Gene description for XRN1
Gene name 5'-3' exoribonuclease 1
Gene symbol XRN1
Other names/aliases SEP1
Species Homo sapiens
 Database cross references - XRN1
ExoCarta ExoCarta_54464
Entrez Gene 54464
HGNC 30654
MIM 607994
UniProt Q8IZH2  
 XRN1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for XRN1
Molecular Function
    5'-3' exonuclease activity GO:0008409 IEA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IEA
    histone mRNA catabolic process GO:0071044 IMP
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    rRNA catabolic process GO:0016075 IMP
    nuclear-transcribed mRNA catabolic process GO:0000956 IMP
    nuclear mRNA surveillance GO:0071028 IMP
    gene expression GO:0010467 TAS
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    nucleus GO:0005634 IMP
    cytosol GO:0005829 TAS
    intermediate filament cytoskeleton GO:0045111 IDA
    plasma membrane GO:0005886 IDA
    cytoplasmic mRNA processing body GO:0000932 IEA
    Golgi apparatus GO:0005794 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified XRN1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for XRN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ALDOA 226
Two-hybrid Homo sapiens
2 BAG6 7917
Two-hybrid Homo sapiens
3 UPF2  
Affinity Capture-Western Homo sapiens
4 AP1G2 8906
Two-hybrid Homo sapiens
5 PABPC4 8761
Two-hybrid Homo sapiens
6 CCT5 22948
Two-hybrid Homo sapiens
7 CHD4 1108
Two-hybrid Homo sapiens
8 UPF1 5976
Affinity Capture-Western Homo sapiens
9 UPF3A  
Affinity Capture-Western Homo sapiens
10 SMARCD2 6603
Two-hybrid Homo sapiens
11 LSM4  
Two-hybrid Homo sapiens
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