Gene description for TSPAN17
Gene name tetraspanin 17
Gene symbol TSPAN17
Other names/aliases FBX23
FBXO23
TM4SF17
Species Homo sapiens
 Database cross references - TSPAN17
ExoCarta ExoCarta_26262
Vesiclepedia VP_26262
Entrez Gene 26262
HGNC 13594
UniProt Q96FV3  
 TSPAN17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSPAN17
Molecular Function
    enzyme binding GO:0019899 IPI
Biological Process
    regulation of membrane protein ectodomain proteolysis GO:0051043 IDA
    establishment of protein localization to organelle GO:0072594 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified TSPAN17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSPAN17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADAM10 102
Affinity Capture-Western Homo sapiens
2 BMPR1A 657
Affinity Capture-MS Homo sapiens
3 PTPRF 5792
Affinity Capture-MS Homo sapiens
4 F2RL1  
Affinity Capture-MS Homo sapiens
5 HACD3 51495
Affinity Capture-MS Homo sapiens
6 ADCY3 109
Affinity Capture-MS Homo sapiens
7 CCDC115 84317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FAM189B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 BSCL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CNNM3 26505
Affinity Capture-MS Homo sapiens
11 DDR1 780
Affinity Capture-MS Homo sapiens
12 TM2D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 AGPAT4 56895
Affinity Capture-MS Homo sapiens
17 TMEM87A 25963
Affinity Capture-MS Homo sapiens
18 METTL7A 25840
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GNB4 59345
Affinity Capture-MS Homo sapiens
20 AGPAT9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DHRS7 51635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM63B 55362
Affinity Capture-MS Homo sapiens
23 GJA1 2697
Affinity Capture-MS Homo sapiens
24 GPM6A 2823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SLC44A1 23446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KIAA2013 90231
Affinity Capture-MS Homo sapiens
27 RNF130  
Affinity Capture-MS Homo sapiens
28 TMUB1  
Affinity Capture-MS Homo sapiens
29 SLC12A7 10723
Affinity Capture-MS Homo sapiens
30 CYP51A1 1595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HS2ST1 9653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 EPHX1 2052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GHDC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PIGU 128869
Affinity Capture-MS Homo sapiens
36 TBL2 26608
Affinity Capture-MS Homo sapiens
37 AGPAT3 56894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SGCB 6443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 LRP10 26020
Affinity Capture-MS Homo sapiens
40 FLCN 201163
Affinity Capture-Western Homo sapiens
41 AGPAT6 137964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SLC38A10 124565
Affinity Capture-MS Homo sapiens
43 KDSR 2531
Affinity Capture-MS Homo sapiens
44 SLC27A6  
Affinity Capture-MS Homo sapiens
45 UBAC2 337867
Affinity Capture-MS Homo sapiens
46 RETSAT 54884
Affinity Capture-MS Homo sapiens
47 ACVR1B 91
Affinity Capture-MS Homo sapiens
48 MOV10 4343
Affinity Capture-RNA Homo sapiens
49 GP1BB 2812
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TMEM181 57583
Affinity Capture-MS Homo sapiens
51 TMEM199  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 KCNJ8  
Affinity Capture-MS Homo sapiens
53 SLC27A3 11000
Affinity Capture-MS Homo sapiens
54 KCNN4 3783
Affinity Capture-MS Homo sapiens
55 DGKE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 VRK2 7444
Affinity Capture-MS Homo sapiens
57 MPZL2 10205
Affinity Capture-MS Homo sapiens
58 PNPLA6 10908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PRAF2 11230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 AGPAT2  
Affinity Capture-MS Homo sapiens
61 PCNXL3 399909
Affinity Capture-MS Homo sapiens
62 THEM6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ATP2A3 489
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 SC5D 6309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
67 MGST3 4259
Affinity Capture-MS Homo sapiens
68 FAM210B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSPAN17 is involved
No pathways found





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