Gene description for TACC1
Gene name transforming, acidic coiled-coil containing protein 1
Gene symbol TACC1
Other names/aliases Ga55
Species Homo sapiens
 Database cross references - TACC1
ExoCarta ExoCarta_6867
Vesiclepedia VP_6867
Entrez Gene 6867
HGNC 11522
MIM 605301
UniProt O75410  
 TACC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for TACC1
Molecular Function
    protein binding GO:0005515 IPI
    nuclear receptor binding GO:0016922 IDA
    nuclear estrogen receptor binding GO:0030331 IDA
    nuclear receptor coactivator activity GO:0030374 IMP
    nuclear glucocorticoid receptor binding GO:0035259 IDA
    nuclear retinoic acid receptor binding GO:0042974 IDA
    peroxisome proliferator activated receptor binding GO:0042975 IDA
    nuclear retinoid X receptor binding GO:0046965 IDA
    nuclear thyroid hormone receptor binding GO:0046966 IDA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    mitotic spindle organization GO:0007052 IEA
    nuclear migration GO:0007097 IBA
    cerebral cortex development GO:0021987 IBA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    cell division GO:0051301 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    membrane GO:0016020 IEA
    midbody GO:0030496 IEA
 Experiment description of studies that identified TACC1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TACC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 TPGS1  
Affinity Capture-MS Homo sapiens
3 SNRPG 6637
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 MTCH1 23787
Proximity Label-MS Homo sapiens
5 STAT2 6773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MARCKS 4082
Proximity Label-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 TUSC3 7991
Affinity Capture-MS Homo sapiens
10 HSD17B11 51170
Proximity Label-MS Homo sapiens
11 DNAJC25 548645
Proximity Label-MS Homo sapiens
12 PTPN1 5770
Proximity Label-MS Homo sapiens
13 STX4 6810
Proximity Label-MS Homo sapiens
14 TACC2 10579
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 B3GAT1  
Proximity Label-MS Homo sapiens
16 ZFHX3  
Two-hybrid Homo sapiens
17 SOSTDC1  
Affinity Capture-MS Homo sapiens
18 RAB3B 5865
Proximity Label-MS Homo sapiens
19 POC1B 282809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SSR1 6745
Proximity Label-MS Homo sapiens
21 MARCH5  
Proximity Label-MS Homo sapiens
22 DDOST 1650
Affinity Capture-MS Homo sapiens
23 RPN2 6185
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 EXD2  
Proximity Label-MS Homo sapiens
25 STX6 10228
Proximity Label-MS Homo sapiens
26 SLC25A46 91137
Proximity Label-MS Homo sapiens
27 RAB35 11021
Proximity Label-MS Homo sapiens
28 BTRC 8945
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
29 KNSTRN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 EBAG9 9166
Proximity Label-MS Homo sapiens
31 NIF3L1 60491
Co-fractionation Homo sapiens
32 METTL7A 25840
Proximity Label-MS Homo sapiens
33 LMAN1 3998
Proximity Label-MS Homo sapiens
34 NUP155 9631
Proximity Label-MS Homo sapiens
35 KIAA1715 80856
Proximity Label-MS Homo sapiens
36 PXMP2  
Proximity Label-MS Homo sapiens
37 AURKA 6790
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 MTCH2 23788
Proximity Label-MS Homo sapiens
39 EMD 2010
Proximity Label-MS Homo sapiens
40 RB1CC1 9821
Affinity Capture-MS Homo sapiens
41 CXADR 1525
Proximity Label-MS Homo sapiens
42 MAPRE1 22919
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RAB4A 5867
Proximity Label-MS Homo sapiens
44 HTT 3064
Two-hybrid Homo sapiens
45 ITSN2 50618
Two-hybrid Homo sapiens
46 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TUBA1B 10376
