Gene description for ITPR2
Gene name inositol 1,4,5-trisphosphate receptor, type 2
Gene symbol ITPR2
Other names/aliases ANHD
CFAP48
INSP3R2
IP3R2
Species Homo sapiens
 Database cross references - ITPR2
ExoCarta ExoCarta_3709
Entrez Gene 3709
HGNC 6181
MIM 600144
UniProt Q14571  
 ITPR2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Mesenchymal stem cells Unpublished / Not applicable
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for ITPR2
Molecular Function
    calcium ion transmembrane transporter activity GO:0015085 TAS
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0005220 IEA
    phosphatidylinositol binding GO:0035091 IEA
Biological Process
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    regulation of insulin secretion GO:0050796 TAS
    blood coagulation GO:0007596 TAS
    calcium ion transmembrane transport GO:0070588 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    signal transduction GO:0007165 TAS
    small molecule metabolic process GO:0044281 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    cellular response to cAMP GO:0071320 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    innate immune response GO:0045087 TAS
    transport GO:0006810 TAS
    energy reserve metabolic process GO:0006112 TAS
    cellular response to ethanol GO:0071361 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    activation of phospholipase C activity GO:0007202 TAS
    response to hypoxia GO:0001666 IDA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    platelet activation GO:0030168 TAS
    inositol phosphate-mediated signaling GO:0048016 TAS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IDA
    receptor complex GO:0043235 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    integral component of membrane GO:0016021 IEA
    platelet dense tubular network membrane GO:0031095 TAS
    cell cortex GO:0005938 IEA
    sarcoplasmic reticulum membrane GO:0033017 IMP
 Experiment description of studies that identified ITPR2 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
3
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITPR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRPC4  
Two-hybrid Homo sapiens
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