Gene description for INF2
Gene name inverted formin, FH2 and WH2 domain containing
Gene symbol INF2
Other names/aliases C14orf151
C14orf173
CMTDIE
FSGS5
pp9484
Species Homo sapiens
 Database cross references - INF2
ExoCarta ExoCarta_64423
Vesiclepedia VP_64423
Entrez Gene 64423
HGNC 23791
MIM 610982
UniProt Q27J81  
 INF2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for INF2
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
Biological Process
    actin filament polymerization GO:0030041 IBA
    regulation of mitochondrial fission GO:0090140 IMP
Subcellular Localization
    actin filament GO:0005884 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified INF2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
18
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
19
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
21
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
23
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TANGO6 79613
Affinity Capture-MS Homo sapiens
2 ARMC4  
Affinity Capture-MS Homo sapiens
3 ACTR2 10097
Affinity Capture-MS Homo sapiens
4 TUSC2  
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 VPS41 27072
Affinity Capture-MS Homo sapiens
7 OSBPL10  
Affinity Capture-MS Homo sapiens
8 PPP1CB 5500
Affinity Capture-MS Homo sapiens
9 MTCH1 23787
Proximity Label-MS Homo sapiens
10 BAG3 9531
Affinity Capture-MS Homo sapiens
11 Tpm1 22003
Affinity Capture-MS Mus musculus
12 FBXO7 25793
Affinity Capture-MS Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 GJA1 2697
Proximity Label-MS Homo sapiens
15 S100A6 6277
Affinity Capture-MS Homo sapiens
16 RAB9A 9367
Proximity Label-MS Homo sapiens
17 CRK 1398
Affinity Capture-MS Homo sapiens
18 ANAPC5 51433
Affinity Capture-MS Homo sapiens
19 Calml3  
Affinity Capture-MS Mus musculus
20 ACTC1 70
Affinity Capture-MS Homo sapiens
21 DBN1 1627
Affinity Capture-MS Homo sapiens
22 IFT122 55764
Affinity Capture-MS Homo sapiens
23 CALM1 801
Affinity Capture-MS Homo sapiens
24 TCF7L2  
Affinity Capture-MS Homo sapiens
25 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
26 HSD17B11 51170
Proximity Label-MS Homo sapiens
27 LAMP2 3920
Proximity Label-MS Homo sapiens
28 DNAJC25 548645
Proximity Label-MS Homo sapiens
29 MYO5C 55930
Affinity Capture-MS Homo sapiens
30 PTPN1 5770
Proximity Label-MS Homo sapiens
31 Actb 11461
Affinity Capture-MS Mus musculus
32 RIPK1 8737
Affinity Capture-MS Homo sapiens
33 STX4 6810
Proximity Label-MS Homo sapiens
34 ESRP2 80004
Affinity Capture-MS Homo sapiens
35 GCN1L1 10985
Co-fractionation Homo sapiens
36 CEP97 79598
Affinity Capture-MS Homo sapiens
37 PI4KA 5297
Affinity Capture-MS Homo sapiens
38 PEX1 5189
Affinity Capture-MS Homo sapiens
39 PPP1CC 5501
Affinity Capture-MS Homo sapiens
40 CAPZB 832
Affinity Capture-MS Homo sapiens
41 PER1  
Affinity Capture-MS Homo sapiens
42 PLEKHG4  
Affinity Capture-MS Homo sapiens
43 CPLX2 10814
Affinity Capture-MS Homo sapiens
44 B3GAT1  
Proximity Label-MS Homo sapiens
45 ERF  
Affinity Capture-MS Homo sapiens
46 HSPA2 3306
Affinity Capture-MS Homo sapiens
47 KIF23 9493
Affinity Capture-MS Homo sapiens
48 CFAP97  
