Gene description for HMOX2
Gene name heme oxygenase 2
Gene symbol HMOX2
Other names/aliases HO-2
Species Homo sapiens
 Database cross references - HMOX2
ExoCarta ExoCarta_3163
Vesiclepedia VP_3163
Entrez Gene 3163
HGNC 5014
MIM 141251
UniProt P30519  
 HMOX2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for HMOX2
Molecular Function
    heme oxygenase (decyclizing) activity GO:0004392 IBA
    heme oxygenase (decyclizing) activity GO:0004392 IDA
    protein binding GO:0005515 IPI
    heme binding GO:0020037 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    response to hypoxia GO:0001666 IDA
    heme oxidation GO:0006788 IBA
    response to oxidative stress GO:0006979 IBA
    heme catabolic process GO:0042167 IBA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    specific granule membrane GO:0035579 TAS
 Experiment description of studies that identified HMOX2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
8
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
9
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
14
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HMOX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 EMC4 51234
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 P4HB 5034
Cross-Linking-MS (XL-MS) Homo sapiens
5 HSD17B11 51170
Proximity Label-MS Homo sapiens
6 TMEM14B  
Two-hybrid Homo sapiens
7 POR 5447
Co-fractionation Homo sapiens
8 DNAJC8 22826
Cross-Linking-MS (XL-MS) Homo sapiens
9 ATP6V1A 523
Co-fractionation Homo sapiens
10 NDUFS1 4719
Co-fractionation Homo sapiens
11 MARCKS 4082
Proximity Label-MS Homo sapiens
12 LAMP3  
Proximity Label-MS Homo sapiens
13 SETDB1  
Two-hybrid Homo sapiens
14 TMEM205 374882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ASIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ASGR2  
Two-hybrid Homo sapiens
17 ADPGK 83440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 APOE 348
Co-fractionation Homo sapiens
19 GJD3  
Proximity Label-MS Homo sapiens
20 LAMP2 3920
Proximity Label-MS Homo sapiens
21 DNAJC25 548645
Proximity Label-MS Homo sapiens
22 CD79A  
Two-hybrid Homo sapiens
23 PTPN1 5770
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SYVN1 84447
Affinity Capture-MS Homo sapiens
25 ASPH 444
Co-fractionation Homo sapiens
26 STX4 6810
Proximity Label-MS Homo sapiens
27 FFAR1  
Affinity Capture-MS Homo sapiens
28 NDUFS2 4720
Two-hybrid Homo sapiens
29 DNAJB6 10049
Affinity Capture-MS Homo sapiens
30 LRPPRC 10128
Co-fractionation Homo sapiens
31 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
32 POTEE 445582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NNT 23530
Co-fractionation Homo sapiens
34 SYNGR1 9145
Affinity Capture-MS Homo sapiens
35 MGST1 4257
Co-fractionation Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 NDUFS3 4722
Co-fractionation Homo sapiens
38 SLC30A8  
Two-hybrid Homo sapiens
39 NDUFB8 4714
Co-fractionation Homo sapiens
40 COPS6 10980
Two-hybrid Homo sapiens
41 CCR2  
Two-hybrid Homo sapiens
42 STIM2 57620
Affinity Capture-MS Homo sapiens
43 RCN2 5955
Co-fractionation Homo sapiens
44 RAB3B 5865
Proximity Label-MS Homo sapiens
45 MGST3 4259
Two-hybrid Homo sapiens
46 GNB2 2783
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SSR1 6745
Proximity Label-MS Homo sapiens
48 ARMCX3 51566
Co-fractionation Homo sapiens
49 LONP1 9361
Co-fractionation Homo sapiens
50 DDOST 1650
Affinity Capture-MS Homo sapiens
51 RNASEK  
Two-hybrid Homo sapiens
52 ABHD5 51099
Affinity Capture-MS Homo sapiens
53 PGD 5226
Co-fractionation Homo sapiens
54 NDUFA8 4702
Co-fractionation Homo sapiens
55 LACTB 114294
Co-fractionation Homo sapiens
56 ITFG3 83986
Affinity Capture-MS Homo sapiens
57 CCDC47 57003
Affinity Capture-MS Homo sapiens
58 EEF1G 1937
Two-hybrid Homo sapiens
59 NDUFV1 4723
Co-fractionation Homo sapiens
60 IVD 3712
