Gene description for NUPL2
Gene name nucleoporin like 2
Gene symbol NUPL2
Other names/aliases CG1
NLP-1
NLP_1
hCG1
Species Homo sapiens
 Database cross references - NUPL2
ExoCarta ExoCarta_11097
Vesiclepedia VP_11097
Entrez Gene 11097
HGNC 17010
UniProt O15504  
 NUPL2 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for NUPL2
Molecular Function
    RNA binding GO:0003723 HDA
    nuclear export signal receptor activity GO:0005049 IBA
    nuclear export signal receptor activity GO:0005049 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    protein export from nucleus GO:0006611 IGI
    nucleocytoplasmic transport GO:0006913 NAS
    mRNA transport GO:0051028 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 IDA
    nuclear pore GO:0005643 NAS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified NUPL2 in exosomes
1
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUPL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 CELF1 10658
Affinity Capture-MS Homo sapiens
4 RPUSD4 84881
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 RPL26L1 51121
Affinity Capture-MS Homo sapiens
7 NCBP1 4686
Affinity Capture-MS Homo sapiens
8 ARHGEF19  
Affinity Capture-MS Homo sapiens
9 FAM111B 374393
Affinity Capture-MS Homo sapiens
10 METTL7A 25840
Proximity Label-MS Homo sapiens
11 Nxf1  
Affinity Capture-Western Mus musculus
12 RBMS2 5939
Affinity Capture-MS Homo sapiens
13 Nxf2  
Affinity Capture-Western Mus musculus
14 KPNB1 3837
Affinity Capture-MS Homo sapiens
15 ZC3H14  
Affinity Capture-MS Homo sapiens
16 APC  
Two-hybrid Homo sapiens
17 LARP1B 55132
Affinity Capture-MS Homo sapiens
18 NGRN  
Affinity Capture-MS Homo sapiens
19 NUPL1 9818
Affinity Capture-MS Homo sapiens
20 HSD17B11 51170
Proximity Label-MS Homo sapiens
21 PUM2 23369
Affinity Capture-MS Homo sapiens
22 CCDC9  
Affinity Capture-MS Homo sapiens
23 AQR 9716
Affinity Capture-MS Homo sapiens
24 SNRPF 6636
Affinity Capture-MS Homo sapiens
25 FAM20B 9917
Affinity Capture-MS Homo sapiens
26 MRPS5 64969
Affinity Capture-MS Homo sapiens
27 RPS20 6224
Proximity Label-MS Homo sapiens
28 MARK2 2011
Affinity Capture-MS Homo sapiens
29 CRNKL1 51340
Affinity Capture-MS Homo sapiens
30 HELZ 9931
Affinity Capture-MS Homo sapiens
31 PABPC4L 132430
Affinity Capture-MS Homo sapiens
32 ISY1 57461
Affinity Capture-MS Homo sapiens
33 NUP153 9972
Affinity Capture-MS Homo sapiens
34 COPS5 10987
Affinity Capture-MS Homo sapiens
35 YARS2  
Affinity Capture-MS Homo sapiens
36 SSR1 6745
Proximity Label-MS Homo sapiens
37 PTCD1 26024
Affinity Capture-MS Homo sapiens
38 STAU2 27067
Affinity Capture-MS Homo sapiens
39 PRKRA 8575
Affinity Capture-MS Homo sapiens
40 NXT1  
Affinity Capture-MS Homo sapiens
41 MYCN  
Affinity Capture-MS Homo sapiens
42 FASTKD2  
Affinity Capture-MS Homo sapiens
43 FAM120A 23196
Affinity Capture-MS Homo sapiens
44 MTERF3  
Affinity Capture-MS Homo sapiens
45 CLK3  
Affinity Capture-MS Homo sapiens
46 ATXN2 6311
Affinity Capture-MS Homo sapiens
47 NUP155 9631
Proximity Label-MS Homo sapiens
48 MRPL13  
Affinity Capture-MS Homo sapiens
49 CLK2 1196
Affinity Capture-MS Homo sapiens
50 KRT34  
Two-hybrid Homo sapiens
51 EMD 2010
Proximity Label-MS Homo sapiens
52 C17orf85  
Affinity Capture-MS Homo sapiens
53 MAPRE1 22919
Affinity Capture-MS Homo sapiens
54 ZCCHC3  
Affinity Capture-MS Homo sapiens
55 PUM1 9698
Affinity Capture-MS Homo sapiens
56 MKRN2 23609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CNOT1 23019
Affinity Capture-MS Homo sapiens
58 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 RAN 5901
Affinity Capture-MS Homo sapiens
60 BCL2L2 599
Affinity Capture-MS Homo sapiens
61 DTX2 113878
Proximity Label-MS Homo sapiens
62 MOV10 4343
Affinity Capture-MS Homo sapiens
63 TRIM11  
Affinity Capture-MS Homo sapiens
64 PABPN1 8106
Affinity Capture-MS Homo sapiens
65 TRUB2  
Affinity Capture-MS Homo sapiens
66 IL17B 27190
Affinity Capture-MS Homo sapiens
67 RPLP0 6175
Affinity Capture-MS Homo sapiens
68 Ube2i  
Affinity Capture-MS Mus musculus
69 NKTR  
Affinity Capture-MS Homo sapiens
70 MRPL45 84311
Affinity Capture-MS Homo sapiens
71 SEC61B 10952
Proximity Label-MS Homo sapiens
72 LARP1 23367
Affinity Capture-MS Homo sapiens
73 REEP5 7905
Proximity Label-MS Homo sapiens
74 ELAVL2 1993
Affinity Capture-MS Homo sapiens
75 NUMA1 4926
Affinity Capture-MS Homo sapiens
76 MYCBP2 23077
Affinity Capture-MS Homo sapiens
77 Nup98  
Affinity Capture-MS Mus musculus
78 UPF1 5976
Affinity Capture-MS Homo sapiens
79 DHX36 170506
Affinity Capture-MS Homo sapiens
80 RAB5A 5868
Proximity Label-MS Homo sapiens
81 GLE1 2733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SRSF1 6426
Affinity Capture-MS Homo sapiens
83 ZFR 51663
Affinity Capture-MS Homo sapiens
