Gene description for CSF2
Gene name colony stimulating factor 2 (granulocyte-macrophage)
Gene symbol CSF2
Other names/aliases GMCSF
Species Homo sapiens
 Database cross references - CSF2
ExoCarta ExoCarta_1437
Entrez Gene 1437
HGNC 2434
MIM 138960
UniProt P04141  
 CSF2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CSF2
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    cytokine activity GO:0005125 IEA
    granulocyte macrophage colony-stimulating factor receptor binding GO:0005129 IEA
Biological Process
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IDA
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA
    positive regulation of cell proliferation GO:0008284 IEA
    positive regulation of podosome assembly GO:0071803 IDA
    embryonic placenta development GO:0001892 IEA
    positive regulation of DNA replication GO:0045740 IDA
    epithelial fluid transport GO:0042045 IEA
    myeloid dendritic cell differentiation GO:0043011 IEA
    dendritic cell differentiation GO:0097028 IDA
    positive regulation of macrophage derived foam cell differentiation GO:0010744 IDA
    immune response GO:0006955 IEA
    macrophage activation GO:0042116 IEA
    positive regulation of gene expression GO:0010628 IDA
    cellular response to lipopolysaccharide GO:0071222 IEA
    positive regulation of interleukin-23 production GO:0032747 IDA
    negative regulation of cytolysis GO:0045918 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CSF2 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CSF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SDC2 6383
Reconstituted Complex Homo sapiens
2 CSF2RB  
Invivo Homo sapiens
Invitro Homo sapiens
3 PRG2  
Invitro Homo sapiens
4 CSF2RA  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
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