Gene description for LARP7
Gene name La ribonucleoprotein domain family, member 7
Gene symbol LARP7
Other names/aliases ALAZS
HDCMA18P
PIP7S
Species Homo sapiens
 Database cross references - LARP7
ExoCarta ExoCarta_51574
Vesiclepedia VP_51574
Entrez Gene 51574
HGNC 24912
MIM 612026
UniProt Q4G0J3  
 LARP7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for LARP7
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    protein binding GO:0005515 IPI
    U6 snRNA binding GO:0017070 IDA
    7SK snRNA binding GO:0097322 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    box C/D sno(s)RNA 3'-end processing GO:0000494 IMP
    mRNA processing GO:0006397 IEA
    spermatogenesis GO:0007283 ISS
    RNA splicing GO:0008380 IEA
    cell differentiation GO:0030154 IEA
    negative regulation of viral transcription GO:0032897 IMP
    negative regulation of transcription elongation by RNA polymerase II GO:0034244 IC
    regulation of mRNA splicing, via spliceosome GO:0048024 IMP
    positive regulation of protein localization to Cajal body GO:1904871 IDA
    positive regulation of snRNA transcription by RNA polymerase II GO:1905382 IDA
    U6 2'-O-snRNA methylation GO:1990438 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    7SK snRNP GO:0120259 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified LARP7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LARP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SRP19 6728
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 RPSAP58 388524
Affinity Capture-MS Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 H1FNT  
Affinity Capture-MS Homo sapiens
7 CD3EAP  
Proximity Label-MS Homo sapiens
8 ZFX  
Affinity Capture-MS Homo sapiens
9 MED17  
Affinity Capture-MS Homo sapiens
10 PAXIP1  
Affinity Capture-MS Homo sapiens
11 RPS3A 6189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RABEP2 79874
Co-fractionation Homo sapiens
13 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
14 TGS1  
Affinity Capture-MS Homo sapiens
15 KPNB1 3837
Affinity Capture-MS Homo sapiens
16 Ybx1 22608
Affinity Capture-MS Mus musculus
17 ACTC1 70
Proximity Label-MS Homo sapiens
18 SF3B1 23451
Affinity Capture-MS Homo sapiens
19 NOP56 10528
Proximity Label-MS Homo sapiens
20 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RPS19 6223
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 BRD2  
Affinity Capture-MS Homo sapiens
23 ZNF71  
Affinity Capture-MS Homo sapiens
24 CSNK2A1 1457
Biochemical Activity Homo sapiens
25 PNMAL1  
Affinity Capture-MS Homo sapiens
26 CAND1 55832
Affinity Capture-MS Homo sapiens
27 HNRNPR 10236
Co-fractionation Homo sapiens
28 ZNF92  
Affinity Capture-MS Homo sapiens
29 AFF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 PRPF40A 55660
Two-hybrid Homo sapiens
31 SNRPF 6636
Affinity Capture-MS Homo sapiens
32 UTP3 57050
Affinity Capture-MS Homo sapiens
33 SOX2  
Affinity Capture-MS Homo sapiens
34 APP 351
Reconstituted Complex Homo sapiens
35 RPS3 6188
Affinity Capture-MS Homo sapiens
36 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
37 USP36  
Affinity Capture-MS Homo sapiens
38 HP1BP3 50809
Affinity Capture-MS Homo sapiens
39 DAXX  
Affinity Capture-MS Homo sapiens
40 RPS9 6203
Affinity Capture-MS Homo sapiens
41 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TRIM28 10155
Co-fractionation Homo sapiens
44 LLPH  
Affinity Capture-MS Homo sapiens
45 DDX24 57062
Affinity Capture-MS Homo sapiens
46 ZNF485  
Affinity Capture-MS Homo sapiens
47 CD2AP 23607
Co-fractionation Homo sapiens
48 SPAG9 9043
Co-fractionation Homo sapiens
49 DRG1 4733
Affinity Capture-MS Homo sapiens
50 BRCC3 79184
Co-fractionation Homo sapiens
51 SNRPC 6631
Affinity Capture-MS Homo sapiens
52 FBL 2091
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 H2AFY2 55506
Affinity Capture-MS Homo sapiens
54 OBSL1 23363
