Gene description for ITPR1
Gene name inositol 1,4,5-trisphosphate receptor, type 1
Gene symbol ITPR1
Other names/aliases ACV
CLA4
INSP3R1
IP3R
IP3R1
PPP1R94
SCA15
SCA16
SCA29
Species Homo sapiens
 Database cross references - ITPR1
ExoCarta ExoCarta_3708
Vesiclepedia VP_3708
Entrez Gene 3708
HGNC 6180
MIM 147265
UniProt Q14643  
 ITPR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ITPR1
Molecular Function
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 IBA
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 IDA
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 IMP
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 ISS
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 TAS
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    calcium ion transmembrane transporter activity GO:0015085 TAS
    intracellularly gated calcium channel activity GO:0015278 ISS
    calcium channel inhibitor activity GO:0019855 IDA
    protein domain specific binding GO:0019904 IEA
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 ISS
    protein homodimerization activity GO:0042803 IEA
    inositol 1,4,5 trisphosphate binding GO:0070679 IBA
    inositol 1,4,5 trisphosphate binding GO:0070679 ISS
    inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels GO:0098695 IEA
Biological Process
    cell morphogenesis GO:0000902 IEA
    response to hypoxia GO:0001666 IDA
    calcium ion transport GO:0006816 NAS
    signal transduction GO:0007165 NAS
    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207 IEA
    single fertilization GO:0007338 ISS
    post-embryonic development GO:0009791 IEA
    regulation of autophagy GO:0010506 TAS
    calcium-mediated signaling GO:0019722 IEA
    positive regulation of insulin secretion GO:0032024 IEA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IEA
    calcium import into the mitochondrion GO:0036444 ISS
    epithelial fluid transport GO:0042045 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of calcium-mediated signaling GO:0050849 IDA
    voluntary musculoskeletal movement GO:0050882 IEA
    release of sequestered calcium ion into cytosol GO:0051209 IBA
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    protein homotetramerization GO:0051289 ISS
    regulation of cytosolic calcium ion concentration GO:0051480 ISS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    ion channel modulating, G protein-coupled receptor signaling pathway GO:0099105 IEA
    regulation of postsynaptic cytosolic calcium ion concentration GO:0099566 IEA
    release of sequestered calcium ion into cytosol by endoplasmic reticulum GO:1903514 IDA
    ligand-gated ion channel signaling pathway GO:1990806 IEA
Subcellular Localization
    nuclear inner membrane GO:0005637 IEA
    nucleolus GO:0005730 IEA
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum GO:0005783 NAS
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IBA
    calcineurin complex GO:0005955 IEA
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 HDA
    sarcoplasmic reticulum GO:0016529 IBA
    transport vesicle membrane GO:0030658 IEA
    secretory granule membrane GO:0030667 IBA
    platelet dense granule membrane GO:0031088 IDA
    platelet dense tubular network GO:0031094 IDA
    platelet dense tubular network membrane GO:0031095 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
 Experiment description of studies that identified ITPR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ITPR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF170 81790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 CABP2  
Affinity Capture-MS Homo sapiens
4 Fus  
Affinity Capture-MS Mus musculus
5 PRKCD 5580
Reconstituted Complex Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 BTF3 689
Affinity Capture-MS Homo sapiens
8 CTDNEP1 23399
Proximity Label-MS Homo sapiens
9 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
FRET Homo sapiens
10 KIF20A 10112
Affinity Capture-MS Homo sapiens
11 HSD17B11 51170
Proximity Label-MS Homo sapiens
12 DNAJC25 548645
Proximity Label-MS Homo sapiens
13 CALM1 801
Affinity Capture-Western Homo sapiens
14 UFD1L 7353
Affinity Capture-Western Homo sapiens
15 ITPR3 3710
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 CA8  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
19 AMFR 267
Affinity Capture-Western Homo sapiens
20 BBOX1 8424
Affinity Capture-MS Homo sapiens
21 CALD1 800
Affinity Capture-MS Homo sapiens
22 SSR1 6745
Proximity Label-MS Homo sapiens
23 RHOA 387
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
24 RPN2 6185
Proximity Label-MS Homo sapiens
25 DNAJC16  
Proximity Label-MS Homo sapiens
26 TESPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATG16L1 55054
Affinity Capture-MS Homo sapiens
28 Homer2  
Reconstituted Complex Rattus norvegicus
29 Lima1  
Affinity Capture-MS Mus musculus
30 KIF14 9928
Affinity Capture-MS Homo sapiens
31 AKT1 207
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
32 NUP155 9631
Proximity Label-MS Homo sapiens
33 KIAA1715 80856
Proximity Label-MS Homo sapiens
34 PXMP2  
Proximity Label-MS Homo sapiens
35 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 POLD1 5424
Affinity Capture-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 CTDP1 9150
