Gene description for HIPK3
Gene name homeodomain interacting protein kinase 3
Gene symbol HIPK3
Other names/aliases DYRK6
Species Homo sapiens
 Database cross references - HIPK3
ExoCarta ExoCarta_10114
Entrez Gene 10114
HGNC 4915
MIM 604424
UniProt Q9H422  
 HIPK3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HIPK3
Molecular Function
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 ISS
Biological Process
    apoptotic process GO:0006915 IEA
    peptidyl-serine phosphorylation GO:0018105 ISS
    protein phosphorylation GO:0006468 IDA
    negative regulation of JUN kinase activity GO:0043508 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    peptidyl-threonine phosphorylation GO:0018107 ISS
    mRNA transcription GO:0009299 IDA
Subcellular Localization
    PML body GO:0016605 IEA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified HIPK3 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HIPK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FADD 8772
Affinity Capture-Western Homo sapiens
2 TP53  
Two-hybrid Homo sapiens
3 FAS 355
Affinity Capture-Western Homo sapiens
4 SUMO1 7341
Two-hybrid Homo sapiens
5 TP73  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HIPK3 is involved
No pathways found

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