Gene description for CDKN2A
Gene name cyclin-dependent kinase inhibitor 2A
Gene symbol CDKN2A
Other names/aliases ARF
CDK4I
CDKN2
CMM2
INK4
INK4A
MLM
MTS-1
MTS1
P14
P14ARF
P16
P16-INK4A
P16INK4
P16INK4A
P19
P19ARF
TP16
Species Homo sapiens
 Database cross references - CDKN2A
ExoCarta ExoCarta_1029
Vesiclepedia VP_1029
Entrez Gene 1029
HGNC 1787
MIM 600160
UniProt Q8N726   P42771  
 CDKN2A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CDKN2A
Molecular Function
    p53 binding GO:0002039 IPI
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 HDA
    cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IBA
    cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IDA
    protein binding GO:0005515 IPI
    SUMO transferase activity GO:0019789 EXP
    protein kinase binding GO:0019901 IPI
    NF-kappaB binding GO:0051059 IDA
    ubiquitin-protein transferase inhibitor activity GO:0055105 ISS
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    MDM2/MDM4 family protein binding GO:0097371 IPI
    disordered domain specific binding GO:0097718 IPI
    ubiquitin ligase inhibitor activity GO:1990948 IDA
Biological Process
    protein polyubiquitination GO:0000209 IDA
    autophagy of mitochondrion GO:0000422 IMP
    negative regulation of cell-matrix adhesion GO:0001953 IMP
    rRNA processing GO:0006364 IEA
    Ras protein signal transduction GO:0007265 IEP
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell population proliferation GO:0008285 IMP
    positive regulation of gene expression GO:0010628 IDA
    protein sumoylation GO:0016925 TAS
    negative regulation of cell growth GO:0030308 IDA
    nuclear body organization GO:0030575 EXP
    negative regulation of B cell proliferation GO:0030889 ISS
    regulation of protein stability GO:0031647 IEP
    regulation of protein stability GO:0031647 ISS
    protein destabilization GO:0031648 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of immature T cell proliferation in thymus GO:0033088 ISS
    positive regulation of protein sumoylation GO:0033235 IMP
    positive regulation of smooth muscle cell apoptotic process GO:0034393 ISS
    protein localization to nucleus GO:0034504 IDA
    negative regulation of phosphorylation GO:0042326 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 IDA
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of protein export from nucleus GO:0046825 IMP
    somatic stem cell division GO:0048103 ISS
    protein stabilization GO:0050821 IDA
    negative regulation of ubiquitin-protein transferase activity GO:0051444 ISS
    regulation of cell cycle GO:0051726 IDA
    regulation of cell cycle GO:0051726 IEA
    regulation of cell cycle GO:0051726 IMP
    mitochondrial depolarization GO:0051882 IMP
    protein K63-linked ubiquitination GO:0070534 IDA
    cellular senescence GO:0090398 IMP
    replicative senescence GO:0090399 IMP
    apoptotic signaling pathway GO:0097190 IMP
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of signal transduction by p53 class mediator GO:1901798 IDA
    protein localization to nucleolus GO:1902570 EXP
    negative regulation of proteolysis involved in protein catabolic process GO:1903051 IMP
    regulation of protein targeting to mitochondrion GO:1903214 IMP
    negative regulation of ubiquitin protein ligase activity GO:1904667 IDA
    amyloid fibril formation GO:1990000 IDA
    amyloid fibril formation GO:1990000 IMP
    regulation of G1/S transition of mitotic cell cycle GO:2000045 IBA
    regulation of G1/S transition of mitotic cell cycle GO:2000045 IDA
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 IDA
    positive regulation of macrophage apoptotic process GO:2000111 ISS
    negative regulation of protein neddylation GO:2000435 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IMP
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IDA
    protein-containing complex GO:0032991 IDA
    senescence-associated heterochromatin focus GO:0035985 IDA
 Experiment description of studies that identified CDKN2A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CDKN2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ATR  
Affinity Capture-Western Homo sapiens
3 SNRPA 6626
Reconstituted Complex Homo sapiens
4 MIS12  
Affinity Capture-MS Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Reconstituted Complex Homo sapiens
7 ISG15 9636
Affinity Capture-MS Homo sapiens
8 GMNN  
Reconstituted Complex Homo sapiens
9 SPRTN  
Affinity Capture-MS Homo sapiens
10 UBE2A  
Affinity Capture-Western Homo sapiens
11 ORC4  
Reconstituted Complex Homo sapiens
12 RIN3  
Affinity Capture-MS Homo sapiens
13 USP26  
Reconstituted Complex Homo sapiens
14 CTBP2 1488
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 E2F1 1869
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 SUB1 10923
Affinity Capture-MS Homo sapiens