84 HSD3B7 80270
Proximity Label-MS Homo sapiens
85 XAB2 56949
Affinity Capture-MS Homo sapiens
86 RPL3 6122
Affinity Capture-MS Homo sapiens
87 NUP43 348995
Proximity Label-MS Homo sapiens
88 NUP214 8021
Two-hybrid Homo sapiens
89 ZC3H11A  
Affinity Capture-MS Homo sapiens
90 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 MRPL15 29088
Affinity Capture-MS Homo sapiens
92 PPHLN1  
Affinity Capture-MS Homo sapiens
93 MRPL1  
Affinity Capture-MS Homo sapiens
94 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
95 Nup107  
Affinity Capture-MS Mus musculus
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
98 RAB9A 9367
Proximity Label-MS Homo sapiens
99 SRSF10 10772
Affinity Capture-MS Homo sapiens
100 DDRGK1 65992
Affinity Capture-MS Homo sapiens
101 RANBP1 5902
Affinity Capture-MS Homo sapiens
102 FYTTD1  
Affinity Capture-MS Homo sapiens
103 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
104 RAE1 8480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 H2AFX 3014
Affinity Capture-MS Homo sapiens
106 RPL13 6137
Affinity Capture-MS Homo sapiens
107 YBX1 4904
Affinity Capture-MS Homo sapiens
108 RNF43  
Proximity Label-MS Homo sapiens
109 MKRN1 23608
Affinity Capture-MS Homo sapiens
110 RBM45  
Affinity Capture-MS Homo sapiens
111 CDC40  
Affinity Capture-MS Homo sapiens
112 SF3A1 10291
Affinity Capture-MS Homo sapiens
113 YTHDC1  
Affinity Capture-MS Homo sapiens
114 SRSF12  
Affinity Capture-MS Homo sapiens
115 SNRPA 6626
Affinity Capture-MS Homo sapiens
116 NUP35 129401
Proximity Label-MS Homo sapiens
117 DDX58 23586
Affinity Capture-RNA Homo sapiens
118 NUP107 57122
Affinity Capture-MS Homo sapiens
119 NCL 4691
Affinity Capture-MS Homo sapiens
120 HNRNPL 3191
Affinity Capture-MS Homo sapiens
121 SEC62 7095
Proximity Label-MS Homo sapiens
122 HNRNPC 3183
Affinity Capture-MS Homo sapiens
123 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
124 RAB7A 7879
Proximity Label-MS Homo sapiens
125 RPUSD3  
Affinity Capture-MS Homo sapiens
126 CIT 11113
Affinity Capture-MS Homo sapiens
127 Ranbp2  
Affinity Capture-MS Mus musculus
128 MRPS9 64965
Affinity Capture-MS Homo sapiens
129 CASC3  
Affinity Capture-MS Homo sapiens
130 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUPL2 is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Disorders of transmembrane transporters TAS Reactome
Export of Viral Ribonucleoproteins from Nucleus TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA TAS Reactome
Glucose metabolism TAS Reactome
Glycolysis TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle TAS Reactome
Host Interactions of HIV factors IEA Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Interactions of Rev with host cellular proteins IEA Reactome
Interactions of Rev with host cellular proteins TAS Reactome
Interactions of Vpr with host cellular proteins TAS Reactome
Interferon Signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome
Late Phase of HIV Life Cycle TAS Reactome
M Phase TAS Reactome
Metabolism TAS Reactome
Metabolism of carbohydrates TAS Reactome
Metabolism of non-coding RNA TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Mitotic Prophase TAS Reactome
NEP/NS2 Interacts with the Cellular Export Machinery TAS Reactome
NS1 Mediated Effects on Host Pathways TAS Reactome
Nuclear Envelope Breakdown TAS Reactome
Nuclear import of Rev protein IEA Reactome
Nuclear Pore Complex (NPC) Disassembly TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
Regulation of Glucokinase by Glucokinase Regulatory Protein TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Rev-mediated nuclear export of HIV RNA TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
SLC transporter disorders TAS Reactome
snRNP Assembly TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA replication proteins IEA Reactome
SUMOylation of DNA replication proteins TAS Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of SUMOylation proteins TAS Reactome
SUMOylation of ubiquitinylation proteins TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript TAS Reactome
Transport of Mature mRNA Derived from an Intronless Transcript TAS Reactome
Transport of Mature mRNAs Derived from Intronless Transcripts TAS Reactome
Transport of Mature Transcript to Cytoplasm TAS Reactome
Transport of Ribonucleoproteins into the Host Nucleus TAS Reactome
Transport of the SLBP Dependant Mature mRNA TAS Reactome
Transport of the SLBP independent Mature mRNA TAS Reactome
tRNA processing TAS Reactome
tRNA processing in the nucleus TAS Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Messenger RNA Synthesis TAS Reactome
Vpr-mediated nuclear import of PICs TAS Reactome





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