Affinity Capture-MS Homo sapiens
49 COPE 11316
Affinity Capture-MS Homo sapiens
50 BRAT1 221927
Affinity Capture-MS Homo sapiens
51 CALD1 800
Affinity Capture-MS Homo sapiens
52 RAB3B 5865
Proximity Label-MS Homo sapiens
53 PRC1 9055
Affinity Capture-MS Homo sapiens
54 IQGAP1 8826
Affinity Capture-MS Homo sapiens
55 CALM3 808
Affinity Capture-MS Homo sapiens
56 ADD1 118
Affinity Capture-MS Homo sapiens
57 SSR1 6745
Proximity Label-MS Homo sapiens
58 PIP 5304
Affinity Capture-MS Homo sapiens
59 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
60 Flot2 14252
Affinity Capture-MS Mus musculus
61 HAUS6  
Affinity Capture-MS Homo sapiens
62 DYNLL1 8655
Affinity Capture-MS Homo sapiens
63 RPN2 6185
Proximity Label-MS Homo sapiens
64 STX6 10228
Proximity Label-MS Homo sapiens
65 PPFIBP1 8496
Affinity Capture-MS Homo sapiens
66 SLC25A46 91137
Proximity Label-MS Homo sapiens
67 STXBP3 6814
Affinity Capture-MS Homo sapiens
68 ANAPC7 51434
Affinity Capture-MS Homo sapiens
69 PFN2 5217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CST1  
Affinity Capture-MS Homo sapiens
71 VPS16 64601
Affinity Capture-MS Homo sapiens
72 RAB35 11021
Proximity Label-MS Homo sapiens
73 RNF123 63891
Affinity Capture-MS Homo sapiens
74 Erh  
Affinity Capture-MS Mus musculus
75 IFT140 9742
Affinity Capture-MS Homo sapiens
76 Lima1  
Affinity Capture-MS Mus musculus
77 KIF14 9928
Affinity Capture-MS Homo sapiens
78 HSPA8 3312
Affinity Capture-MS Homo sapiens
79 NUP155 9631
Proximity Label-MS Homo sapiens
80 KIAA1715 80856
Proximity Label-MS Homo sapiens
81 PFN1 5216
Proximity Label-MS Homo sapiens
82 CALM2 805
Affinity Capture-MS Homo sapiens
83 RAB5A 5868
Proximity Label-MS Homo sapiens
84 BANP  
Affinity Capture-MS Homo sapiens
85 MYO18A 399687
Affinity Capture-MS Homo sapiens
86 MTCH2 23788
Proximity Label-MS Homo sapiens
87 EMD 2010
Proximity Label-MS Homo sapiens
88 SMG8 55181
Affinity Capture-MS Homo sapiens
89 SBF2 81846
Affinity Capture-MS Homo sapiens
90 CXADR 1525
Proximity Label-MS Homo sapiens
91 SPG11 80208
Affinity Capture-MS Homo sapiens
92 TUBA1A 7846
Affinity Capture-MS Homo sapiens
93 Arrb2  
Affinity Capture-MS Mus musculus
94 ARHGEF1 9138
Affinity Capture-MS Homo sapiens
95 PANK4 55229
Affinity Capture-MS Homo sapiens
96 PDXDC1 23042
Affinity Capture-MS Homo sapiens
97 CAMK2G 818
Affinity Capture-MS Homo sapiens
98 BTF3 689
Affinity Capture-MS Homo sapiens
99 MYH9 4627
Affinity Capture-MS Homo sapiens
100 VCP 7415
Affinity Capture-MS Homo sapiens
101 FOXK2  
Affinity Capture-MS Homo sapiens
102 RIN1 9610
Affinity Capture-MS Homo sapiens
103 POLD1 5424
Affinity Capture-MS Homo sapiens
104 HPS3 84343
Affinity Capture-MS Homo sapiens
105 ALDH3B1 221
Affinity Capture-MS Homo sapiens
106 TRIM32 22954
Affinity Capture-MS Homo sapiens
107 ACTB 60
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 MYH11 4629
Affinity Capture-MS Homo sapiens
109 Coro1c 23790
Affinity Capture-MS Mus musculus
110 CCZ1 51622
Affinity Capture-MS Homo sapiens
111 DYNLL2 140735
Affinity Capture-MS Homo sapiens
112 TSTD2  
Affinity Capture-MS Homo sapiens
113 RHOT2 89941
Proximity Label-MS Homo sapiens
