Gene description for FAM91A1
Gene name family with sequence similarity 91, member A1
Gene symbol FAM91A1
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM91A1
ExoCarta ExoCarta_157769
Vesiclepedia VP_157769
Entrez Gene 157769
HGNC 26306
UniProt Q658Y4  
 FAM91A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for FAM91A1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 IDA
    vesicle tethering to Golgi GO:0099041 IBA
    vesicle tethering to Golgi GO:0099041 IDA
Subcellular Localization
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified FAM91A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
10
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FAM91A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LPPR4  
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 LHFPL4  
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 HOOK1  
Proximity Label-MS Homo sapiens
6 SLC22A8 9376
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 SSR2  
Affinity Capture-MS Homo sapiens
9 ATG9A 79065
Proximity Label-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 HDHD1  
Affinity Capture-MS Homo sapiens
12 C9orf78 51759
Affinity Capture-MS Homo sapiens
13 LAMP2 3920
Proximity Label-MS Homo sapiens
14 EDNRB 1910
Affinity Capture-MS Homo sapiens
15 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
16 SNX21  
Affinity Capture-MS Homo sapiens
17 STX4 6810
Proximity Label-MS Homo sapiens
18 CENPA  
Proximity Label-MS Homo sapiens
19 ZNF397  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 B3GAT1  
Proximity Label-MS Homo sapiens
21 TUBB 203068
Affinity Capture-MS Homo sapiens
22 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FAM174A 345757
Affinity Capture-MS Homo sapiens
24 RAB3B 5865
Proximity Label-MS Homo sapiens
25 FBXW7  
Affinity Capture-MS Homo sapiens
26 B4GALT2  
Affinity Capture-MS Homo sapiens
27 RHOB 388
Proximity Label-MS Homo sapiens
28 STX6 10228
Proximity Label-MS Homo sapiens
29 ATG7 10533
Affinity Capture-MS Homo sapiens
30 RAB35 11021
Proximity Label-MS Homo sapiens
31 EBAG9 9166
Proximity Label-MS Homo sapiens
32 FBXW5  
Affinity Capture-MS Homo sapiens
33 DHDH  
Affinity Capture-MS Homo sapiens
34 MARCKS 4082
Proximity Label-MS Homo sapiens
35 LAMTOR1 55004
Proximity Label-MS Homo sapiens
36 FAS 355
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 LMAN1 3998
Proximity Label-MS Homo sapiens
38 RAB5A 5868
Proximity Label-MS Homo sapiens
39 SULT1C4  
Affinity Capture-MS Homo sapiens
40 C17orf75 64149
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 KLHL34  
Affinity Capture-MS Homo sapiens
42 RAB4A 5867
Proximity Label-MS Homo sapiens
43 CDH1 999
Proximity Label-MS Homo sapiens
44 DIRAS3  
Proximity Label-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ARRDC3 57561
Affinity Capture-MS Homo sapiens
48 ANAPC4 29945
Affinity Capture-MS Homo sapiens
49 SYBU  
Affinity Capture-MS Homo sapiens
50 UBXN6 80700
Affinity Capture-MS Homo sapiens
51 PHLPP1  
Proximity Label-MS Homo sapiens
52 SV2A 9900
Affinity Capture-MS Homo sapiens
53 MAP7 9053
Affinity Capture-MS Homo sapiens
54 CXCR4 7852
Affinity Capture-MS Homo sapiens
55 AIFM1 9131
Affinity Capture-MS Homo sapiens
56 XPO1 7514
Affinity Capture-MS Homo sapiens
57 NUBP2 10101
Affinity Capture-MS Homo sapiens
58 BAG2 9532
Affinity Capture-MS Homo sapiens
59 UBXN7 26043
Affinity Capture-MS Homo sapiens
60 LAMP1 3916
Proximity Label-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 HOOK3 84376
Proximity Label-MS Homo sapiens
63 ARF6 382
Proximity Label-MS Homo sapiens
64 AQP3  
Affinity Capture-MS Homo sapiens
65 C12orf74  
Affinity Capture-MS Homo sapiens
66 C3orf18  
Affinity Capture-MS Homo sapiens
67 RPA3 6119
Proximity Label-MS Homo sapiens
68 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
69 AMZ1  
Affinity Capture-MS Homo sapiens
70 RAB9A 9367
Proximity Label-MS Homo sapiens
71 GOLGA1  
Proximity Label-MS Homo sapiens
72 METTL21B  
Affinity Capture-MS Homo sapiens
73 SLC18A1  
Affinity Capture-MS Homo sapiens
74 Kctd5  
Affinity Capture-MS Mus musculus
75 STYX  
Affinity Capture-MS Homo sapiens
76 HUWE1 10075
Affinity Capture-MS Homo sapiens
77 HVCN1 84329
Affinity Capture-MS Homo sapiens
78 CDC25A  
Affinity Capture-MS Homo sapiens
79 MAP2K2 5605
Affinity Capture-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 NSUN5P1  
Affinity Capture-MS Homo sapiens
82 TP53 7157
Affinity Capture-MS Homo sapiens
83 SLC5A5 6528
Affinity Capture-MS Homo sapiens
84 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TRIM52  
Affinity Capture-MS Homo sapiens
86 DDHD1 80821
Affinity Capture-MS Homo sapiens
87 CTAG1B  
Affinity Capture-MS Homo sapiens
88 HMGN5 79366
Affinity Capture-MS Homo sapiens
89 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 MAGEA9  
Affinity Capture-MS Homo sapiens
91 DRG1 4733
Affinity Capture-MS Homo sapiens
92 PPM1H  
Proximity Label-MS Homo sapiens
93 NUDT1  
Co-fractionation Homo sapiens
94 RAB2A 5862
Proximity Label-MS Homo sapiens
95 INF2 64423
Affinity Capture-MS Homo sapiens
96 KDELR2 11014
Affinity Capture-MS Homo sapiens
97 FIS1 51024
Affinity Capture-MS Homo sapiens
98 RAB11A 8766
Proximity Label-MS Homo sapiens
99 SHARPIN  
Affinity Capture-MS Homo sapiens
100 TXNIP 10628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 KRAS 3845
Proximity Label-MS Homo sapiens
102 RAB5C 5878
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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