Gene description for CAMLG
Gene name calcium modulating ligand
Gene symbol CAMLG
Other names/aliases CAML
Species Homo sapiens
 Database cross references - CAMLG
ExoCarta ExoCarta_819
Vesiclepedia VP_819
Entrez Gene 819
HGNC 1471
MIM 601118
UniProt P49069  
 CAMLG identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CAMLG
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    B cell homeostasis GO:0001782 ISS
    receptor recycling GO:0001881 IEA
    defense response GO:0006952 TAS
    signal transduction GO:0007165 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    vesicle-mediated transport GO:0016192 IEA
    negative regulation of protein ubiquitination GO:0031397 IMP
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IMP
    protein insertion into ER membrane GO:0045048 NAS
    protein stabilization GO:0050821 IDA
    protein stabilization GO:0050821 IMP
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IBA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IDA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 HDA
    GET complex GO:0043529 IBA
    GET complex GO:0043529 IDA
    GET complex GO:0043529 IPI
 Experiment description of studies that identified CAMLG in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CAMLG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F11R 50848
Two-hybrid Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 RNF122  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 VAPA 9218
Affinity Capture-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 DNAJC16  
Proximity Label-MS Homo sapiens
9 TMUB1  
Affinity Capture-Western Homo sapiens
10 GJD3  
Proximity Label-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 DNAJC25 548645
Proximity Label-MS Homo sapiens
13 TXNDC12 51060
Two-hybrid Homo sapiens
14 PTPN1 5770
Proximity Label-MS Homo sapiens
15 STX4 6810
Proximity Label-MS Homo sapiens
16 CCDC90B  
Proximity Label-MS Homo sapiens
17 ETNK1  
Two-hybrid Homo sapiens
18 B3GAT1  
Proximity Label-MS Homo sapiens
19 RAB3B 5865
Proximity Label-MS Homo sapiens
20 STX7 8417
Proximity Label-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 TBC1D15 64786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 STX6 10228
Proximity Label-MS Homo sapiens
24 SLC25A46 91137
Proximity Label-MS Homo sapiens
25 TNFRSF13B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
26 RAB35 11021
Proximity Label-MS Homo sapiens
27 MARCKS 4082
Proximity Label-MS Homo sapiens
28 LMAN1 3998
Proximity Label-MS Homo sapiens
29 NUP155 9631
Proximity Label-MS Homo sapiens
30 KIAA1715 80856
Proximity Label-MS Homo sapiens
31 PXMP2  
Proximity Label-MS Homo sapiens
32 RAB5A 5868
Proximity Label-MS Homo sapiens
33 PANX1 24145
Proximity Label-MS Homo sapiens
34 PPIB 5479
Two-hybrid Homo sapiens
35 EMD 2010
Proximity Label-MS Homo sapiens
36 CXADR 1525
Proximity Label-MS Homo sapiens
37 HSP90B1 7184
Two-hybrid Homo sapiens
38 RAB4A 5867
Proximity Label-MS Homo sapiens
39 ASNA1 439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
40 PBXIP1 57326
Two-hybrid Homo sapiens
41 AGR2 10551
Two-hybrid Homo sapiens
42 DHFRL1  
Proximity Label-MS Homo sapiens
43 RHOT2 89941
Proximity Label-MS Homo sapiens
44 ELOVL5 60481
Proximity Label-MS Homo sapiens
45 SEC61B 10952
Proximity Label-MS Homo sapiens
46 RMDN3 55177
Proximity Label-MS Homo sapiens
47 REEP5 7905
Proximity Label-MS Homo sapiens
48 SEC63 11231
Proximity Label-MS Homo sapiens
49 LAT 27040
Two-hybrid Homo sapiens
50 RPN2 6185
Proximity Label-MS Homo sapiens
51 LRRC59 55379
Proximity Label-MS Homo sapiens
52 LMNB1 4001
Proximity Label-MS Homo sapiens
53 LAMP1 3916
Proximity Label-MS Homo sapiens
54 CRELD1 78987
Affinity Capture-MS Homo sapiens
55 BCAP31 10134
Proximity Label-MS Homo sapiens
56 HSD3B7 80270
Proximity Label-MS Homo sapiens
57 STIM1 6786
Proximity Label-MS Homo sapiens
58 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
59 FKBP8 23770
Proximity Label-MS Homo sapiens
60 ARF6 382
Proximity Label-MS Homo sapiens
61 VWC2  
Two-hybrid Homo sapiens
62 OCIAD1 54940
Two-hybrid Homo sapiens
63 WRB 7485
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
64 ATP2A1 487
Proximity Label-MS Homo sapiens
65 RAB9A 9367
Proximity Label-MS Homo sapiens
66 RPN1 6184
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
67 CYP2C9  
Proximity Label-MS Homo sapiens
68 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
69 LCN2 3934
Two-hybrid Homo sapiens
70 RNF43  
Proximity Label-MS Homo sapiens
71 KCNA2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 SIDT2 51092
Affinity Capture-MS Homo sapiens
73 PGRMC1 10857
Two-hybrid Homo sapiens
74 ERGIC1 57222
Proximity Label-MS Homo sapiens
75 ERGIC2 51290
Proximity Label-MS Homo sapiens
76 ADIPOQ 9370
Two-hybrid Homo sapiens
77 SEC62 7095
Proximity Label-MS Homo sapiens
78 RAB7A 7879
Proximity Label-MS Homo sapiens
79 RAB11A 8766
Proximity Label-MS Homo sapiens
80 TPST2 8459
Affinity Capture-MS Homo sapiens
81 DNAJC1 64215
Proximity Label-MS Homo sapiens
82 KRAS 3845
Proximity Label-MS Homo sapiens
83 RAB5C 5878
Proximity Label-MS Homo sapiens
84 TMEM31  
Two-hybrid Homo sapiens
85 CKAP4 10970
Proximity Label-MS Homo sapiens
86 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 KCNE4  
Two-hybrid Homo sapiens
88 DERL1 79139
Proximity Label-MS Homo sapiens
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