114 ELOVL5 60481
Proximity Label-MS Homo sapiens
115 CAMKK2 10645
Affinity Capture-MS Homo sapiens
116 GAK 2580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 SEC61B 10952
Proximity Label-MS Homo sapiens
118 BBS10  
Affinity Capture-MS Homo sapiens
119 PIPSL 266971
Affinity Capture-MS Homo sapiens
120 RMDN3 55177
Proximity Label-MS Homo sapiens
121 PHLDA1 22822
Affinity Capture-MS Homo sapiens
122 PEX6  
Affinity Capture-MS Homo sapiens
123 REEP5 7905
Proximity Label-MS Homo sapiens
124 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 NAB2 4665
Affinity Capture-MS Homo sapiens
126 LIMA1 51474
Affinity Capture-MS Homo sapiens
127 ASCC3 10973
Affinity Capture-MS Homo sapiens
128 FUK 197258
Affinity Capture-MS Homo sapiens
129 ZNF195  
Affinity Capture-MS Homo sapiens
130 RGL3  
Affinity Capture-MS Homo sapiens
131 Myh9 17886
Affinity Capture-MS Mus musculus
132 RAB7A 7879
Proximity Label-MS Homo sapiens
133 HERC4 26091
Affinity Capture-MS Homo sapiens
134 LRRC59 55379
Proximity Label-MS Homo sapiens
135 PANX1 24145
Proximity Label-MS Homo sapiens
136 ECT2 1894
Affinity Capture-MS Homo sapiens
137 SNAPC4  
Affinity Capture-MS Homo sapiens
138 CCP110  
Affinity Capture-MS Homo sapiens
139 RLIM 51132
Affinity Capture-MS Homo sapiens
140 SETX  
Affinity Capture-MS Homo sapiens
141 VPS13C 54832
Affinity Capture-MS Homo sapiens
142 SLC25A31 83447
Affinity Capture-MS Homo sapiens
143 BCAP31 10134
Proximity Label-MS Homo sapiens
144 HSD3B7 80270
Proximity Label-MS Homo sapiens
145 CBWD3  
Affinity Capture-MS Homo sapiens
146 STIM1 6786
Proximity Label-MS Homo sapiens
147 CSNK2A1 1457
Biochemical Activity Homo sapiens
148 FKBP8 23770
Proximity Label-MS Homo sapiens
149 MYO19  
Affinity Capture-MS Homo sapiens
150 HK2 3099
Affinity Capture-MS Homo sapiens
151 SSH3 54961
Affinity Capture-MS Homo sapiens
152 SBF1 6305
Affinity Capture-MS Homo sapiens
153 UBE2R2 54926
Two-hybrid Homo sapiens
154 MYO1C 4641
Affinity Capture-MS Homo sapiens
155 OCIAD1 54940
Proximity Label-MS Homo sapiens
156 NXF1 10482
Affinity Capture-RNA Homo sapiens
157 HAUS5 23354
Affinity Capture-MS Homo sapiens
158 BIRC6 57448
Affinity Capture-MS Homo sapiens
159 PI4K2B 55300
Affinity Capture-MS Homo sapiens
160 TUBGCP6 85378
Affinity Capture-MS Homo sapiens
161 SYNPO 11346
Affinity Capture-MS Homo sapiens
162 Flnb 286940
Affinity Capture-MS Mus musculus
163 Uso1 56041
Affinity Capture-MS Mus musculus
164 FAM91A1 157769
Affinity Capture-MS Homo sapiens
165 SPOP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
166 NPRL3  
Affinity Capture-MS Homo sapiens
167 AHR 196
Affinity Capture-MS Homo sapiens
168 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 SHKBP1  
Affinity Capture-MS Homo sapiens
170 N4BP2L2 10443
Affinity Capture-MS Homo sapiens
171 RICTOR 253260
Affinity Capture-MS Homo sapiens
172 ETV3  
Affinity Capture-MS Homo sapiens
173 GET4 51608
Affinity Capture-MS Homo sapiens
174 RPN1 6184
Proximity Label-MS Homo sapiens
175 XRCC3  
Affinity Capture-MS Homo sapiens
176 CD55 1604
Co-fractionation Homo sapiens
177 CPSF3L 54973
Affinity Capture-MS Homo sapiens
178 ANKRD28 23243
