Gene description for CCDC115
Gene name coiled-coil domain containing 115
Gene symbol CCDC115
Other names/aliases ccp1
Species Homo sapiens
 Database cross references - CCDC115
ExoCarta ExoCarta_84317
Vesiclepedia VP_84317
Entrez Gene 84317
HGNC 28178
MIM 613734
UniProt Q96NT0  
 CCDC115 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CCDC115
Molecular Function
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 IBA
Biological Process
    intracellular iron ion homeostasis GO:0006879 IMP
    lysosomal lumen acidification GO:0007042 IMP
    cellular response to increased oxygen levels GO:0036295 IMP
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 IEA
    lysosomal protein catabolic process GO:1905146 IMP
Subcellular Localization
    lysosome GO:0005764 IEA
    endosome GO:0005768 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    membrane GO:0016020 HDA
    vacuolar proton-transporting V-type ATPase complex GO:0016471 IDA
    COPI-coated vesicle GO:0030137 IDA
 Experiment description of studies that identified CCDC115 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CCDC115
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 SEC63 11231
Proximity Label-MS Homo sapiens
4 Tmed2 56334
Affinity Capture-MS Mus musculus
5 ATP6V0A4 50617
Affinity Capture-MS Homo sapiens
6 RNF40 9810
Affinity Capture-MS Homo sapiens
7 DNAJC25 548645
Proximity Label-MS Homo sapiens
8 CSNK2B 1460
Two-hybrid Homo sapiens
9 SCYL3 57147
Affinity Capture-MS Homo sapiens
10 Spast  
Affinity Capture-MS Mus musculus
11 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SIDT2 51092
Affinity Capture-MS Homo sapiens
13 KIF14 9928
Affinity Capture-MS Homo sapiens
14 METTL7A 25840
Proximity Label-MS Homo sapiens
15 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ALOX15B  
Two-hybrid Homo sapiens
17 KIAA2013 90231
Affinity Capture-MS Homo sapiens
18 GPR12  
Affinity Capture-MS Homo sapiens
19 LAMP1 3916
Proximity Label-MS Homo sapiens
20 TPTE  
Proximity Label-MS Homo sapiens
21 Bmpr1a  
Affinity Capture-MS Mus musculus
22 Chmp4b 75608
Affinity Capture-MS Mus musculus
23 GOLT1B 51026
Affinity Capture-MS Homo sapiens
24 PRKCZ 5590
Two-hybrid Homo sapiens
25 TMEM199  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TSPAN17 26262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TMEM88  
Affinity Capture-MS Homo sapiens
28 MIS18A  
Two-hybrid Homo sapiens
29 FKBP8 23770
Proximity Label-MS Homo sapiens
30 GPR114  
Affinity Capture-MS Homo sapiens
31 PTPN1 5770
Proximity Label-MS Homo sapiens
32 COPE 11316
Affinity Capture-MS Homo sapiens
33 TMEM63C  
Affinity Capture-MS Homo sapiens
34 APP 351
Reconstituted Complex Homo sapiens
35 ATP6V1F 9296
Affinity Capture-MS Homo sapiens
36 TCIRG1 10312
Affinity Capture-MS Homo sapiens
37 ABI2 10152
Two-hybrid Homo sapiens
38 ATP6V0E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATP6V0C 527
Affinity Capture-MS Homo sapiens
40 BZW2 28969
Affinity Capture-MS Homo sapiens
41 COPB2 9276
Affinity Capture-MS Homo sapiens
42 C3orf18  
Affinity Capture-MS Homo sapiens
43 PRC1 9055
Affinity Capture-MS Homo sapiens
44 PCDHGC4  
Affinity Capture-MS Homo sapiens
45 WDYHV1  
Two-hybrid Homo sapiens
46 RAB7A 7879
Affinity Capture-MS Homo sapiens
47 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
48 LPAR2 9170
Affinity Capture-MS Homo sapiens
49 PLK1 5347
Two-hybrid Homo sapiens
50 TGFA  
Affinity Capture-MS Homo sapiens
51 PLXDC2 84898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MUC1 4582
Affinity Capture-MS Homo sapiens
54 DNAJC1 64215
Proximity Label-MS Homo sapiens
55 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
56 RARS 5917
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
57 CLTC 1213
Affinity Capture-MS Homo sapiens
58 MICAL1 64780
Affinity Capture-MS Homo sapiens
59 GPR113  
Affinity Capture-MS Homo sapiens
60 VAV1 7409
Affinity Capture-MS Homo sapiens
61 RHOT2 89941
Proximity Label-MS Homo sapiens
62 MTUS2 23281
Affinity Capture-MS Homo sapiens
63 SEC61B 10952
Proximity Label-MS Homo sapiens
64 ATP6V0D2 245972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CCDC8  
Affinity Capture-MS Homo sapiens
66 RMDN3 55177
Proximity Label-MS Homo sapiens
67 SLC25A46 91137
Proximity Label-MS Homo sapiens
68 TK1 7083
Two-hybrid Homo sapiens
View the network image/svg+xml



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