Gene description for TSC22D4
Gene name TSC22 domain family, member 4
Gene symbol TSC22D4
Other names/aliases THG-1
THG1
TILZ2
Species Homo sapiens
 Database cross references - TSC22D4
ExoCarta ExoCarta_81628
Vesiclepedia VP_81628
Entrez Gene 81628
HGNC 21696
MIM 611914
UniProt Q9Y3Q8  
 TSC22D4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSC22D4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    response to osmotic stress GO:0006970 IBA
    glucose homeostasis GO:0042593 ISS
    negative regulation of DNA-templated transcription GO:0045892 NAS
    neuron cellular homeostasis GO:0070050 ISS
    neuron projection extension GO:1990138 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    dendrite GO:0030425 ISS
    synapse GO:0045202 ISS
 Experiment description of studies that identified TSC22D4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSC22D4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKAA1 5562
Two-hybrid Homo sapiens
2 WDR6 11180
Affinity Capture-MS Homo sapiens
3 MYLIP  
Two-hybrid Homo sapiens
4 TCEB1 6921
Affinity Capture-MS Homo sapiens
5 WNK1 65125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 AES 166
Two-hybrid Homo sapiens
7 P4HA2 8974
Affinity Capture-MS Homo sapiens
8 TEX11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 STK39 27347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ENKD1  
Two-hybrid Homo sapiens
11 CCDC42  
Two-hybrid Homo sapiens
12 KPNA2 3838
Two-hybrid Homo sapiens
13 TRIM55  
Two-hybrid Homo sapiens
14 LMO2  
Two-hybrid Homo sapiens
15 CCNK  
Two-hybrid Homo sapiens
16 PPL 5493
Two-hybrid Homo sapiens
17 ABLIM1 3983
Two-hybrid Homo sapiens
18 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 KRT40  
Two-hybrid Homo sapiens
20 RHOA 387
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 APIP 51074
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
22 P3H1 64175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 LHX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PDPR 55066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MAD2L1 4085
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ARHGAP9 64333
Two-hybrid Homo sapiens
29 NIF3L1 60491
Two-hybrid Homo sapiens
30 PRNP 5621
Two-hybrid Homo sapiens
31 P4HA1 5033
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MTHFS 10588
Two-hybrid Homo sapiens
33 LANCL1 10314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CDC23 8697
Two-hybrid Homo sapiens
35 SH2B3  
Affinity Capture-MS Homo sapiens
36 CLU 1191
Two-hybrid Homo sapiens
37 CCDC33 80125
Two-hybrid Homo sapiens
38 GOLGA2 2801
Two-hybrid Homo sapiens
39 CPVL 54504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 LRWD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MYO15B 80022
Two-hybrid Homo sapiens
42 GORASP2 26003
Two-hybrid Homo sapiens
43 ZNF580  
Two-hybrid Homo sapiens
44 CDK5R1  
Two-hybrid Homo sapiens
45 IFT172 26160
Affinity Capture-MS Homo sapiens
46 SAT1  
Two-hybrid Homo sapiens
47 TRIM63  
Two-hybrid Homo sapiens
48 NRBP2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CTNNAL1 8727
Two-hybrid Homo sapiens
50 TTL 150465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 AIFM1 9131
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
53 SMG8 55181
Affinity Capture-MS Homo sapiens
54 ZBTB24  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 NOC4L 79050
Two-hybrid Homo sapiens
56 PRKAA2 5563
Two-hybrid Homo sapiens
57 MAD2L1BP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TCL1A  
Affinity Capture-MS Homo sapiens
59 HNRNPA1 3178
Cross-Linking-MS (XL-MS) Homo sapiens
60 VBP1 7411
Two-hybrid Homo sapiens
61 ZMYND10 51364
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
62 PRKACA 5566
Proximity Label-MS Homo sapiens
63 NRBP1 29959
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PCBP1 5093
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
65 ZNF558  
Affinity Capture-MS Homo sapiens
66 UBLCP1  
Two-hybrid Homo sapiens
67 FXR2 9513
Two-hybrid Homo sapiens
68 CRTAP 10491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 P3H2  
Affinity Capture-MS Homo sapiens
70 TBL1X 6907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CDC45  
Affinity Capture-MS Homo sapiens
72 TCEB2 6923
Affinity Capture-MS Homo sapiens
73 TSC22D2 9819
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RANBP1 5902
Cross-Linking-MS (XL-MS) Homo sapiens
75 TSC22D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 FRMD6 122786
Two-hybrid Homo sapiens
77 LMO1  
Two-hybrid Homo sapiens
78 SACS 26278
Two-hybrid Homo sapiens
79 PRKD2 25865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 FAM175B 23172
Affinity Capture-MS Homo sapiens
82 CA10  
Affinity Capture-MS Homo sapiens
83 CCDC146  
Two-hybrid Homo sapiens
84 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 POLR1C 9533
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
86 BZRAP1  
Two-hybrid Homo sapiens
87 BLZF1  
Two-hybrid Homo sapiens
88 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
89 SYT17  
Two-hybrid Homo sapiens
90 DDX58 23586
Affinity Capture-RNA Homo sapiens
91 PSMA1 5682
Two-hybrid Homo sapiens
92 WNK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TSC22D1 8848
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 LBP 3929
Two-hybrid Homo sapiens
95 PSMA7 5688
Affinity Capture-MS Homo sapiens
96 POLR3D  
Affinity Capture-MS Homo sapiens
97 CBX8 57332
Two-hybrid Homo sapiens
98 PIH1D1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 SMAD3 4088
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
100 GNB2L1 10399
Two-hybrid Homo sapiens
101 CKS2  
Two-hybrid Homo sapiens
102 WNK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PCDH17  
Two-hybrid Homo sapiens
104 KEAP1 9817
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 LNX1  
Two-hybrid Homo sapiens
106 C1orf146  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSC22D4 is involved
No pathways found





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