Affinity Capture-MS Homo sapiens
55 DDOST 1650
Affinity Capture-MS Homo sapiens
56 ZBTB11  
Affinity Capture-MS Homo sapiens
57 SRSF3 6428
Affinity Capture-MS Homo sapiens
58 ZCCHC3  
Affinity Capture-MS Homo sapiens
59 PRKRA 8575
Affinity Capture-MS Homo sapiens
60 TULP3 7289
Affinity Capture-MS Homo sapiens
61 Nhp2l1 20826
Affinity Capture-MS Mus musculus
62 PATZ1  
Affinity Capture-MS Homo sapiens
63 SRP68 6730
Affinity Capture-MS Homo sapiens
64 E4F1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ZNF346  
Affinity Capture-MS Homo sapiens
66 NSD1  
Affinity Capture-MS Homo sapiens
67 MYCN  
Affinity Capture-MS Homo sapiens
68 RBM42  
Affinity Capture-MS Homo sapiens
69 OASL 8638
Affinity Capture-MS Homo sapiens
70 CHERP 10523
Affinity Capture-MS Homo sapiens
71 ICE2  
Affinity Capture-MS Homo sapiens
72 PURB 5814
Affinity Capture-MS Homo sapiens
73 MTA2 9219
Co-fractionation Homo sapiens
74 RBM8A 9939
Affinity Capture-MS Homo sapiens
75 KIF14 9928
Affinity Capture-MS Homo sapiens
76 LARP4B 23185
Affinity Capture-MS Homo sapiens
77 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 HEXIM1 10614
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
79 AURKA 6790
Affinity Capture-MS Homo sapiens
80 SRP9 6726
Affinity Capture-MS Homo sapiens
81 JMJD6 23210
Two-hybrid Homo sapiens
82 DDX21 9188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 LIN28B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 TUT1  
Affinity Capture-MS Homo sapiens
85 PINX1  
Affinity Capture-MS Homo sapiens
86 MEPCE 56257
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 ZBTB47  
Affinity Capture-MS Homo sapiens
88 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 YBX2 51087
Affinity Capture-MS Homo sapiens
90 SRSF6 6431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PURG  
Affinity Capture-MS Homo sapiens
92 RPL5 6125
Affinity Capture-MS Homo sapiens
93 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
94 SNRPB 6628
Affinity Capture-MS Homo sapiens
95 FOXL2  
Affinity Capture-MS Homo sapiens
96 SRBD1  
Affinity Capture-MS Homo sapiens
97 BARD1 580
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
98 NTRK1 4914
Affinity Capture-MS Homo sapiens
99 RPL31 6160
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 DHX9 1660
Affinity Capture-MS Homo sapiens
101 RPS24 6229
Proximity Label-MS Homo sapiens
102 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 REXO4  
Affinity Capture-MS Homo sapiens
104 DNAJA1 3301
Affinity Capture-MS Homo sapiens
105 NCL 4691
Affinity Capture-MS Homo sapiens
106 CBX6  
Affinity Capture-MS Homo sapiens
107 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
108 DDX54 79039
Affinity Capture-MS Homo sapiens
109 LYAR 55646
Affinity Capture-MS Homo sapiens
110 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 HECTD1 25831
Affinity Capture-MS Homo sapiens
112 RPLP0 6175
Affinity Capture-MS Homo sapiens
113 VCPIP1 80124
Co-fractionation Homo sapiens
114 ATG7 10533
Co-fractionation Homo sapiens
115 PPM1G 5496
Affinity Capture-MS Homo sapiens
116 LARP1B 55132
Affinity Capture-MS Homo sapiens
117 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
118 U2SURP 23350
Affinity Capture-MS Homo sapiens
119 MRPL2 51069
Affinity Capture-MS Homo sapiens
120 BRCA1 672
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
121 KDF1  
Affinity Capture-MS Homo sapiens
122 RSL1D1 26156
Affinity Capture-MS Homo sapiens
123 FGFBP1 9982
Affinity Capture-MS Homo sapiens
124 SF3B2 10992
Affinity Capture-MS Homo sapiens
125 ZBTB2 57621
Affinity Capture-MS Homo sapiens
126 BMS1  
Affinity Capture-MS Homo sapiens
127 ABT1 29777
Affinity Capture-MS Homo sapiens
128 SRSF7 6432
Affinity Capture-MS Homo sapiens
129 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 POP1 10940
Affinity Capture-MS Homo sapiens
131 YTHDC2 64848
Affinity Capture-MS Homo sapiens
