Gene description for ITPA
Gene name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Gene symbol ITPA
Other names/aliases C20orf37
HLC14-06-P
My049
dJ794I6.3
Species Homo sapiens
 Database cross references - ITPA
ExoCarta ExoCarta_3704
Entrez Gene 3704
HGNC 6176
MIM 147520
UniProt Q9BY32  
 ITPA identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ITPA
Molecular Function
    XTP diphosphatase activity GO:0036222 EXP
    dITP diphosphatase activity GO:0035870 EXP
    nucleotide binding GO:0000166 IEA
    ITP diphosphatase activity GO:0036220 EXP
    metal ion binding GO:0046872 IEA
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    chromosome organization GO:0051276 IEA
    small molecule metabolic process GO:0044281 TAS
    ITP catabolic process GO:0006193 IEA
    deoxyribonucleoside triphosphate catabolic process GO:0009204 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified ITPA in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITPA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ITPA is involved
PathwayEvidenceSource
Metabolism of nucleotides TAS Reactome





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