18 SIVA1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 UCHL1 7345
Affinity Capture-Western Homo sapiens
20 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
21 TRADD 8717
Affinity Capture-Western Homo sapiens
22 UBC 7316
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
23 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
24 VHL  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 NCKAP1 10787
Co-fractionation Homo sapiens
26 TAF1  
Affinity Capture-MS Homo sapiens
27 SENP3 26168
Affinity Capture-Western Homo sapiens
28 CWF19L2  
Affinity Capture-MS Homo sapiens
29 PPP1CC 5501
Affinity Capture-Western Homo sapiens
30 HSPA4 3308
Reconstituted Complex Homo sapiens
31 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
32 PPP1CB 5500
Affinity Capture-Western Homo sapiens
33 HSP90AA1 3320
Reconstituted Complex Homo sapiens
34 CFAP97  
Affinity Capture-MS Homo sapiens
35 EGR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 COPS6 10980
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 CRELD2 79174
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
38 COPS5 10987
Affinity Capture-MS Homo sapiens
39 PRC1 9055
Affinity Capture-MS Homo sapiens
40 IQGAP1 8826
Affinity Capture-MS Homo sapiens
41 NPM1 4869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 BRPF3  
Affinity Capture-MS Homo sapiens
43 MCM6 4175
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
44 RNF2  
Affinity Capture-Western Homo sapiens
45 Set 56086
Affinity Capture-MS Mus musculus
46 GGA1 26088
Two-hybrid Homo sapiens
47 TTF1  
Affinity Capture-Western Homo sapiens
48 RIN2  
Reconstituted Complex Homo sapiens
49 Naa11  
Affinity Capture-MS Mus musculus
50 E4F1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
51 Bcl6  
Affinity Capture-Western Mus musculus
52 CUL1 8454
Affinity Capture-MS Homo sapiens
53 MYCN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 PDCD6 10016
Reconstituted Complex Homo sapiens
55 GAPDH 2597
Reconstituted Complex Homo sapiens
56 PSMC3 5702
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 KIF14 9928
Affinity Capture-MS Homo sapiens
58 TRIP12 9320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 HSPA8 3312
Reconstituted Complex Homo sapiens
60 DYRK1B  
Affinity Capture-MS Homo sapiens
61 WRN 7486
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
62 PSME3 10197
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 MAPK1 5594
Affinity Capture-MS Homo sapiens
64 HSPA9 3313
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
65 AURKA 6790
Affinity Capture-MS Homo sapiens
66 CLK2 1196
Affinity Capture-MS Homo sapiens
67 CDKN2AIP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
68 ING4  
Affinity Capture-Western Homo sapiens
69 UBE4B 10277
Reconstituted Complex Homo sapiens
70 Vhl  
Co-fractionation Rattus norvegicus
71 IGF1R 3480
Negative Genetic Homo sapiens
72 CDKN2B 1030
Affinity Capture-MS Homo sapiens
73 CSTF2 1478
Co-fractionation Homo sapiens
74 RSRC1  
Affinity Capture-MS Homo sapiens
75 TUBA1A 7846
Reconstituted Complex Homo sapiens
76 UBE2I 7329
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
77 BAG6 7917
Affinity Capture-MS Homo sapiens
78 SRSF6 6431
Affinity Capture-MS Homo sapiens
79 MCM10 55388
Reconstituted Complex Homo sapiens
80 SMARCA4 6597
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
81 SERTAD1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
82 TUBA1C 84790
Reconstituted Complex Homo sapiens
83 YWHAE 7531
Affinity Capture-MS Homo sapiens
84 ACTN4 81
Reconstituted Complex Homo sapiens
85 Inpp5b  
Affinity Capture-MS Mus musculus
86 PIAS2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
87 NCL 4691
Affinity Capture-Western Homo sapiens
88 ACTB 60
Reconstituted Complex Homo sapiens
89 ARHGEF6 9459
Affinity Capture-MS Homo sapiens
90 PML 5371
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
91 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
92 EBNA-LP  
Two-hybrid
Affinity Capture-Western
93 MYL12A 10627
Reconstituted Complex Homo sapiens
94 ACTG1 71
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
95 MCM2 4171
Reconstituted Complex Homo sapiens
96 DAXX  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
97 RPL11 6135
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
98 MTR 4548
Reconstituted Complex Homo sapiens
99 PA2G4 5036
Affinity Capture-MS Homo sapiens
100 TUBB 203068
Reconstituted Complex Homo sapiens
101 LSM8 51691
Co-fractionation Homo sapiens
102 ZNF420  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
103 AK2 204
Affinity Capture-MS Homo sapiens
104 ACLY 47
Reconstituted Complex Homo sapiens
105 METTL14  
Affinity Capture-MS Homo sapiens
106 OTUD1 220213
Affinity Capture-MS Homo sapiens
107 PTEN 5728
Positive Genetic Homo sapiens
108 PANX1 24145
Proximity Label-MS Homo sapiens
109 ECT2 1894
Affinity Capture-MS Homo sapiens
110 SNRPB 6628
Reconstituted Complex Homo sapiens
111 EEF2 1938
