Gene description for STBD1
Gene name starch binding domain 1
Gene symbol STBD1
Other names/aliases GENEX3414
GENX-3414
Species Homo sapiens
 Database cross references - STBD1
ExoCarta ExoCarta_8987
Vesiclepedia VP_8987
Entrez Gene 8987
HGNC 24854
MIM 607406
UniProt O95210  
 STBD1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STBD1
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    polysaccharide binding GO:0030247 IDA
    cargo receptor activity GO:0038024 IEA
    glycogen binding GO:2001069 IDA
    starch binding GO:2001070 IEA
Biological Process
    glycogen catabolic process GO:0005980 IMP
    vesicle-mediated transport GO:0016192 IEA
    intracellular transport GO:0046907 IGI
    glycophagy GO:0061723 IMP
    substrate localization to autophagosome GO:0061753 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    T-tubule GO:0030315 IDA
    phagophore assembly site membrane GO:0034045 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    tertiary granule membrane GO:0070821 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified STBD1 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STBD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABARAPL1 23710
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 PPP1R3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 GJA1 2697
Proximity Label-MS Homo sapiens
7 PPP1R3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GJD3  
Proximity Label-MS Homo sapiens
9 DNAJC25 548645
Proximity Label-MS Homo sapiens
10 MID1 4281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PTPN1 5770
Proximity Label-MS Homo sapiens
12 STX4 6810
Proximity Label-MS Homo sapiens
13 GYG1 2992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FIS1 51024
Proximity Label-MS Homo sapiens
15 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
16 RAB3B 5865
Proximity Label-MS Homo sapiens
17 SSR1 6745
Proximity Label-MS Homo sapiens
18 MARCH5  
Proximity Label-MS Homo sapiens
19 DNAJC16  
Proximity Label-MS Homo sapiens
20 SLC25A46 91137
Proximity Label-MS Homo sapiens
21 RAB35 11021
Proximity Label-MS Homo sapiens
22 LMAN1 3998
Proximity Label-MS Homo sapiens
23 NUP155 9631
Proximity Label-MS Homo sapiens
24 KIAA1715 80856
Proximity Label-MS Homo sapiens
25 PXMP2  
Proximity Label-MS Homo sapiens
26 RAB5A 5868
Proximity Label-MS Homo sapiens
27 GYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MTCH2 23788
Proximity Label-MS Homo sapiens
29 EMD 2010
Proximity Label-MS Homo sapiens
30 CXADR 1525
Proximity Label-MS Homo sapiens
31 RAB4A 5867
Proximity Label-MS Homo sapiens
32 GABARAP 11337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HMGN1  
Affinity Capture-MS Homo sapiens
34 GYS1 2997
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 RPN1 6184
Proximity Label-MS Homo sapiens
36 RHOT2 89941
Proximity Label-MS Homo sapiens
37 ELOVL5 60481
Proximity Label-MS Homo sapiens
38 SEC61B 10952
Proximity Label-MS Homo sapiens
39 WDFY1 57590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RMDN3 55177
Proximity Label-MS Homo sapiens
41 REEP5 7905
Proximity Label-MS Homo sapiens
42 SEC63 11231
Proximity Label-MS Homo sapiens
43 COL4A2 1284
Affinity Capture-MS Homo sapiens
44 RPN2 6185
Proximity Label-MS Homo sapiens
45 LRRC59 55379
Proximity Label-MS Homo sapiens
46 PANX1 24145
Proximity Label-MS Homo sapiens
47 CAV2 858
Affinity Capture-MS Homo sapiens
48 BCAP31 10134
Proximity Label-MS Homo sapiens
49 HSD3B7 80270
Proximity Label-MS Homo sapiens
50 STIM1 6786
Proximity Label-MS Homo sapiens
51 FKBP8 23770
Proximity Label-MS Homo sapiens
52 CCDC155  
Two-hybrid Homo sapiens
53 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 GPRASP2  
Affinity Capture-MS Homo sapiens
55 AMY1C 278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 EPM2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ATP2A1 487
Proximity Label-MS Homo sapiens
58 RAB9A 9367
Proximity Label-MS Homo sapiens
59 DHFRL1  
Proximity Label-MS Homo sapiens
60 CYP2C9  
Proximity Label-MS Homo sapiens
61 PRKAB2 5565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PPP1R3B  
Affinity Capture-MS Homo sapiens
63 AKAP1 8165
Proximity Label-MS Homo sapiens
64 ZNF787  
Affinity Capture-MS Homo sapiens
65 RNF43  
Proximity Label-MS Homo sapiens
66 AGL 178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TP53 7157
Affinity Capture-MS Homo sapiens
68 PYGL 5836
Affinity Capture-MS Homo sapiens
69 GABARAPL2 11345
Affinity Capture-MS Homo sapiens
70 ERGIC1 57222
Proximity Label-MS Homo sapiens
71 DDX58 23586
Affinity Capture-RNA Homo sapiens
72 ERGIC2 51290
Proximity Label-MS Homo sapiens
73 XPO5 57510
Affinity Capture-MS Homo sapiens
74 PYGM 5837
Affinity Capture-MS Homo sapiens
75 MOV10 4343
Affinity Capture-RNA Homo sapiens
76 SEC62 7095
Proximity Label-MS Homo sapiens
77 B3GAT1  
Proximity Label-MS Homo sapiens
78 PYGB 5834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RAB7A 7879
Proximity Label-MS Homo sapiens
80 RAB11A 8766
Proximity Label-MS Homo sapiens
81 GBE1 2632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GYS2 2998
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 DNAJC1 64215
Proximity Label-MS Homo sapiens
84 RAB5C 5878
Proximity Label-MS Homo sapiens
85 CKAP4 10970
Proximity Label-MS Homo sapiens
86 DERL1 79139
Proximity Label-MS Homo sapiens
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