Co-fractionation Homo sapiens
61 F2RL1  
Two-hybrid Homo sapiens
62 C10orf107  
Affinity Capture-MS Homo sapiens
63 ANLN 54443
Affinity Capture-MS Homo sapiens
64 SNX7 51375
Two-hybrid Homo sapiens
65 RAB35 11021
Proximity Label-MS Homo sapiens
66 GPX8 493869
Two-hybrid Homo sapiens
67 SSMEM1  
Two-hybrid Homo sapiens
68 METTL7A 25840
Proximity Label-MS Homo sapiens
69 PRPH2 5961
Affinity Capture-MS Homo sapiens
70 MICA 100507436
Affinity Capture-MS Homo sapiens
71 LMAN1 3998
Proximity Label-MS Homo sapiens
72 KIAA1715 80856
Proximity Label-MS Homo sapiens
73 PXMP2  
Proximity Label-MS Homo sapiens
74 RAB5A 5868
Proximity Label-MS Homo sapiens
75 SMO 6608
Two-hybrid Homo sapiens
76 GPRASP1  
Two-hybrid Homo sapiens
77 LMNB1 4001
Proximity Label-MS Homo sapiens
78 P4HA1 5033
Co-fractionation Homo sapiens
79 ALG2 85365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 EMD 2010
Proximity Label-MS Homo sapiens
81 PHB 5245
Co-fractionation Homo sapiens
82 CXADR 1525
Proximity Label-MS Homo sapiens
83 STOM 2040
Two-hybrid Homo sapiens
84 UGT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 A2M 2
Two-hybrid Homo sapiens
86 KCNJ6  
Two-hybrid Homo sapiens
87 LRIF1  
Two-hybrid Homo sapiens
88 TUFM 7284
Co-fractionation Homo sapiens
89 LAPTM5 7805
Two-hybrid Homo sapiens
90 GIT1 28964
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
91 GPR152  
Two-hybrid Homo sapiens
92 JADE1  
Two-hybrid Homo sapiens
93 VCP 7415
Co-fractionation Homo sapiens
94 NKRF 55922
Two-hybrid Homo sapiens
95 ACADM 34
Co-fractionation Homo sapiens
96 LAMP1 3916
Proximity Label-MS Homo sapiens
97 FH 2271
Co-fractionation Homo sapiens
98 LMF2 91289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 DHFRL1  
Proximity Label-MS Homo sapiens
100 VMA21  
Two-hybrid Homo sapiens
101 ITFG1 81533
Two-hybrid Homo sapiens
102 UQCRH 7388
Co-fractionation Homo sapiens
103 AGPS 8540
Co-fractionation Homo sapiens
104 ELOVL5 60481
Proximity Label-MS Homo sapiens
105 SEC61B 10952
Proximity Label-MS Homo sapiens
106 ATP5B 506
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
107 KIF18A  
Affinity Capture-MS Homo sapiens
108 ZFP28  
Two-hybrid Homo sapiens
109 SQRDL 58472
Co-fractionation Homo sapiens
110 REEP5 7905
Proximity Label-MS Homo sapiens
111 DUSP22  
Affinity Capture-MS Homo sapiens
112 HAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
113 SEC63 11231
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 TAP1 6890
Affinity Capture-MS Homo sapiens
115 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 SGPL1 8879
Two-hybrid Homo sapiens
117 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
118 RPN2 6185
Proximity Label-MS Homo sapiens
119 ENDOD1 23052
Affinity Capture-MS Homo sapiens
120 CANX 821
Co-fractionation Homo sapiens
121 EMC8 10328
Co-fractionation Homo sapiens
122 LRRC59 55379
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
123 PANX1 24145
Proximity Label-MS Homo sapiens
124 NR3C1 2908
Two-hybrid Homo sapiens
125 UQCRC2 7385
Co-fractionation Homo sapiens
126 GGH 8836
Affinity Capture-MS Homo sapiens
127 EEF2 1938
Co-fractionation Homo sapiens
128 MARCH8  
Affinity Capture-MS Homo sapiens
129 ERGIC3 51614
Two-hybrid Homo sapiens
130 BCAP31 10134
Proximity Label-MS Homo sapiens
131 HSD3B7 80270
Proximity Label-MS Homo sapiens
132 HDDC3  
Affinity Capture-MS Homo sapiens
133 SYT6  
Affinity Capture-MS Homo sapiens
134 STIM1 6786
Proximity Label-MS Homo sapiens
135 MTNR1A  
Two-hybrid Homo sapiens
136 ARF6 382
Proximity Label-MS Homo sapiens
137 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 KIAA1377  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
139 PI4K2A 55361
Affinity Capture-MS Homo sapiens
140 CORO1C 23603
Co-fractionation Homo sapiens
141 ECHS1 1892
Co-fractionation Homo sapiens
142 PLXNB2 23654
Two-hybrid Homo sapiens
143 CYP2C18  
