Gene description for TMEM214
Gene name transmembrane protein 214
Gene symbol TMEM214
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM214
ExoCarta ExoCarta_54867
Vesiclepedia VP_54867
Entrez Gene 54867
HGNC 25983
MIM 615301
UniProt Q6NUQ4  
 TMEM214 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TMEM214
Biological Process
    apoptotic process GO:0006915 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    cytoplasmic microtubule GO:0005881 IDA
 Experiment description of studies that identified TMEM214 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TMEM214
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 BRDT  
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 Rcc1  
Affinity Capture-MS Mus musculus
8 KPNB1 3837
Affinity Capture-MS Homo sapiens
9 GPC1 2817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ARSE 415
Affinity Capture-MS Homo sapiens
11 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ADPGK 83440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 STS 412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GJD3  
Proximity Label-MS Homo sapiens
15 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RET 5979
Affinity Capture-MS Homo sapiens
17 PTPN1 5770
Proximity Label-MS Homo sapiens
18 STX4 6810
Proximity Label-MS Homo sapiens
19 TLR1 7096
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KIR3DL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TMEM179B 374395
Affinity Capture-MS Homo sapiens
22 C9orf78 51759
Affinity Capture-MS Homo sapiens
23 BTN2A1 11120
Affinity Capture-MS Homo sapiens
24 RPRM  
Affinity Capture-MS Homo sapiens
25 NUP153 9972
Affinity Capture-MS Homo sapiens
26 SSR1 6745
Proximity Label-MS Homo sapiens
27 TTYH1  
Affinity Capture-MS Homo sapiens
28 ITFG3 83986
Affinity Capture-MS Homo sapiens
29 SLC25A46 91137
Proximity Label-MS Homo sapiens
30 LRRC17 10234
Affinity Capture-MS Homo sapiens
31 LSM1 27257
Two-hybrid Homo sapiens
32 CD8B 926
Affinity Capture-MS Homo sapiens
33 NUP155 9631
Proximity Label-MS Homo sapiens
34 KIAA1715 80856
Proximity Label-MS Homo sapiens
35 PXMP2  
Proximity Label-MS Homo sapiens
36 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 DNAJC5 80331
Affinity Capture-MS Homo sapiens
39 C12orf49  
Affinity Capture-MS Homo sapiens
40 C16orf58 64755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CCDC107  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 LYPD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TNFRSF10C  
Affinity Capture-MS Homo sapiens
44 RPN1 6184
Proximity Label-MS Homo sapiens
45 UPK1A 11045
Affinity Capture-MS Homo sapiens
46 Ube2i  
Affinity Capture-MS Mus musculus
47 ELOVL5 60481
Proximity Label-MS Homo sapiens
48 TTC25  
Affinity Capture-MS Homo sapiens
49 SEC61B 10952
Proximity Label-MS Homo sapiens
50 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
51 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RMDN3 55177
Proximity Label-MS Homo sapiens
53 SEC63 11231
Proximity Label-MS Homo sapiens
54 ZC4H2 55906
Affinity Capture-MS Homo sapiens
55 EFNA4  
Affinity Capture-MS Homo sapiens
56 NHLRC3 387921
Affinity Capture-MS Homo sapiens
57 RPN2 6185
Proximity Label-MS Homo sapiens
58 Nup98  
Affinity Capture-MS Mus musculus
59 LRRC59 55379
Proximity Label-MS Homo sapiens
60 LMNB1 4001
Proximity Label-MS Homo sapiens
61 ZBTB24  
Affinity Capture-MS Homo sapiens
62 HMOX2 3163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BRD2  
Affinity Capture-MS Homo sapiens
64 HS3ST2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CRELD1 78987
Affinity Capture-MS Homo sapiens
66 BCAP31 10134
Proximity Label-MS Homo sapiens
67 HSD3B7 80270
Proximity Label-MS Homo sapiens
68 NR3C1 2908
Affinity Capture-MS Homo sapiens
69 STIM1 6786
Proximity Label-MS Homo sapiens
70 TMEM258  
Affinity Capture-MS Homo sapiens
71 FKBP8 23770
Proximity Label-MS Homo sapiens
72 RBM18  
Affinity Capture-MS Homo sapiens
73 NUP43 348995
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
74 FBXO6 26270
Affinity Capture-MS Homo sapiens
75 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CD27  
Affinity Capture-MS Homo sapiens
77 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PTPRN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 C1orf210  
Affinity Capture-MS Homo sapiens
80 Nup107  
Affinity Capture-MS Mus musculus
81 RPA3 6119
Proximity Label-MS Homo sapiens
82 ATP2A1 487
Proximity Label-MS Homo sapiens
83 NCLN 56926
Affinity Capture-MS Homo sapiens
84 TLR2 7097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TGFA  
Affinity Capture-MS Homo sapiens
86 OPCML  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 DPM2 8818
Affinity Capture-MS Homo sapiens
88 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 SEH1L 81929
Affinity Capture-MS Homo sapiens
90 TMPRSS5  
Affinity Capture-MS Homo sapiens
91 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
92 TLR10  
Affinity Capture-MS Homo sapiens
93 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
94 KCNA2  
Affinity Capture-MS Homo sapiens
95 SEMA7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
97 LDLRAD1  
Affinity Capture-MS Homo sapiens
98 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 NUP35 129401
Proximity Label-MS Homo sapiens
100 MKI67  
Affinity Capture-MS Homo sapiens
101 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 NUP107 57122
Affinity Capture-MS Homo sapiens
103 ARSG 22901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 SEC62 7095
Proximity Label-MS Homo sapiens
105 RAB7A 7879
Proximity Label-MS Homo sapiens
106 CIT 11113
Affinity Capture-MS Homo sapiens
107 Ranbp2  
Affinity Capture-MS Mus musculus
108 DNAJC1 64215
Proximity Label-MS Homo sapiens
109 CCDC47 57003
Affinity Capture-MS Homo sapiens
110 CKAP4 10970
Proximity Label-MS Homo sapiens
111 SPINT2 10653
Affinity Capture-MS Homo sapiens
112 CLEC4E  
Affinity Capture-MS Homo sapiens
113 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM214 is involved
No pathways found





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