Gene description for DHRS7
Gene name dehydrogenase/reductase (SDR family) member 7
Gene symbol DHRS7
Other names/aliases CGI-86
SDR34C1
retDSR4
retSDR4
Species Homo sapiens
 Database cross references - DHRS7
ExoCarta ExoCarta_51635
Vesiclepedia VP_51635
Entrez Gene 51635
HGNC 21524
MIM 612833
UniProt Q9Y394  
 DHRS7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for DHRS7
Molecular Function
    carbonyl reductase (NADPH) activity GO:0004090 IDA
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IDA
    all-trans-retinol dehydrogenase (NADP+) activity GO:0052650 IDA
Biological Process
    retinol metabolic process GO:0042572 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified DHRS7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DHRS7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 RXFP1  
Affinity Capture-MS Homo sapiens
3 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
7 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 COPG1 22820
Affinity Capture-MS Homo sapiens
9 IL20RB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GJD3  
Proximity Label-MS Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 DNAJC25 548645
Proximity Label-MS Homo sapiens
14 PTPN1 5770
Proximity Label-MS Homo sapiens
15 COPA 1314
Affinity Capture-MS Homo sapiens
16 RTN4 57142
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 HTR3E  
Affinity Capture-MS Homo sapiens
19 COPB2 9276
Affinity Capture-MS Homo sapiens
20 TREML2 79865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 PIGH  
Affinity Capture-MS Homo sapiens
23 SCAP  
Affinity Capture-MS Homo sapiens
24 C3orf52  
Affinity Capture-MS Homo sapiens
25 TTYH1  
Affinity Capture-MS Homo sapiens
26 ITGA8 8516
Affinity Capture-MS Homo sapiens
27 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SACM1L 22908
Two-hybrid Homo sapiens
29 MECP2 4204
Affinity Capture-MS Homo sapiens
30 CPNE5 57699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MARCKS 4082
Proximity Label-MS Homo sapiens
32 LMAN1 3998
Proximity Label-MS Homo sapiens
33 KIAA1715 80856
Proximity Label-MS Homo sapiens
34 IL9R  
Affinity Capture-MS Homo sapiens
35 PANX1 24145
Proximity Label-MS Homo sapiens
36 LMNA 4000
Proximity Label-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 SCN1B  
Affinity Capture-MS Homo sapiens
39 COPE 11316
Affinity Capture-MS Homo sapiens
40 LCTL  
Affinity Capture-MS Homo sapiens
41 BTN2A3P  
Affinity Capture-MS Homo sapiens
42 CHRNB2  
Affinity Capture-MS Homo sapiens
43 PCDHGC4  
Affinity Capture-MS Homo sapiens
44 VAPB 9217
Affinity Capture-MS Homo sapiens
45 TMPRSS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PLXDC2 84898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RPN1 6184
Proximity Label-MS Homo sapiens
48 RNF13 11342
Affinity Capture-MS Homo sapiens
49 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ELOVL5 60481
Proximity Label-MS Homo sapiens
51 SEC61B 10952
Proximity Label-MS Homo sapiens
52 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CLRN2  
Affinity Capture-MS Homo sapiens
54 HRH1  
Two-hybrid Homo sapiens
55 REEP5 7905
Proximity Label-MS Homo sapiens
56 PCDHGA4  
Affinity Capture-MS Homo sapiens
57 FAM189B  
Affinity Capture-MS Homo sapiens
58 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RPN2 6185
Proximity Label-MS Homo sapiens
61 LRRC59 55379
Proximity Label-MS Homo sapiens
62 LMNB1 4001
Proximity Label-MS Homo sapiens
63 ZDHHC12  
Affinity Capture-MS Homo sapiens
64 PTCH2  
Affinity Capture-MS Homo sapiens
65 NPTN 27020
Affinity Capture-MS Homo sapiens
66 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 IL22RA1 58985
Affinity Capture-MS Homo sapiens
68 BCAP31 10134
Proximity Label-MS Homo sapiens
69 HSD3B7 80270
Proximity Label-MS Homo sapiens
70 STIM1 6786
Proximity Label-MS Homo sapiens
71 PCDHA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 GPM6B 2824
Affinity Capture-MS Homo sapiens
73 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CNR2  
Affinity Capture-MS Homo sapiens
76 ATP2A1 487
Proximity Label-MS Homo sapiens
77 EVA1B 55194
Affinity Capture-MS Homo sapiens
78 TGFA  
Affinity Capture-MS Homo sapiens
79 SLC22A4 6583
Affinity Capture-MS Homo sapiens
80 C9orf91 203197
Affinity Capture-MS Homo sapiens
81 PCDHAC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 KCNA2  
Affinity Capture-MS Homo sapiens
83 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
84 SIDT2 51092
Affinity Capture-MS Homo sapiens
85 OR10H2  
Affinity Capture-MS Homo sapiens
86 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TSPAN17 26262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 TLR5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NUP35 129401
Proximity Label-MS Homo sapiens
90 ERGIC1 57222
Proximity Label-MS Homo sapiens
91 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 SEC62 7095
Proximity Label-MS Homo sapiens
94 RAB7A 7879
Proximity Label-MS Homo sapiens
95 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 MARCH4  
Affinity Capture-MS Homo sapiens
97 DNAJC1 64215
Proximity Label-MS Homo sapiens
98 RAB5C 5878
Proximity Label-MS Homo sapiens
99 ETV5  
Two-hybrid Homo sapiens
100 CKAP4 10970
Proximity Label-MS Homo sapiens
101 CCR1  
Affinity Capture-MS Homo sapiens
102 ESYT1 23344
Affinity Capture-MS Homo sapiens
103 DERL1 79139
Proximity Label-MS Homo sapiens
104 POPDC2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DHRS7 is involved
No pathways found





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