
Affinity Capture-MS Homo sapiens
6 MAGEA3  
Affinity Capture-MS Homo sapiens
7 MED7  
Affinity Capture-MS Homo sapiens
8 MED6  
Affinity Capture-MS Homo sapiens
9 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MED29  
Affinity Capture-MS Homo sapiens
11 COPRS  
Affinity Capture-MS Homo sapiens
12 CFC1  
Affinity Capture-MS Homo sapiens
13 MED9  
Affinity Capture-MS Homo sapiens
14 MED13L 23389
Affinity Capture-MS Homo sapiens
15 BRD2  
Affinity Capture-MS Homo sapiens
16 MED24 9862
Affinity Capture-MS Homo sapiens
17 CNTN5 53942
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TINAG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 APP 351
Reconstituted Complex Homo sapiens
20 ILF2 3608
Affinity Capture-MS Homo sapiens
21 JAZF1  
Affinity Capture-MS Homo sapiens
22 MED12L  
Affinity Capture-MS Homo sapiens
23 MED13 9969
Affinity Capture-MS Homo sapiens
24 SDHB 6390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ISY1 57461
Affinity Capture-MS Homo sapiens
26 PPP6R1 22870
Affinity Capture-MS Homo sapiens
27 MED27  
Affinity Capture-MS Homo sapiens
28 NR3C1 2908
Proximity Label-MS Homo sapiens
29 C4orf22  
Affinity Capture-MS Homo sapiens
30 MED22  
Affinity Capture-MS Homo sapiens
31 PTPN14 5784
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GTSE1 51512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 IL17RA 23765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NSFL1C 55968
Affinity Capture-MS Homo sapiens
35 PPP6R3 55291
Affinity Capture-MS Homo sapiens
36 SOX5 6660
Affinity Capture-MS Homo sapiens
37 KIF14 9928
Affinity Capture-MS Homo sapiens
38 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 MED4 29079
Affinity Capture-MS Homo sapiens
40 MED1 5469
Affinity Capture-MS Homo sapiens
41 BEX2  
Affinity Capture-MS Homo sapiens
42 MED20 9477
Affinity Capture-MS Homo sapiens
43 TTC4  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
44 TRAFD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PARK2  
Affinity Capture-MS Homo sapiens
46 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 DRG1 4733
Affinity Capture-MS Homo sapiens
48 FAM9A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MED26  
Affinity Capture-MS Homo sapiens
50 GPBP1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CEP85L  
Affinity Capture-MS Homo sapiens
52 RPS16 6217
Affinity Capture-MS Homo sapiens
53 MED31  
Affinity Capture-MS Homo sapiens
54 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FAM124A  
Affinity Capture-MS Homo sapiens
56 LYPD4  
Affinity Capture-MS Homo sapiens
57 MTMR4  
Affinity Capture-MS Homo sapiens
58 HSPB8 26353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ZNF8  
Affinity Capture-MS Homo sapiens
60 MED15  
Affinity Capture-MS Homo sapiens
61 PICK1  
Affinity Capture-MS Homo sapiens
62 PER2  
Affinity Capture-MS Homo sapiens
63 CDK19 23097
Affinity Capture-MS Homo sapiens
64 NR4A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CCNC  
Affinity Capture-MS Homo sapiens
66 TMOD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TBKBP1  
Affinity Capture-MS Homo sapiens
68 UBXN7 26043
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
69 CD2BP2 10421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 PHIP 55023
Affinity Capture-MS Homo sapiens
71 ASAP3 55616
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TMEM194A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MED19  
Affinity Capture-MS Homo sapiens
74 EMX2  
Affinity Capture-MS Homo sapiens
75 POLR3E 55718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PSD4  
Affinity Capture-MS Homo sapiens
77 DCAF8 50717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PTPN7 5778
Affinity Capture-MS Homo sapiens
79 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CUL9  
Affinity Capture-MS Homo sapiens
81 MED10  
Affinity Capture-MS Homo sapiens
82 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 PSPC1 55269
Affinity Capture-MS Homo sapiens
84 FAM64A 54478
Affinity Capture-MS Homo sapiens
85 DCAF8L2  
Affinity Capture-MS Homo sapiens
86 SART3 9733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 AMOT 154796
Affinity Capture-MS Homo sapiens
88 MIER2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 C7orf60 154743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 GNB2L1 10399
Affinity Capture-MS Homo sapiens
91 MED14  
Affinity Capture-MS Homo sapiens
92 IFT22 64792
Affinity Capture-MS Homo sapiens
93 MED11  
Affinity Capture-MS Homo sapiens
94 DUSP19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 HECTD1 25831
Affinity Capture-MS Homo sapiens
96 TRAK2 66008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 LRFN2  
Affinity Capture-MS Homo sapiens
98 PDIA5 10954
Affinity Capture-MS Homo sapiens
99 ABCG1  
Affinity Capture-MS Homo sapiens
100 CDK8 1024
Affinity Capture-MS Homo sapiens
101 URGCP 55665
Affinity Capture-MS Homo sapiens
102 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
103 ZMYM5 9205
Affinity Capture-MS Homo sapiens
104 MED8  
Affinity Capture-MS Homo sapiens
105 SLC7A6OS  
Affinity Capture-MS Homo sapiens
106 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
107 ELFN2 114794
Affinity Capture-MS Homo sapiens
108 DDX58 23586
Affinity Capture-RNA Homo sapiens
109 MED30  
Affinity Capture-MS Homo sapiens
110 MED16 10025
Affinity Capture-MS Homo sapiens
111 KHDRBS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 MED18  
Affinity Capture-MS Homo sapiens
113 MED21  
Affinity Capture-MS Homo sapiens
114 TCL1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 MED12  
Affinity Capture-MS Homo sapiens
116 BEX1  
Affinity Capture-MS Homo sapiens
117 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 PTGES3 10728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 PEX5 5830
Affinity Capture-MS Homo sapiens
120 SLBP  
Affinity Capture-MS Homo sapiens
121 PRMT1 3276
Affinity Capture-MS Homo sapiens
122 AGPS 8540
Proximity Label-MS Homo sapiens
123 MED28  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ACAD11 is involved
PathwayEvidenceSource
Fatty acid metabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Mitochondrial Fatty Acid Beta-Oxidation TAS Reactome





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