132 SIRT7  
Affinity Capture-MS Homo sapiens
133 SRSF4 6429
Affinity Capture-MS Homo sapiens
134 NAT10 55226
Affinity Capture-MS Homo sapiens
135 SRSF1 6426
Affinity Capture-MS Homo sapiens
136 ZFR 51663
Affinity Capture-MS Homo sapiens
137 NR3C1 2908
Co-fractionation Homo sapiens
138 SRSF5 6430
Affinity Capture-MS Homo sapiens
139 RPL3 6122
Affinity Capture-MS Homo sapiens
140 SSB 6741
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
141 ZC3H8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 TRIM11  
Affinity Capture-MS Homo sapiens
143 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
144 RPL35 11224
Affinity Capture-MS Homo sapiens
145 DHX37  
Affinity Capture-MS Homo sapiens
146 DHX57 90957
Affinity Capture-MS Homo sapiens
147 YTHDC1  
Affinity Capture-MS Homo sapiens
148 BAZ2A  
Affinity Capture-MS Homo sapiens
149 RSBN1  
Affinity Capture-MS Homo sapiens
150 LUC7L2 51631
Affinity Capture-MS Homo sapiens
151 RPP25  
Co-fractionation Homo sapiens
152 CMSS1  
Affinity Capture-MS Homo sapiens
153 PSPC1 55269
Affinity Capture-MS Homo sapiens
154 RPA3 6119
Proximity Label-MS Homo sapiens
155 LTV1  
Affinity Capture-MS Homo sapiens
156 NOL12 79159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 TOE1 114034
Affinity Capture-MS Homo sapiens
159 SART3 9733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
161 PARP1 142
Cross-Linking-MS (XL-MS) Homo sapiens
162 RNF2  
Affinity Capture-MS Homo sapiens
163 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
164 H2AFB2  
Affinity Capture-MS Homo sapiens
165 RPL11 6135
Affinity Capture-MS Homo sapiens
166 HAT1 8520
Co-fractionation Homo sapiens
167 CCDC140  
Affinity Capture-MS Homo sapiens
168 RPS10 6204
Affinity Capture-MS Homo sapiens
169 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
170 RPL26 6154
Affinity Capture-MS Homo sapiens
171 ZC3H3  
Affinity Capture-MS Homo sapiens
172 BRD3 8019
Affinity Capture-MS Homo sapiens
173 HUWE1 10075
Co-fractionation Homo sapiens
174 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 H2AFX 3014
Affinity Capture-MS Homo sapiens
176 RPL19 6143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 ZNF574  
Affinity Capture-MS Homo sapiens
178 YBX1 4904
Affinity Capture-MS Homo sapiens
179 SURF6  
Affinity Capture-MS Homo sapiens
180 RPS27A 6233
Affinity Capture-MS Homo sapiens
181 CTCF  
Affinity Capture-MS Homo sapiens
182 PRDM10  
Affinity Capture-MS Homo sapiens
183 TERF2  
Affinity Capture-MS Homo sapiens
184 SIRT6  
Affinity Capture-MS Homo sapiens
185 RBM19 9904
Affinity Capture-MS Homo sapiens
186 ILF3 3609
Affinity Capture-MS Homo sapiens
187 CPSF6 11052
Affinity Capture-MS Homo sapiens
188 RPL6 6128
Affinity Capture-MS Homo sapiens
189 PRDM15  
Affinity Capture-MS Homo sapiens
190 FCGRT 2217
Affinity Capture-MS Homo sapiens
191 MNDA 4332
Affinity Capture-MS Homo sapiens
192 RNF151  
Affinity Capture-MS Homo sapiens
193 CCDC86  
Affinity Capture-MS Homo sapiens
194 ZCRB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
196 SNRPA 6626
Affinity Capture-MS Homo sapiens
197 UTP23  
Affinity Capture-MS Homo sapiens
198 SRP72 6731
Affinity Capture-MS Homo sapiens
199 HDAC1 3065
Co-fractionation Homo sapiens
200 H2AFB3  
Affinity Capture-MS Homo sapiens
201 NOL10  
Affinity Capture-MS Homo sapiens
202 KRI1  
Affinity Capture-MS Homo sapiens
203 NIFK 84365
Affinity Capture-MS Homo sapiens
204 KRR1 11103
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 NEIL1  
Affinity Capture-MS Homo sapiens
206 TERF1 7013
Affinity Capture-MS Homo sapiens
207 CDK13 8621
Affinity Capture-MS Homo sapiens
208 HEXIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 TSC22D1 8848
Co-fractionation Homo sapiens
210 YBX3 8531
Affinity Capture-MS Homo sapiens
211 CDK9 1025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 PINK1  
Affinity Capture-MS Homo sapiens