Affinity Capture-MS Homo sapiens
48 MEMO1 51072
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 BARD1 580
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 S100A11 6282
Co-fractionation Homo sapiens
51 CKAP5 9793
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
52 PEX14 5195
Proximity Label-MS Homo sapiens
53 RPN1 6184
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 STX5 6811
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
55 LYST 1130
Affinity Capture-MS Homo sapiens
56 RHOT2 89941
Proximity Label-MS Homo sapiens
57 ELOVL5 60481
Proximity Label-MS Homo sapiens
58 SEC61B 10952
Proximity Label-MS Homo sapiens
59 Slain1  
Affinity Capture-MS Mus musculus
60 RMDN3 55177
Proximity Label-MS Homo sapiens
61 REEP5 7905
Proximity Label-MS Homo sapiens
62 YEATS4  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
63 RNF41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LRRC59 55379
Proximity Label-MS Homo sapiens
66 PANX1 24145
Proximity Label-MS Homo sapiens
67 FAM50B  
Two-hybrid Homo sapiens
68 RNF43  
Proximity Label-MS Homo sapiens
69 MEX3A  
Affinity Capture-RNA Homo sapiens
70 BCAP31 10134
Proximity Label-MS Homo sapiens
71 HSD3B7 80270
Proximity Label-MS Homo sapiens
72 CUL3 8452
Affinity Capture-MS Homo sapiens
73 STIM1 6786
Proximity Label-MS Homo sapiens
74 TUBB4B 10383
Affinity Capture-MS Homo sapiens
75 ERCC4  
Two-hybrid Homo sapiens
76 FKBP8 23770
Proximity Label-MS Homo sapiens
77 FSD2 123722
Affinity Capture-MS Homo sapiens
78 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
79 OCIAD1 54940
Proximity Label-MS Homo sapiens
80 THRA  
Two-hybrid Homo sapiens
81 AURKB 9212
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 MAPRE3  
Proximity Label-MS Homo sapiens
83 ATP2A1 487
Proximity Label-MS Homo sapiens
84 RAB9A 9367
Proximity Label-MS Homo sapiens
85 DHFRL1  
Proximity Label-MS Homo sapiens
86 CYP2C9  
Proximity Label-MS Homo sapiens
87 PMFBP1 83449
Affinity Capture-MS Homo sapiens
88 BRD3 8019
Affinity Capture-MS Homo sapiens
89 KRT222 125113
Affinity Capture-MS Homo sapiens
90 AKAP1 8165
Proximity Label-MS Homo sapiens
91 OST4  
Affinity Capture-MS Homo sapiens
92 Esrrb  
Affinity Capture-MS Mus musculus
93 PLXNB2 23654
Co-fractionation Homo sapiens
94 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 KAT2A  
Reconstituted Complex Homo sapiens
96 PFDN1 5201
Affinity Capture-MS Homo sapiens
97 ZNF48  
Two-hybrid Homo sapiens
98 ERGIC1 57222
Proximity Label-MS Homo sapiens
99 RAB5A 5868
Proximity Label-MS Homo sapiens
100 ERGIC2 51290
Proximity Label-MS Homo sapiens
101 LSM7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
102 KDM1A 23028
Two-hybrid Homo sapiens
103 SEC62 7095
Proximity Label-MS Homo sapiens
104 FIS1 51024
Proximity Label-MS Homo sapiens
105 RAB7A 7879
Proximity Label-MS Homo sapiens
106 RAB11A 8766
Proximity Label-MS Homo sapiens
107 SLC9A3R1 9368
Co-fractionation Homo sapiens
108 KXD1 79036
Affinity Capture-MS Homo sapiens
109 ACACB 32
Affinity Capture-MS Homo sapiens
110 DNAJC1 64215
Proximity Label-MS Homo sapiens
111 KRAS 3845
Proximity Label-MS Homo sapiens
112 RAB5C 5878
Proximity Label-MS Homo sapiens
113 SH2D4A 63898
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
114 CKAP4 10970
Proximity Label-MS Homo sapiens
115 TDRD7 23424
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
116 PRKRIR  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
117 C12orf57 113246
Co-fractionation Homo sapiens
118 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TACC1 is involved
No pathways found





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