Gene description for CHMP7
Gene name charged multivesicular body protein 7
Gene symbol CHMP7
Other names/aliases -
Species Homo sapiens
 Database cross references - CHMP7
ExoCarta ExoCarta_91782
Vesiclepedia VP_91782
Entrez Gene 91782
HGNC 28439
MIM 611130
UniProt Q8WUX9  
 CHMP7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CHMP7
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    plasma membrane repair GO:0001778 IDA
    vesicle budding from membrane GO:0006900 IBA
    autophagy GO:0006914 IMP
    nucleus organization GO:0006997 IMP
    mitotic metaphase chromosome alignment GO:0007080 IMP
    exit from mitosis GO:0010458 IMP
    protein transport GO:0015031 IEA
    nuclear membrane reassembly GO:0031468 IMP
    nuclear membrane reassembly GO:0031468 TAS
    late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 IBA
    multivesicular body assembly GO:0036258 NAS
    viral budding via host ESCRT complex GO:0039702 IDA
    viral budding via host ESCRT complex GO:0039702 NAS
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IDA
    late endosome to vacuole transport GO:0045324 IMP
    viral budding from plasma membrane GO:0046761 IDA
    vesicle fusion with vacuole GO:0051469 NAS
    multivesicular body-lysosome fusion GO:0061763 NAS
    midbody abscission GO:0061952 IMP
    protein localization to chromatin GO:0071168 IMP
    multivesicular body sorting pathway GO:0071985 IDA
    membrane fission GO:0090148 NAS
    autophagosome maturation GO:0097352 IMP
    regulation of mitotic spindle assembly GO:1901673 IMP
    late endosome to lysosome transport GO:1902774 IMP
    ESCRT III complex disassembly GO:1904903 NAS
Subcellular Localization
    autophagosome membrane GO:0000421 IDA
    kinetochore GO:0000776 IDA
    chromatin GO:0000785 IDA
    ESCRT III complex GO:0000815 IBA
    ESCRT III complex GO:0000815 IDA
    ESCRT III complex GO:0000815 NAS
    nuclear envelope GO:0005635 IDA
    nuclear pore GO:0005643 IDA
    nucleoplasm GO:0005654 IDA
    lysosomal membrane GO:0005765 IDA
    multivesicular body GO:0005771 IBA
    kinetochore microtubule GO:0005828 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    cytoplasmic side of plasma membrane GO:0009898 IBA
    midbody GO:0030496 IDA
    multivesicular body membrane GO:0032585 IDA
    amphisome membrane GO:1904930 IDA
 Experiment description of studies that identified CHMP7 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CHMP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REEP5 7905
Proximity Label-MS Homo sapiens
2 ARHGAP17 55114
Co-fractionation Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 RAB9A 9367
Proximity Label-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 NUP54 53371
Affinity Capture-MS Homo sapiens
7 C8orf33 65265
Affinity Capture-MS Homo sapiens
8 DNAJC25 548645
Proximity Label-MS Homo sapiens
9 MTCH1 23787
Proximity Label-MS Homo sapiens
10 LAMP2 3920
Proximity Label-MS Homo sapiens
11 RPN2 6185
Proximity Label-MS Homo sapiens
12 PAFAH1B3 5050
Two-hybrid Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 MARCKS 4082
Proximity Label-MS Homo sapiens
15 LAMP3  
Proximity Label-MS Homo sapiens
16 XPO1 7514
Affinity Capture-MS Homo sapiens
17 RAB4A 5867
Proximity Label-MS Homo sapiens
18 KIAA1715 80856
Proximity Label-MS Homo sapiens
19 PXMP2  
Proximity Label-MS Homo sapiens
20 LRRC59 55379
Proximity Label-MS Homo sapiens
21 MEX3A  
Affinity Capture-RNA Homo sapiens
22 MTCH2 23788
Proximity Label-MS Homo sapiens
23 BCAP31 10134
Proximity Label-MS Homo sapiens
24 HSD3B7 80270
Proximity Label-MS Homo sapiens
25 STIM1 6786
Proximity Label-MS Homo sapiens
26 HSD17B11 51170
Proximity Label-MS Homo sapiens
27 EMD 2010
Proximity Label-MS Homo sapiens
28 USP14 9097
Co-fractionation Homo sapiens
29 FKBP8 23770
Proximity Label-MS Homo sapiens
30 TRIM55  
Two-hybrid Homo sapiens
31 ARF6 382
Proximity Label-MS Homo sapiens
32 PTPN1 5770
Proximity Label-MS Homo sapiens
33 ERGIC1 57222
Proximity Label-MS Homo sapiens
34 OCIAD1 54940
Proximity Label-MS Homo sapiens
35 NXF1 10482
Affinity Capture-RNA Homo sapiens
36 TUFM 7284
Co-fractionation Homo sapiens
37 RAB5A 5868
Proximity Label-MS Homo sapiens
38 ERGIC2 51290
Proximity Label-MS Homo sapiens
39 USP8 9101
Reconstituted Complex Homo sapiens
40 CAV1 857
Proximity Label-MS Homo sapiens
41 FIS1 51024
Proximity Label-MS Homo sapiens
42 MOV10 4343
Affinity Capture-RNA Homo sapiens
43 SEC62 7095
Proximity Label-MS Homo sapiens
44 ATP2A1 487
Proximity Label-MS Homo sapiens
45 OGT 8473
Reconstituted Complex Homo sapiens
46 RAB11A 8766
Proximity Label-MS Homo sapiens
47 B3GAT1  
Proximity Label-MS Homo sapiens
48 TRIM63  
Two-hybrid Homo sapiens
49 RAB3B 5865
Proximity Label-MS Homo sapiens
50 CREB3  
Two-hybrid Homo sapiens
51 RPN1 6184
Proximity Label-MS Homo sapiens
52 DNAJC1 64215
Proximity Label-MS Homo sapiens
53 RAB5C 5878
Proximity Label-MS Homo sapiens
54 STX4 6810
Proximity Label-MS Homo sapiens
55 WDR12 55759
Co-fractionation Homo sapiens
56 SSR1 6745
Proximity Label-MS Homo sapiens
57 CKAP4 10970
Proximity Label-MS Homo sapiens
58 DERL1 79139
Proximity Label-MS Homo sapiens
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 RHOT2 89941
Proximity Label-MS Homo sapiens
61 ELOVL5 60481
Proximity Label-MS Homo sapiens
62 AKAP1 8165
Proximity Label-MS Homo sapiens
63 SEC61B 10952
Proximity Label-MS Homo sapiens
64 EXD2  
Proximity Label-MS Homo sapiens
65 RMDN3 55177
Proximity Label-MS Homo sapiens
66 SLC25A46 91137
Proximity Label-MS Homo sapiens
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