Gene description for TRIP11
Gene name thyroid hormone receptor interactor 11
Gene symbol TRIP11
Other names/aliases ACG1A
Species Homo sapiens
 Database cross references - TRIP11
ExoCarta ExoCarta_9321
Entrez Gene 9321
HGNC 12305
MIM 604505
UniProt Q15643  
 TRIP11 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for TRIP11
Molecular Function
    transcription coactivator activity GO:0003713 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of nucleic acid-templated transcription GO:1903506 TAS
    ventricular septum development GO:0003281 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    organelle organization GO:0006996 TAS
    protein targeting to Golgi GO:0000042 IEA
Subcellular Localization
    outer acrosomal membrane GO:0002081 IEA
    Golgi membrane GO:0000139 TAS
    cis-Golgi network GO:0005801 IEA
    inner acrosomal membrane GO:0002079 IEA
    nucleus GO:0005634 IDA
    Golgi apparatus GO:0005794 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified TRIP11 in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for TRIP11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 Thrb  
Two-hybrid Rattus norvegicus
View the network image/svg+xml
 Pathways in which TRIP11 is involved
Intraflagellar transport TAS Reactome

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