Gene description for VRK3
Gene name vaccinia related kinase 3
Gene symbol VRK3
Other names/aliases -
Species Homo sapiens
 Database cross references - VRK3
ExoCarta ExoCarta_51231
Vesiclepedia VP_51231
Entrez Gene 51231
HGNC 18996
UniProt Q8IV63  
 VRK3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for VRK3
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein phosphatase binding GO:0019903 IDA
Biological Process
    DNA damage response GO:0006974 IBA
    signal transduction GO:0007165 IBA
    skeletal muscle tissue development GO:0007519 IGI
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified VRK3 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for VRK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
2 HNRNPC 3183
Affinity Capture-MS Homo sapiens
3 PPP1CB 5500
Affinity Capture-MS Homo sapiens
4 TWF2 11344
Affinity Capture-MS Homo sapiens
5 EEF1G 1937
Affinity Capture-MS Homo sapiens
6 RPS3A 6189
Affinity Capture-MS Homo sapiens
7 RPS17 6218
Affinity Capture-MS Homo sapiens
8 PSMA4 5685
Affinity Capture-MS Homo sapiens
9 FOXD3  
Affinity Capture-MS Homo sapiens
10 BTF3 689
Affinity Capture-MS Homo sapiens
11 TAB1 10454
Affinity Capture-MS Homo sapiens
12 RPL14 9045
Affinity Capture-MS Homo sapiens
13 HNRNPR 10236
Affinity Capture-MS Homo sapiens
14 CFL1 1072
Affinity Capture-MS Homo sapiens
15 HSPA1A 3303
Affinity Capture-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 YTHDF2 51441
Affinity Capture-MS Homo sapiens
18 ANKRD50 57182
Affinity Capture-MS Homo sapiens
19 RPS18 6222
Affinity Capture-MS Homo sapiens
20 RPS20 6224
Affinity Capture-MS Homo sapiens
21 HIST1H2BM 8342
Affinity Capture-MS Homo sapiens
22 JARID2  
Affinity Capture-MS Homo sapiens
23 SPIN1  
Affinity Capture-MS Homo sapiens
24 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 RCBTB2  
Affinity Capture-MS Homo sapiens
26 HMGA1 3159
Affinity Capture-MS Homo sapiens
27 HMGA2 8091
Affinity Capture-MS Homo sapiens
28 HSPA6 3310
Affinity Capture-MS Homo sapiens
29 CSNK2B 1460
Two-hybrid Homo sapiens
30 C11orf84  
Affinity Capture-MS Homo sapiens
31 HSPA8 3312
Affinity Capture-MS Homo sapiens
32 FOXP1 27086
Affinity Capture-MS Homo sapiens
33 ATXN2 6311
Affinity Capture-MS Homo sapiens
34 CCT2 10576
Affinity Capture-MS Homo sapiens
35 LMTK3  
Affinity Capture-MS Homo sapiens
36 PPP1CA 5499
Affinity Capture-MS Homo sapiens
37 VRK3 51231
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TCP1 6950
Affinity Capture-MS Homo sapiens
39 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 EMD 2010
Affinity Capture-MS Homo sapiens
41 RB1CC1 9821
Affinity Capture-MS Homo sapiens
42 RPS10 6204
Affinity Capture-MS Homo sapiens
43 CLNS1A 1207
Affinity Capture-MS Homo sapiens
44 CCT5 22948
Affinity Capture-MS Homo sapiens
45 CCNB1 891
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
46 RPL18A 6142
Affinity Capture-MS Homo sapiens
47 TUBA1C 84790
Affinity Capture-MS Homo sapiens
48 OGT 8473
Reconstituted Complex Homo sapiens
49 AIM2  
Affinity Capture-MS Homo sapiens
50 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
51 NR2E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SRF  
Affinity Capture-MS Homo sapiens
53 BANF1 8815
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
54 YWHAQ 10971
Affinity Capture-MS Homo sapiens
55 RPLP1 6176
Affinity Capture-MS Homo sapiens
56 SNRPD1 6632
Affinity Capture-MS Homo sapiens
57 RPS15A 6210
Affinity Capture-MS Homo sapiens