Affinity Capture-MS Homo sapiens
39 TRPC4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
40 CALML3 810
Affinity Capture-MS Homo sapiens
41 PLK2  
Affinity Capture-MS Homo sapiens
42 TRPC2  
Affinity Capture-Western Homo sapiens
43 TRPC1  
Affinity Capture-Western Homo sapiens
44 CHMP4B 128866
Affinity Capture-MS Homo sapiens
45 PSMD2 5708
Affinity Capture-Western Homo sapiens
46 VCP 7415
Affinity Capture-Western Homo sapiens
47 RASEF  
Affinity Capture-MS Homo sapiens
48 CABP1 9478
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
49 FANCD2  
Affinity Capture-MS Homo sapiens
50 CCDC101  
Affinity Capture-MS Homo sapiens
51 ELOVL5 60481
Proximity Label-MS Homo sapiens
52 SEC61B 10952
Proximity Label-MS Homo sapiens
53 ANLN 54443
Affinity Capture-MS Homo sapiens
54 EPB41L1 2036
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
55 HSD3B7 80270
Proximity Label-MS Homo sapiens
56 Myh9 17886
Affinity Capture-MS Mus musculus
57 CANX 821
Affinity Capture-MS Homo sapiens
58 AHCYL1 10768
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
59 ECT2 1894
Affinity Capture-MS Homo sapiens
60 BCAP31 10134
Proximity Label-MS Homo sapiens
61 RAB29 8934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 FKBP8 23770
Proximity Label-MS Homo sapiens
63 Top2b 21974
Affinity Capture-MS Mus musculus
64 PRKACA 5566
Proximity Label-MS Homo sapiens
65 SYNPO 11346
Affinity Capture-MS Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 ATP2A1 487
Proximity Label-MS Homo sapiens
68 RPN1 6184
Proximity Label-MS Homo sapiens
69 Kctd5  
Affinity Capture-MS Mus musculus
70 TRPC6 7225
Affinity Capture-Western Homo sapiens
71 BANK1  
Affinity Capture-Western Homo sapiens
72 Mad2l1 56150
Affinity Capture-MS Mus musculus
73 SDC2 6383
Affinity Capture-Western Homo sapiens
74 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
75 STARD13 90627
Two-hybrid Homo sapiens
76 SIRT6  
Affinity Capture-MS Homo sapiens
77 ERLIN1 10613
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 TRPC5  
Affinity Capture-Western Homo sapiens
79 Myo1c 17913
Affinity Capture-MS Mus musculus
80 FBXL14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 CAPZA2 830
Affinity Capture-MS Homo sapiens
82 TRPC3  
Affinity Capture-Western Homo sapiens
83 ERLIN2 11160
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
84 GTF2H5  
Affinity Capture-MS Homo sapiens
85 FKBP1A 2280
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
86 MAGEA9  
Affinity Capture-MS Homo sapiens
87 Myh10 77579
Affinity Capture-MS Mus musculus
88 FGL2 10875
Affinity Capture-MS Homo sapiens
89 BCL2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 SEC62 7095
Proximity Label-MS Homo sapiens
91 RAB7A 7879
Proximity Label-MS Homo sapiens
92 Homer1  
Reconstituted Complex Rattus norvegicus
93 ITPR1 3708
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 DNAJC1 64215
Proximity Label-MS Homo sapiens
95 PRKG1 5592
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 DERL1 79139
Proximity Label-MS Homo sapiens
97 MRVI1 10335
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ITPR1 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Adaptive Immune System TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Beta-catenin independent WNT signaling IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
Ca2+ pathway IEA Reactome
Cardiac conduction IEA Reactome
Cardiac conduction TAS Reactome
cGMP effects TAS Reactome
CLEC7A (Dectin-1) induces NFAT activation IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
DAG and IP3 signaling IEA Reactome
Disease IEA Reactome
Effects of PIP2 hydrolysis TAS Reactome
Elevation of cytosolic Ca2+ levels TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR3A-mediated IL10 synthesis IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events TAS Reactome
G-protein mediated events IEA Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion TAS Reactome
GPCR downstream signalling IEA Reactome
GPCR downstream signalling TAS Reactome
Hemostasis TAS Reactome
Immune System IEA Reactome
Immune System TAS Reactome
Infectious disease IEA Reactome
Innate Immune System IEA Reactome
Integration of energy metabolism IEA Reactome
Integration of energy metabolism TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Ion homeostasis IEA Reactome
Ion homeostasis TAS Reactome
Leishmania infection IEA Reactome
Leishmania parasite growth and survival IEA Reactome
Metabolism IEA Reactome
Metabolism TAS Reactome
Muscle contraction IEA Reactome
Muscle contraction TAS Reactome
Nitric oxide stimulates guanylate cyclase TAS Reactome
Opioid Signalling IEA Reactome
Parasitic Infection Pathways IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet calcium homeostasis TAS Reactome
Platelet homeostasis TAS Reactome
PLC beta mediated events IEA Reactome
Regulation of insulin secretion IEA Reactome
Regulation of insulin secretion TAS Reactome
Role of phospholipids in phagocytosis IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by GPCR TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by VEGF IEA Reactome
Signaling by WNT IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated cell proliferation IEA Reactome





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