Gene description for BMP2K
Gene name BMP2 inducible kinase
Gene symbol BMP2K
Other names/aliases BIKE
HRIHFB2017
Species Homo sapiens
 Database cross references - BMP2K
ExoCarta ExoCarta_55589
Vesiclepedia VP_55589
Entrez Gene 55589
HGNC 18041
UniProt Q9NSY1  
 BMP2K identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BMP2K
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phosphatase regulator activity GO:0019208 IBA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    AP-2 adaptor complex binding GO:0035612 IBA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of bone mineralization GO:0030500 IBA
    positive regulation of Notch signaling pathway GO:0045747 IBA
    regulation of clathrin-dependent endocytosis GO:2000369 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified BMP2K in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BMP2K
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GTSE1 51512
Affinity Capture-MS Homo sapiens
5 LIMA1 51474
Affinity Capture-MS Homo sapiens
6 PDLIM7 9260
Affinity Capture-MS Homo sapiens
7 ISG15 9636
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 AP2B1 163
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 Sec24c  
Affinity Capture-MS Mus musculus
11 PPP1CB 5500
Affinity Capture-MS Homo sapiens
12 TERF2  
Affinity Capture-MS Homo sapiens
13 LAMTOR1 55004
Proximity Label-MS Homo sapiens
14 MAP7 9053
Affinity Capture-MS Homo sapiens
15 CLINT1 9685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 Myh9 17886
Affinity Capture-MS Mus musculus
17 STAMBP 10617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KDM5B  
Affinity Capture-MS Homo sapiens
19 KIF14 9928
Affinity Capture-MS Homo sapiens
20 AP2S1 1175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 XPO1 7514
Affinity Capture-MS Homo sapiens
22 Tpm1 22003
Affinity Capture-MS Mus musculus
23 NINL  
Proximity Label-MS Homo sapiens
24 SEC16A 9919
Affinity Capture-MS Homo sapiens
25 APOO 79135
Proximity Label-MS Homo sapiens
26 ATG9A 79065
Proximity Label-MS Homo sapiens
27 Calml3  
Affinity Capture-MS Mus musculus
28 ABL1 25
Affinity Capture-MS Homo sapiens
29 Myo1c 17913
Affinity Capture-MS Mus musculus
30 GAK 2580
Affinity Capture-MS Homo sapiens
31 LIMS1 3987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 EPS15 2060
Affinity Capture-MS Homo sapiens
33 CAPZA2 830
Affinity Capture-MS Homo sapiens
34 SQSTM1 8878
Proximity Label-MS Homo sapiens
35 Numb  
Affinity Capture-MS Mus musculus
36 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
37 MYO19  
Affinity Capture-MS Homo sapiens
38 GBA 2629
Affinity Capture-MS Homo sapiens
39 Actb 11461
Affinity Capture-MS Mus musculus
40 CLTB 1212
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
41 MYO6 4646
Proximity Label-MS Homo sapiens
42 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FN1 2335
Affinity Capture-MS Homo sapiens
44 Myh10 77579
Affinity Capture-MS Mus musculus
45 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 APEX1 328
Affinity Capture-RNA Homo sapiens
47 CDK2 1017
Affinity Capture-MS Homo sapiens
48 TERF1 7013
Affinity Capture-MS Homo sapiens
49 SYNPO 11346
Affinity Capture-MS Homo sapiens
50 RNPS1 10921
Affinity Capture-MS Homo sapiens
51 DAB2 1601
Affinity Capture-MS Homo sapiens
52 Flnb 286940
Affinity Capture-MS Mus musculus
53 Uso1 56041
Affinity Capture-MS Mus musculus
54 MYH9 4627
Affinity Capture-MS Homo sapiens
55 DNAJC6  
Affinity Capture-MS Homo sapiens
56 FLNA 2316
Affinity Capture-MS Homo sapiens
57 CLTA 1211
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 COL8A1 1295
Affinity Capture-MS Homo sapiens
59 AP1B1 162
Affinity Capture-MS Homo sapiens
60 Flot1 14251
Affinity Capture-MS Mus musculus
61 SLURP1  
Affinity Capture-MS Homo sapiens
62 NECAP2 55707
Affinity Capture-MS Homo sapiens
63 IQGAP1 8826
Affinity Capture-MS Homo sapiens
64 STX7 8417
Proximity Label-MS Homo sapiens
65 RUNDC3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 C10orf88  
Affinity Capture-MS Homo sapiens
67 RNF166  
Affinity Capture-MS Homo sapiens
68 CLTC 1213
Affinity Capture-MS Homo sapiens
69 STAMBPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 Ppp1cb 19046
Affinity Capture-MS Mus musculus
71 REPS1 85021
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 PICALM 8301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 FHL2 2274
Affinity Capture-MS Homo sapiens
74 DBN1 1627
Affinity Capture-MS Homo sapiens
75 MYO18A 399687
Affinity Capture-MS Homo sapiens
76 STX6 10228
Proximity Label-MS Homo sapiens
77 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BMP2K is involved
No pathways found





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