Affinity Capture-MS Homo sapiens
144 CD27  
Affinity Capture-MS Homo sapiens
145 FAM209A 200232
Two-hybrid Homo sapiens
146 INPP5K 51763
Two-hybrid Homo sapiens
147 FAM134C 162427
Two-hybrid Homo sapiens
148 WRB 7485
Two-hybrid Homo sapiens
149 ATP2A1 487
Proximity Label-MS Homo sapiens
150 EMC2 9694
Co-fractionation Homo sapiens
151 CYC1 1537
Co-fractionation Homo sapiens
152 RAB9A 9367
Proximity Label-MS Homo sapiens
153 USP19 10869
Affinity Capture-MS Homo sapiens
154 UQCRC1 7384
Co-fractionation Homo sapiens
155 COL10A1  
Affinity Capture-MS Homo sapiens
156 TGFA  
Affinity Capture-MS Homo sapiens
157 DUSP9  
Affinity Capture-MS Homo sapiens
158 RPN1 6184
Proximity Label-MS Homo sapiens
159 PVR 5817
Affinity Capture-MS Homo sapiens
160 TMEM214 54867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 CYP2C9  
Proximity Label-MS Homo sapiens
162 NDUFV2 4729
Co-fractionation Homo sapiens
163 LMNA 4000
Proximity Label-MS Homo sapiens
164 RTN4 57142
Affinity Capture-MS Homo sapiens
165 AKAP1 8165
Proximity Label-MS Homo sapiens
166 SNX5 27131
Two-hybrid Homo sapiens
167 RBBP4 5928
Two-hybrid Homo sapiens
168 TMX2 51075
Two-hybrid Homo sapiens
169 OST4  
Affinity Capture-MS Homo sapiens
170 ALDH9A1 223
Co-fractionation Homo sapiens
171 IMMT 10989
Two-hybrid Homo sapiens
172 CRB3 92359
Two-hybrid Homo sapiens
173 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
174 PHB2 11331
Co-fractionation Homo sapiens
175 TRIM13  
Affinity Capture-MS Homo sapiens
176 EIF3C 8663
Two-hybrid Homo sapiens
177 NCEH1 57552
Affinity Capture-MS Homo sapiens
178 PRAF2 11230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 BLOC1S2 282991
Two-hybrid Homo sapiens
180 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 LDLRAD1  
Affinity Capture-MS Homo sapiens
182 MED31  
Two-hybrid Homo sapiens
183 ZNF746  
Two-hybrid Homo sapiens
184 SMC4 10051
Cross-Linking-MS (XL-MS) Homo sapiens
185 ASIC4  
Affinity Capture-MS Homo sapiens
186 BCKDHA 593
Co-fractionation Homo sapiens
187 RTN3 10313
Affinity Capture-MS Homo sapiens
188 PDHA1 5160
Co-fractionation Homo sapiens
189 CCR1  
Affinity Capture-MS Homo sapiens
190 TSPAN15 23555
Affinity Capture-MS Homo sapiens
191 PTRH2 51651
Affinity Capture-MS Homo sapiens
192 NDUFS7 374291
Co-fractionation Homo sapiens
193 PDHB 5162
Co-fractionation Homo sapiens
194 EBP  
Two-hybrid Homo sapiens
195 ERGIC1 57222
Proximity Label-MS Homo sapiens
196 ATP2A2 488
Co-fractionation Homo sapiens
197 ELOVL4  
Two-hybrid Homo sapiens
198 WIF1 11197
Affinity Capture-MS Homo sapiens
199 EVA1C  
Affinity Capture-MS Homo sapiens
200 ERGIC2 51290
Proximity Label-MS Homo sapiens
201 NDUFS8 4728
Co-fractionation Homo sapiens
202 TEX264 51368
Affinity Capture-MS Homo sapiens
203 RAB2A 5862
Proximity Label-MS Homo sapiens
204 ARL13B 200894
Two-hybrid Homo sapiens
205 SEC62 7095
Proximity Label-MS Homo sapiens
206 GP5 2814
Affinity Capture-MS Homo sapiens
207 ATP6V1E1 529
Co-fractionation Homo sapiens
208 RAB7A 7879
Proximity Label-MS Homo sapiens
209 RAB11A 8766
Proximity Label-MS Homo sapiens
210 GPC3 2719
Affinity Capture-MS Homo sapiens
211 LPAR2 9170
Affinity Capture-MS Homo sapiens
212 ACAA2 10449
Co-fractionation Homo sapiens
213 VAMP5 10791
Affinity Capture-MS Homo sapiens
214 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 DNAJC1 64215
Proximity Label-MS Homo sapiens
216 RAB5C 5878
Proximity Label-MS Homo sapiens
217 FAM210B  
Two-hybrid Homo sapiens
218 CKAP4 10970
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
219 HLA-C 3107
Affinity Capture-MS Homo sapiens
220 PTGER4  
Two-hybrid Homo sapiens
221 SKA2  
Two-hybrid Homo sapiens
222 CPT1A 1374
Co-fractionation Homo sapiens
223 SHC1 6464
Two-hybrid Homo sapiens
224 DERL1 79139
Proximity Label-MS Homo sapiens
225 CEBPZ  
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here