Gene description for SRA1
Gene name steroid receptor RNA activator 1
Gene symbol SRA1
Other names/aliases SRA
SRAP
STRAA1
pp7684
Species Homo sapiens
 Database cross references - SRA1
ExoCarta ExoCarta_10011
Vesiclepedia VP_10011
Entrez Gene 10011
HGNC 11281
MIM 603819
UniProt Q9HD15  
 SRA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SRA1
Molecular Function
    steroid receptor RNA activator RNA binding GO:0002153 IDA
    steroid receptor RNA activator RNA binding GO:0002153 IDA
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IBA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IMP
    apoptotic process GO:0006915 IEA
    negative regulation of myoblast differentiation GO:0045662 IMP
    positive regulation of DNA-templated transcription GO:0045893 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    microtubule cytoskeleton GO:0015630 IDA
    intercellular bridge GO:0045171 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified SRA1 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SRA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Far Western Homo sapiens
2 SEC24B 10427
Affinity Capture-MS Homo sapiens
3 MAN2C1 4123
Affinity Capture-MS Homo sapiens
4 ESR2  
Far Western Homo sapiens
5 HDAC2 3066
Affinity Capture-Western Homo sapiens
6 Ercc6l  
Affinity Capture-MS Mus musculus
7 GTF3C5 9328
Far Western Homo sapiens
8 HSPA8 3312
Co-fractionation Homo sapiens
9 TFAP2A  
Far Western Homo sapiens
10 SEC24D 9871
Affinity Capture-MS Homo sapiens
11 SEC23B 10483
Affinity Capture-MS Homo sapiens
12 BLZF1  
Far Western Homo sapiens
13 POLK  
Affinity Capture-MS Homo sapiens
14 NR3C1 2908
Far Western Homo sapiens
15 TIGD6  
Affinity Capture-MS Homo sapiens
16 UBE2T  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
17 HSPA1A 3303
Co-fractionation Homo sapiens
18 SYNCRIP 10492
Co-fractionation Homo sapiens
19 DMTF1  
Far Western Homo sapiens
20 BTG2 7832
Far Western Homo sapiens
21 HNRNPA1 3178
Co-fractionation Homo sapiens
22 EGR2  
Far Western Homo sapiens
23 CREB1  
Far Western Homo sapiens
24 GTF2H2  
Far Western Homo sapiens
25 ATF1  
Far Western Homo sapiens
26 FOSL2  
Far Western Homo sapiens
27 SEC24A 10802
Affinity Capture-MS Homo sapiens
28 ESR1  
Far Western Homo sapiens
29 ATF4  
Far Western Homo sapiens
30 ATF2  
Far Western Homo sapiens
31 E2F3  
Far Western Homo sapiens
32 ALX1  
Far Western Homo sapiens
33 DDIT3 1649
Far Western Homo sapiens
34 RAET1L  
Affinity Capture-MS Homo sapiens
35 PABPC1 26986
Co-fractionation Homo sapiens
36 FOS 2353
Far Western Homo sapiens
37 SPEN 23013
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
38 ETS2  
Far Western Homo sapiens
39 SAP30 8819
Affinity Capture-MS Homo sapiens
40 HAND1  
Far Western Homo sapiens
41 EGR1  
Far Western Homo sapiens
42 ESRRG  
Far Western Homo sapiens
43 ETS1  
Far Western Homo sapiens
44 SEC24C 9632
Affinity Capture-MS Homo sapiens
45 GAPDH 2597
Co-fractionation Homo sapiens
46 EPRS 2058
Co-fractionation Homo sapiens
47 VCL 7414
Co-fractionation Homo sapiens
48 FOSB  
Far Western Homo sapiens
49 OAZ1 4946
Affinity Capture-MS Homo sapiens
50 HNRNPL 3191
Co-fractionation Homo sapiens
51 Mib1  
Affinity Capture-MS Mus musculus
52 ATF3  
Far Western Homo sapiens
53 CEBPA  
Far Western Homo sapiens
54 GTF2B 2959
Far Western Homo sapiens
55 HNRNPA2B1 3181
Co-fractionation Homo sapiens
56 RUFY1 80230
Affinity Capture-MS Homo sapiens
57 MLKL 197259
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SRA1 is involved
No pathways found





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