Gene description for SEC24A
Gene name SEC24 family member A
Gene symbol SEC24A
Other names/aliases -
Species Homo sapiens
 Database cross references - SEC24A
ExoCarta ExoCarta_10802
Entrez Gene 10802
HGNC 10703
MIM 607183
UniProt O95486  
 SEC24A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SEC24A
Molecular Function
    molecular_function GO:0003674 ND
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein secretion GO:0050714 IEA
    COPII vesicle coating GO:0048208 TAS
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    intracellular protein transport GO:0006886 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    membrane organization GO:0061024 TAS
    small molecule metabolic process GO:0044281 TAS
    regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045714 IEA
    positive regulation of cholesterol homeostasis GO:2000189 IEA
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    ER to Golgi vesicle-mediated transport GO:0006888 TAS
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    COPII vesicle coat GO:0030127 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 TAS
    ER to Golgi transport vesicle membrane GO:0012507 TAS
 Experiment description of studies that identified SEC24A in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEC24A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Two-hybrid Homo sapiens
View the network image/svg+xml



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