Reconstituted Complex Homo sapiens
112 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
113 HSP90AB1 3326
Reconstituted Complex Homo sapiens
114 ACTBL2 345651
Co-fractionation Homo sapiens
115 CIT 11113
Affinity Capture-MS Homo sapiens
116 TUBB4B 10383
Reconstituted Complex Homo sapiens
117 BECN1 8678
Reconstituted Complex Homo sapiens
118 YY1 7528
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
119 MDM4  
Affinity Capture-Western Homo sapiens
120 MYO1C 4641
Affinity Capture-MS Homo sapiens
121 NXF1 10482
Affinity Capture-RNA Homo sapiens
122 AURKB 9212
Affinity Capture-MS Homo sapiens
123 MAPK6  
Affinity Capture-MS Homo sapiens
124 ARHGAP25  
Affinity Capture-MS Homo sapiens
125 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
126 TP63  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
127 TOP1 7150
Affinity Capture-Western Homo sapiens
128 KAT5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
129 CDC45  
Reconstituted Complex Homo sapiens
130 SAP25  
Affinity Capture-MS Homo sapiens
131 CCNG1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
132 ARGLU1  
Affinity Capture-MS Homo sapiens
133 CDKN2D  
Affinity Capture-MS Homo sapiens
134 CDC7  
Reconstituted Complex Homo sapiens
135 CCND1 595
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
136 PEX3 8504
Proximity Label-MS Homo sapiens
137 MMRN1 22915
Reconstituted Complex Homo sapiens
138 SUPT16H 11198
Affinity Capture-MS Homo sapiens
139 MDM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
140 GNL3 26354
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
141 HUWE1 10075
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
142 COMMD1 150684
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
143 HIF1A 3091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
144 HIPK4  
Affinity Capture-MS Homo sapiens
145 SLC4A1 6521
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
146 RELA 5970
Affinity Capture-Western Homo sapiens
147 FN1 2335
Two-hybrid Homo sapiens
148 GGA3 23163
FRET Homo sapiens
149 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
150 RRM2 6241
Negative Genetic Homo sapiens
151 CCND2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
152 Tubb5 22154
Affinity Capture-MS Mus musculus
153 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
154 NMI  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
155 FOLR1 2348
Affinity Capture-MS Homo sapiens
156 RUVBL2 10856
Reconstituted Complex Homo sapiens
157 DEAF1 10522
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
158 MCM5 4174
Reconstituted Complex Homo sapiens
159 KLHDC3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
160 KAT2B  
Affinity Capture-Western Homo sapiens
161 CDC37 11140
Affinity Capture-MS Homo sapiens
162 HNRNPA2B1 3181
Reconstituted Complex Homo sapiens
163 DGCR8  
Affinity Capture-MS Homo sapiens
164 2310003H01Rik  
Affinity Capture-MS Mus musculus
165 IMPDH1 3614
Affinity Capture-MS Homo sapiens
166 CDC6  
Reconstituted Complex Homo sapiens
167 PPP1R9B 84687
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
168 HDAC1 3065
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
169 TDRD7 23424
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
170 CDK6 1021
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
171 ERGIC1 57222
Proximity Label-MS Homo sapiens
172 ARFIP2 23647
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
173 BRK1 55845
Co-fractionation Homo sapiens
174 PCNA 5111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
175 EPHA3 2042
Reconstituted Complex Homo sapiens
176 ACTA1 58
Co-fractionation Homo sapiens
177 ING1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 MOV10 4343
Affinity Capture-RNA Homo sapiens
179 BCL2L1 598
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
180 CDK4 1019
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
181 C16orf72 29035
Affinity Capture-MS Homo sapiens
182 PRKCA 5578
Two-hybrid Homo sapiens
183 GLTSCR2  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
184 CDK5RAP3 80279
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
185 METTL3  
Affinity Capture-MS Homo sapiens
186 C1QBP 708
Affinity Capture-MS Homo sapiens
187 SERBP1 26135
Affinity Capture-MS Homo sapiens
188 HNRNPU 3192
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
189 C9orf72  
Affinity Capture-MS Homo sapiens
190 RC3H1 149041
Affinity Capture-MS Homo sapiens
191 CDKN2C  
Affinity Capture-MS Homo sapiens
192 IKBKB 3551
Affinity Capture-Western Homo sapiens
193 FKBP2 2286
Affinity Capture-Western Homo sapiens
194 RPP38 10557
Co-fractionation Homo sapiens
195 Smn1 20595
Affinity Capture-MS Mus musculus
196 CDK11A 728642
Affinity Capture-MS Homo sapiens
197 CDC5L 988
Reconstituted Complex Homo sapiens
198 Cdc26  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which CDKN2A is involved
No pathways found





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