Gene description for CERS1
Gene name ceramide synthase 1
Gene symbol CERS1
Other names/aliases EPM8
LAG1
LASS1
UOG1
Species Homo sapiens
 Database cross references - CERS1
ExoCarta ExoCarta_10715
Entrez Gene 10715
HGNC 14253
MIM 606919
UniProt P27544  
 CERS1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CERS1
Molecular Function
    sphingosine N-acyltransferase activity GO:0050291 ISS
    molecular_function GO:0003674 ND
Biological Process
    cellular response to dithiothreitol GO:0072721 IDA
    negative regulation of telomerase activity GO:0051974 IDA
    sphingolipid metabolic process GO:0006665 TAS
    small molecule metabolic process GO:0044281 TAS
    cellular response to UV-A GO:0071492 IDA
    cellular response to mycotoxin GO:0036146 IDA
    ceramide biosynthetic process GO:0046513 ISS
    cellular response to drug GO:0035690 IDA
    sphingolipid biosynthetic process GO:0030148 TAS
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISS
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified CERS1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CERS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CERS1 is involved
PathwayEvidenceSource
Sphingolipid de novo biosynthesis TAS Reactome





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