Gene description for SLC27A4
Gene name solute carrier family 27 (fatty acid transporter), member 4
Gene symbol SLC27A4
Other names/aliases ACSVL4
FATP4
IPS
Species Homo sapiens
 Database cross references - SLC27A4
ExoCarta ExoCarta_10999
Vesiclepedia VP_10999
Entrez Gene 10999
HGNC 10998
MIM 604194
UniProt Q6P1M0  
 SLC27A4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC27A4
Molecular Function
    nucleotide binding GO:0000166 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IMP
    protein binding GO:0005515 IPI
    fatty acid transmembrane transporter activity GO:0015245 TAS
    very long-chain fatty acid-CoA ligase activity GO:0031957 IEA
    arachidonate-CoA ligase activity GO:0047676 IEA
    palmitoyl-CoA ligase activity GO:0090433 IDA
    oleoyl-CoA ligase activity GO:0090434 IBA
    oleoyl-CoA ligase activity GO:0090434 IDA
    oleoyl-CoA ligase activity GO:0090434 ISS
    oleate transmembrane transporter activity GO:1901480 IEA
Biological Process
    medium-chain fatty acid transport GO:0001579 IBA
    long-chain fatty acid metabolic process GO:0001676 IBA
    long-chain fatty acid metabolic process GO:0001676 IDA
    fatty acid metabolic process GO:0006631 IDA
    response to nutrient GO:0007584 IEA
    fatty acid transport GO:0015908 IMP
    long-chain fatty acid transport GO:0015909 IMP
    long-chain fatty acid transport GO:0015909 TAS
    very long-chain fatty acid catabolic process GO:0042760 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    skin development GO:0043588 IEA
    glucose import in response to insulin stimulus GO:0044381 ISS
    long-chain fatty acid import into cell GO:0044539 IBA
    long-chain fatty acid import into cell GO:0044539 IDA
    long-chain fatty acid import into cell GO:0044539 ISS
    negative regulation of insulin receptor signaling pathway GO:0046627 IDA
    establishment of localization in cell GO:0051649 IEA
    activation of GTPase activity GO:0090630 IDA
    transport across blood-brain barrier GO:0150104 NAS
    lipid transport across blood-brain barrier GO:1990379 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    microvillus GO:0005902 IEA
    membrane GO:0016020 HDA
    brush border membrane GO:0031526 IEA
 Experiment description of studies that identified SLC27A4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC27A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REEP5 7905
Proximity Label-MS Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 FSD2 123722
Affinity Capture-MS Homo sapiens
5 NTRK1 4914
Affinity Capture-MS Homo sapiens
6 Strn3  
Affinity Capture-MS Mus musculus
7 OTUB1 55611
Affinity Capture-MS Homo sapiens
8 Sod1 20655
Affinity Capture-MS Mus musculus
9 NUBP2 10101
Affinity Capture-MS Homo sapiens
10 GP9 2815
Affinity Capture-MS Homo sapiens
11 METTL7A 25840
Proximity Label-MS Homo sapiens
12 KIR2DL1  
Affinity Capture-MS Homo sapiens
13 GPN3  
Affinity Capture-MS Homo sapiens
14 PANX1 24145
Proximity Label-MS Homo sapiens
15 LDLRAD1  
Affinity Capture-MS Homo sapiens
16 HHIPL1 84439
Affinity Capture-MS Homo sapiens
17 Dennd6a  
Affinity Capture-MS Mus musculus
18 ZDHHC12  
Affinity Capture-MS Homo sapiens
19 RDH13  
Affinity Capture-MS Homo sapiens
20 SYP  
Affinity Capture-MS Homo sapiens
21 SLC39A4 55630
Affinity Capture-MS Homo sapiens
22 HSD3B7 80270
Proximity Label-MS Homo sapiens
23 TSPAN15 23555
Affinity Capture-MS Homo sapiens
24 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
25 FAM46B  
Two-hybrid Homo sapiens
26 EPS8 2059
Two-hybrid Homo sapiens
27 C9orf16  
Affinity Capture-MS Homo sapiens
28 OGFOD3 79701
Affinity Capture-MS Homo sapiens
29 CD79A  
Affinity Capture-MS Homo sapiens
30 PTPN1 5770
Affinity Capture-MS Homo sapiens
31 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
33 RIPK4  
Affinity Capture-MS Homo sapiens
34 EIF2B5 8893
Affinity Capture-MS Homo sapiens
35 NXF1 10482
Affinity Capture-RNA Homo sapiens
36 PCNA 5111
Affinity Capture-MS Homo sapiens
37 AMHR2  
Affinity Capture-MS Homo sapiens
38 KIAA1429 25962
Affinity Capture-MS Homo sapiens
39 PTPN5  
Affinity Capture-MS Homo sapiens
40 ARMC6 93436
Affinity Capture-MS Homo sapiens
41 MAPK6  
Affinity Capture-MS Homo sapiens
42 BECN1 8678
Affinity Capture-MS Homo sapiens
43 FAM20C 56975
Affinity Capture-MS Homo sapiens
44 INSRR 3645
Affinity Capture-MS Homo sapiens
45 Tpx2  
Affinity Capture-MS Mus musculus
46 ATP2A1 487
Proximity Label-MS Homo sapiens
47 B3GNT2 10678
Affinity Capture-MS Homo sapiens
48 ATG4B 23192
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
49 C3orf52  
Affinity Capture-MS Homo sapiens
50 SPRTN  
Affinity Capture-MS Homo sapiens
51 GPR182  
Affinity Capture-MS Homo sapiens
52 LPAR2 9170
Affinity Capture-MS Homo sapiens
53 PARP1 142
Proximity Label-MS Homo sapiens
54 RAB7A 7879
Proximity Label-MS Homo sapiens
55 CIB3  
Affinity Capture-MS Homo sapiens
56 LRBA 987
Affinity Capture-MS Homo sapiens
57 OTULIN 90268
Affinity Capture-MS Homo sapiens
58 RPN1 6184
Proximity Label-MS Homo sapiens
59 C1orf210  
Affinity Capture-MS Homo sapiens
60 TMBIM4  
Affinity Capture-MS Homo sapiens
61 C9orf72  
Affinity Capture-MS Homo sapiens
62 GNAI2 2771
Affinity Capture-MS Homo sapiens
63 PBXIP1 57326
Affinity Capture-MS Homo sapiens
64 CD63 967
Affinity Capture-MS Homo sapiens
65 PIGH  
Affinity Capture-MS Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 ATP2A3 489
Affinity Capture-MS Homo sapiens
68 CHRNA1  
Affinity Capture-MS Homo sapiens
69 SEC61B 10952
Proximity Label-MS Homo sapiens
70 UBXN4 23190
Affinity Capture-MS Homo sapiens
71 TUBB4A 10382
Affinity Capture-MS Homo sapiens
72 CCDC47 57003
Affinity Capture-MS Homo sapiens
73 SMUG1  
Affinity Capture-MS Homo sapiens
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