Gene description for C2CD2L
Gene name C2CD2-like
Gene symbol C2CD2L
Other names/aliases DLNB23
TMEM24
Species Homo sapiens
 Database cross references - C2CD2L
ExoCarta ExoCarta_9854
Vesiclepedia VP_9854
Entrez Gene 9854
HGNC 29000
UniProt O14523  
 C2CD2L identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for C2CD2L
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol transfer activity GO:0008526 IBA
    phosphatidylinositol transfer activity GO:0008526 IDA
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IDA
    insulin binding GO:0043559 IEA
Biological Process
    phospholipid transport GO:0015914 IEA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IBA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP
    intermembrane lipid transfer GO:0120009 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IDA
    cortical endoplasmic reticulum GO:0032541 IDA
    cytoplasmic side of apical plasma membrane GO:0098592 IBA
    cytoplasmic side of apical plasma membrane GO:0098592 IDA
    endoplasmic reticulum-plasma membrane contact site GO:0140268 IDA
 Experiment description of studies that identified C2CD2L in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for C2CD2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 ICOSLG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SLC10A6  
Two-hybrid Homo sapiens
4 VAPA 9218
Affinity Capture-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
7 NRSN1  
Affinity Capture-MS Homo sapiens
8 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MFSD5  
Two-hybrid Homo sapiens
10 CD79A  
Two-hybrid Homo sapiens
11 FSHR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TMEM179B 374395
Two-hybrid Homo sapiens
13 TMPRSS2 7113
Two-hybrid Homo sapiens
14 CHODL 140578
Two-hybrid Homo sapiens
15 BRWD3  
Affinity Capture-MS Homo sapiens
16 OPRM1 4988
Two-hybrid Homo sapiens
17 MUC1 4582
Two-hybrid Homo sapiens
18 STX7 8417
Proximity Label-MS Homo sapiens
19 YWHAG 7532
Affinity Capture-MS Homo sapiens
20 ACVR2B  
Affinity Capture-MS Homo sapiens
21 C3orf52  
Affinity Capture-MS Homo sapiens
22 IL17RA 23765
Affinity Capture-MS Homo sapiens
23 RAB35 11021
Proximity Label-MS Homo sapiens
24 SDCBP 6386
Two-hybrid Homo sapiens
25 NUP155 9631
Proximity Label-MS Homo sapiens
26 FCER1G 2207
Two-hybrid Homo sapiens
27 TMEM14B  
Two-hybrid Homo sapiens
28 EMD 2010
Proximity Label-MS Homo sapiens
29 REEP4  
Two-hybrid Homo sapiens
30 SCAP  
Affinity Capture-MS Homo sapiens
31 MCAM 4162
Proximity Label-MS Homo sapiens
32 PCDHB11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PCDHGC4  
Affinity Capture-MS Homo sapiens
34 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GJB1 2705
Two-hybrid Homo sapiens
36 RPN1 6184
Proximity Label-MS Homo sapiens
37 IL17RC 84818
Affinity Capture-MS Homo sapiens
38 BTNL3  
Affinity Capture-MS Homo sapiens
39 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ELOVL5 60481
Proximity Label-MS Homo sapiens
41 SEC61B 10952
Proximity Label-MS Homo sapiens
42 PCDHGB2  
Affinity Capture-MS Homo sapiens
43 RMDN3 55177
Proximity Label-MS Homo sapiens
44 PCDHA8  
Affinity Capture-MS Homo sapiens
45 KCNS3 3790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 GJA8  
Two-hybrid Homo sapiens
47 PCDHGB1  
Affinity Capture-MS Homo sapiens
48 PCDHB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RPN2 6185
Proximity Label-MS Homo sapiens
50 LRRC59 55379
Proximity Label-MS Homo sapiens
51 ZDHHC12  
Affinity Capture-MS Homo sapiens
52 PCDHAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CLRN1  
Two-hybrid Homo sapiens
54 BCAP31 10134
Proximity Label-MS Homo sapiens
55 HSD3B7 80270
Proximity Label-MS Homo sapiens
56 STIM1 6786
Proximity Label-MS Homo sapiens
57 TMEM86B  
Two-hybrid Homo sapiens
58 PRKCQ 5588
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ABTB2 25841
Affinity Capture-MS Homo sapiens
60 ATP2A1 487
Proximity Label-MS Homo sapiens
61 HIBADH 11112
Two-hybrid Homo sapiens
62 PDZK1IP1 10158
Two-hybrid Homo sapiens
63 EVA1B 55194
Affinity Capture-MS Homo sapiens
64 PCDHA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RHOB 388
Proximity Label-MS Homo sapiens
66 TMX2 51075
Two-hybrid Homo sapiens
67 PCDHAC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CXCR3  
Two-hybrid Homo sapiens
69 TMEM9 252839
Two-hybrid Homo sapiens
70 KCNA2  
Affinity Capture-MS Homo sapiens
71 UMODL1  
Affinity Capture-MS Homo sapiens
72 ARL13B 200894
Two-hybrid Homo sapiens
73 EBP  
Two-hybrid Homo sapiens
74 REEP2  
Two-hybrid Homo sapiens
75 DDX58 23586
Affinity Capture-RNA Homo sapiens
76 IL3RA  
Two-hybrid Homo sapiens
77 MARCH4  
Affinity Capture-MS Homo sapiens
78 SEC62 7095
Proximity Label-MS Homo sapiens
79 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CNGA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PCDHB16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 CISD2 493856
Two-hybrid Homo sapiens
83 KRAS 3845
Proximity Label-MS Homo sapiens
84 TMEM31  
Two-hybrid Homo sapiens
85 CKAP4 10970
Proximity Label-MS Homo sapiens
86 DERL1 79139
Proximity Label-MS Homo sapiens
87 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C2CD2L is involved
No pathways found





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