58 KCTD2  
Affinity Capture-MS Homo sapiens
59 MAP4K1  
Affinity Capture-MS Homo sapiens
60 RPL11 6135
Affinity Capture-MS Homo sapiens
61 ZNF524  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 BCLAF1 9774
Affinity Capture-MS Homo sapiens
63 TUBB 203068
Affinity Capture-MS Homo sapiens
64 RPLP2 6181
Affinity Capture-MS Homo sapiens
65 Cbx1  
Affinity Capture-MS Mus musculus
66 CTNNB1 1499
Affinity Capture-MS Homo sapiens
67 RPL21 6144
Affinity Capture-MS Homo sapiens
68 TUBB4B 10383
Affinity Capture-MS Homo sapiens
69 USP54 159195
Affinity Capture-MS Homo sapiens
70 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
71 PLK1 5347
Two-hybrid Homo sapiens
72 EMX2  
Affinity Capture-MS Homo sapiens
73 BICD2 23299
Affinity Capture-MS Homo sapiens
74 RPS14 6208
Affinity Capture-MS Homo sapiens
75 RPL12 6136
Affinity Capture-MS Homo sapiens
76 CMYA5 202333
Affinity Capture-MS Homo sapiens
77 HSPA4 3308
Affinity Capture-Western Homo sapiens
78 MOB2 81532
Affinity Capture-MS Homo sapiens
79 PARP1 142
Affinity Capture-Western Homo sapiens
80 TXNDC5 81567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 HSPD1 3329
Affinity Capture-MS Homo sapiens
82 SCAPER  
Affinity Capture-MS Homo sapiens
83 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
84 XRCC5 7520
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
85 CHD7  
Affinity Capture-MS Homo sapiens
86 DYNC2LI1 51626
Affinity Capture-MS Homo sapiens
87 RPL13 6137
Affinity Capture-MS Homo sapiens
88 DHX15 1665
Affinity Capture-MS Homo sapiens
89 MYCBP 26292
Affinity Capture-MS Homo sapiens
90 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
91 KCTD17 79734
Affinity Capture-MS Homo sapiens
92 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
93 SLC25A6 293
Affinity Capture-MS Homo sapiens
94 H3F3A 3020
Affinity Capture-MS Homo sapiens
95 MAX  
Affinity Capture-MS Homo sapiens
96 CLUAP1 23059
Affinity Capture-MS Homo sapiens
97 BLOC1S5-TXNDC5  
Affinity Capture-MS Homo sapiens
98 CDC37 11140
Affinity Capture-MS Homo sapiens
99 SCRT1 83482
Affinity Capture-MS Homo sapiens
100 HNRNPM 4670
Affinity Capture-MS Homo sapiens
101 IFI6  
Affinity Capture-MS Homo sapiens
102 IGHG2 3501
Affinity Capture-MS Homo sapiens
103 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
104 EZH1  
Affinity Capture-MS Homo sapiens
105 UQCR11  
Affinity Capture-MS Homo sapiens
106 HNRNPK 3190
Affinity Capture-MS Homo sapiens
107 SP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 CNTRL  
Affinity Capture-MS Homo sapiens
109 SNRPN 6638
Affinity Capture-MS Homo sapiens
110 RPL10A 4736
Affinity Capture-MS Homo sapiens
111 ACTA1 58
Affinity Capture-MS Homo sapiens
112 RPS24 6229
Affinity Capture-MS Homo sapiens
113 NCL 4691
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
114 ALYREF 10189
Affinity Capture-Western Homo sapiens
115 PRDX1 5052
Affinity Capture-MS Homo sapiens
116 RPS7 6201
Affinity Capture-MS Homo sapiens
117 XRCC6 2547
Affinity Capture-MS Homo sapiens
118 RPL23A 6147
Affinity Capture-MS Homo sapiens
119 HNRNPU 3192
Affinity Capture-MS Homo sapiens
120 VIM 7431
Affinity Capture-MS Homo sapiens
121 PCYT1A 5130
Affinity Capture-MS Homo sapiens
122 C16orf87 388272
Affinity Capture-MS Homo sapiens
123 EEF2 1938
Affinity Capture-MS Homo sapiens
124 RPL17 6139
Affinity Capture-MS Homo sapiens
125 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
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