Affinity Capture-MS Homo sapiens
179 ARMCX5  
Affinity Capture-MS Homo sapiens
180 AKAP1 8165
Proximity Label-MS Homo sapiens
181 MTR 4548
Affinity Capture-MS Homo sapiens
182 ARHGEF4  
Affinity Capture-MS Homo sapiens
183 HAUS3  
Affinity Capture-MS Homo sapiens
184 STUB1 10273
Affinity Capture-MS Homo sapiens
185 PRR14L 253143
Affinity Capture-MS Homo sapiens
186 HERC1 8925
Affinity Capture-MS Homo sapiens
187 ARAP3 64411
Affinity Capture-MS Homo sapiens
188 PLEKHH3  
Affinity Capture-MS Homo sapiens
189 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
190 Tmod3 50875
Affinity Capture-MS Mus musculus
191 CTR9 9646
Affinity Capture-MS Homo sapiens
192 RPAP1  
Affinity Capture-MS Homo sapiens
193 AP1G2 8906
Affinity Capture-MS Homo sapiens
194 RAD17  
Affinity Capture-MS Homo sapiens
195 USP34 9736
Affinity Capture-MS Homo sapiens
196 PPIP5K1 9677
Affinity Capture-MS Homo sapiens
197 RGPD8  
Affinity Capture-MS Homo sapiens
198 RNF31 55072
Affinity Capture-MS Homo sapiens
199 Myo1c 17913
Affinity Capture-MS Mus musculus
200 RSPRY1 89970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 VWA9  
Affinity Capture-MS Homo sapiens
202 TRIM65 201292
Affinity Capture-MS Homo sapiens
203 CAPZA2 830
Affinity Capture-MS Homo sapiens
204 LSS 4047
Affinity Capture-MS Homo sapiens
205 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
206 PALD1 27143
Affinity Capture-MS Homo sapiens
207 WDR81 124997
Affinity Capture-MS Homo sapiens
208 RAB4A 5867
Proximity Label-MS Homo sapiens
209 Myh10 77579
Affinity Capture-MS Mus musculus
210 VPS33A 65082
Affinity Capture-MS Homo sapiens
211 PXMP2  
Proximity Label-MS Homo sapiens
212 UBB 7314
Affinity Capture-MS Homo sapiens
213 ERGIC2 51290
Proximity Label-MS Homo sapiens
214 ACTG1 71
Affinity Capture-MS Homo sapiens
215 BAG5 9529
Affinity Capture-MS Homo sapiens
216 MOV10 4343
Affinity Capture-RNA Homo sapiens
217 Mapre1 13589
Affinity Capture-MS Mus musculus
218 QRICH1  
Affinity Capture-MS Homo sapiens
219 SEC62 7095
Proximity Label-MS Homo sapiens
220 FIS1 51024
Proximity Label-MS Homo sapiens
221 NEDD1 121441
Affinity Capture-MS Homo sapiens
222 DNAJB4 11080
Affinity Capture-MS Homo sapiens
223 FLNA 2316
Affinity Capture-MS Homo sapiens
224 NACC2  
Affinity Capture-MS Homo sapiens
225 RAB11A 8766
Proximity Label-MS Homo sapiens
226 CIT 11113
Affinity Capture-MS Homo sapiens
227 WDR59 79726
Affinity Capture-MS Homo sapiens
228 Flot1 14251
Affinity Capture-MS Mus musculus
229 EPHA2 1969
Proximity Label-MS Homo sapiens
230 SERBP1 26135
Affinity Capture-MS Homo sapiens
231 DNAJC1 64215
Proximity Label-MS Homo sapiens
232 KRAS 3845
Proximity Label-MS Homo sapiens
233 BDKRB2  
Two-hybrid Homo sapiens
234 CKAP4 10970
Proximity Label-MS Homo sapiens
235 Sept9  
Affinity Capture-MS Mus musculus
236 RPA3 6119
Proximity Label-MS Homo sapiens
237 RAB20 55647
Affinity Capture-MS Homo sapiens
238 HSPA1B 3304
Affinity Capture-MS Homo sapiens
239 DERL1 79139
Proximity Label-MS Homo sapiens
240 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which INF2 is involved
No pathways found





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