Gene description for IFIT3
Gene name interferon-induced protein with tetratricopeptide repeats 3
Gene symbol IFIT3
Other names/aliases CIG-49
GARG-49
IFI60
IFIT4
IRG2
ISG60
P60
RIG-G
Species Homo sapiens
 Database cross references - IFIT3
ExoCarta ExoCarta_3437
Entrez Gene 3437
HGNC 5411
MIM 604650
UniProt O14879  
 IFIT3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for IFIT3
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    molecular_function GO:0003674 ND
Biological Process
    cytokine-mediated signaling pathway GO:0019221 TAS
    defense response to virus GO:0051607 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    type I interferon signaling pathway GO:0060337 TAS
    cellular response to interferon-alpha GO:0035457 IEA
    negative regulation of cell proliferation GO:0008285 IDA
    response to virus GO:0009615 IMP
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IFIT3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IFIT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFIT2 3433
Two-hybrid Homo sapiens
2 IFIT1 3434
Two-hybrid Homo sapiens
3 FLJ25393  
Two-hybrid Homo sapiens
4 FANCA  
Two-hybrid Homo sapiens
5 IFIT3 3437
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IFIT3 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here