Gene description for TRIP11
Gene name thyroid hormone receptor interactor 11
Gene symbol TRIP11
Other names/aliases ACG1A
CEV14
GMAP-210
GMAP210
TRIP-11
TRIP230
Species Homo sapiens
 Database cross references - TRIP11
ExoCarta ExoCarta_9321
Vesiclepedia VP_9321
Entrez Gene 9321
HGNC 12305
MIM 604505
UniProt Q15643  
 TRIP11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TRIP11
Molecular Function
    transcription coactivator activity GO:0003713 TAS
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
Biological Process
    ventricular septum development GO:0003281 IEA
    chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 IEA
    transcription by RNA polymerase II GO:0006366 TAS
    protein glycosylation GO:0006486 IEA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    Golgi organization GO:0007030 IBA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    cartilage development GO:0051216 IMP
    inner ear receptor cell stereocilium organization GO:0060122 IEA
    protein transmembrane transport GO:0071806 IEA
    Golgi ribbon formation GO:0090161 IMP
    vesicle tethering to Golgi GO:0099041 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    inner acrosomal membrane GO:0002079 IEA
    outer acrosomal membrane GO:0002081 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cis-Golgi network GO:0005801 IEA
    cytoskeleton GO:0005856 IEA
    transport vesicle GO:0030133 TAS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
 Experiment description of studies that identified TRIP11 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
6
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TRIP11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 HOOK1  
Affinity Capture-MS Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 YWHAE 7531
Affinity Capture-MS Homo sapiens
9 ARF3 377
Proximity Label-MS Homo sapiens
10 KIF20A 10112
Affinity Capture-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 STX4 6810
Proximity Label-MS Homo sapiens
13 B3GAT1  
Proximity Label-MS Homo sapiens
14 PCNT  
Proximity Label-MS Homo sapiens
15 MLLT4 4301
Proximity Label-MS Homo sapiens
16 USO1 8615
Affinity Capture-MS Homo sapiens
17 RAB3B 5865
Proximity Label-MS Homo sapiens
18 NUP35 129401
Proximity Label-MS Homo sapiens
19 Thrb  
Two-hybrid Rattus norvegicus
20 YWHAG 7532
Affinity Capture-MS Homo sapiens
21 PIGH  
Affinity Capture-MS Homo sapiens
22 STX6 10228
Proximity Label-MS Homo sapiens
23 SLC25A46 91137
Proximity Label-MS Homo sapiens
24 YWHAH 7533
Affinity Capture-MS Homo sapiens
25 ATG16L1 55054
Affinity Capture-MS Homo sapiens
26 Haus1  
Affinity Capture-MS Mus musculus
27 GORASP1 64689
Proximity Label-MS Homo sapiens
28 EBAG9 9166
Proximity Label-MS Homo sapiens
29 Dctn1 13191
Affinity Capture-MS Mus musculus
30 EXOC3 11336
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MED4 29079
Affinity Capture-MS Homo sapiens
32 NCOA1  
Affinity Capture-MS Homo sapiens
33 YWHAB 7529
Affinity Capture-MS Homo sapiens
34 NUP155 9631
Proximity Label-MS Homo sapiens
35 RB1 5925
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 KRT8 3856
Proximity Label-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 CXADR 1525
Proximity Label-MS Homo sapiens
39 BACH1 571
Affinity Capture-MS Homo sapiens
40 RAB4A 5867
Proximity Label-MS Homo sapiens
41 CDH1 999
Proximity Label-MS Homo sapiens
42 Sidt2  
Affinity Capture-MS Mus musculus
43 ARNT 405
Reconstituted Complex Homo sapiens
44 STIL  
Proximity Label-MS Homo sapiens
45 ELOVL5 60481
Proximity Label-MS Homo sapiens
46 BDH2 56898
Affinity Capture-MS Homo sapiens
47 DISC1 27185
Affinity Capture-MS Homo sapiens
48 CHPF 79586
Affinity Capture-MS Homo sapiens
49 COPS2 9318
Affinity Capture-MS Homo sapiens
50 RAB7A 7879
Proximity Label-MS Homo sapiens
51 RAB5A 5868
Proximity Label-MS Homo sapiens
52 LAMP1 3916
Proximity Label-MS Homo sapiens
53 HSD3B7 80270
Proximity Label-MS Homo sapiens
54 NR3C1 2908
Proximity Label-MS Homo sapiens
55 BFSP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 KXD1 79036
Affinity Capture-MS Homo sapiens
57 PFN1 5216
Proximity Label-MS Homo sapiens
58 DUSP16  
Affinity Capture-MS Homo sapiens
59 SASS6 163786
Proximity Label-MS Homo sapiens
60 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
61 THRA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
62 RAB9A 9367
Proximity Label-MS Homo sapiens
63 PSMC5 5705
Two-hybrid Homo sapiens
64 ZRANB1 54764
Affinity Capture-MS Homo sapiens
65 GOLGA2 2801
Proximity Label-MS Homo sapiens
66 RNF43  
Proximity Label-MS Homo sapiens
67 LAMTOR1 55004
Proximity Label-MS Homo sapiens
68 ATXN1L  
Two-hybrid Homo sapiens
69 ARF5 381
Proximity Label-MS Homo sapiens
70 LCK 3932
Proximity Label-MS Homo sapiens
71 SEPT10 151011
Proximity Label-MS Homo sapiens
72 C15orf59  
Affinity Capture-MS Homo sapiens
73 ERGIC1 57222
Proximity Label-MS Homo sapiens
74 ARF4 378
Proximity Label-MS Homo sapiens
75 LATS1  
Proximity Label-MS Homo sapiens
76 BRK1 55845
Affinity Capture-MS Homo sapiens
77 Tuba3a 22144
Affinity Capture-MS Mus musculus
78 PXMP2  
Proximity Label-MS Homo sapiens
79 ERGIC2 51290
Proximity Label-MS Homo sapiens
80 RAB2A 5862
Proximity Label-MS Homo sapiens
81 ASB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PXN 5829
Proximity Label-MS Homo sapiens
83 RAB11A 8766
Proximity Label-MS Homo sapiens
84 ARF1 375
Proximity Label-MS Homo sapiens
85 EPHA2 1969
Proximity Label-MS Homo sapiens
86 RAB5C 5878
Proximity Label-MS Homo sapiens
87 CCT8L2  
Affinity Capture-MS Homo sapiens
88 CAV1 857
Proximity Label-MS Homo sapiens
89 MYH6 4624
Affinity Capture-MS Homo sapiens
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