Gene description for TEX264
Gene name testis expressed 264
Gene symbol TEX264
Other names/aliases ZSIG11
Species Homo sapiens
 Database cross references - TEX264
ExoCarta ExoCarta_51368
Vesiclepedia VP_51368
Entrez Gene 51368
HGNC 30247
UniProt Q9Y6I9  
 TEX264 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TEX264
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IDA
Biological Process
    reticulophagy GO:0061709 IBA
    reticulophagy GO:0061709 IDA
    reticulophagy GO:0061709 IMP
    protein-DNA covalent cross-linking repair GO:0106300 IBA
    protein-DNA covalent cross-linking repair GO:0106300 IDA
Subcellular Localization
    autophagosome membrane GO:0000421 IBA
    autophagosome membrane GO:0000421 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    replication fork GO:0005657 IBA
    replication fork GO:0005657 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IDA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified TEX264 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TEX264
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEMA4C 54910
Affinity Capture-MS Homo sapiens
2 HMOX1 3162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LHFPL4  
Two-hybrid Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 PER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 EMP1  
Two-hybrid Homo sapiens
11 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 JPH1 56704
Affinity Capture-MS Homo sapiens
13 CTDNEP1 23399
Affinity Capture-MS Homo sapiens
14 MAN1B1 11253
Affinity Capture-MS Homo sapiens
15 GJD3  
Proximity Label-MS Homo sapiens
16 MAP4K4 9448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 DNAJC25 548645
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
19 PTPN1 5770
Proximity Label-MS Homo sapiens
20 STX4 6810
Proximity Label-MS Homo sapiens
21 MS4A3  
Two-hybrid Homo sapiens
22 FFAR3  
Two-hybrid Homo sapiens
23 APEX1 328
Affinity Capture-RNA Homo sapiens
24 VANGL2  
Affinity Capture-MS Homo sapiens
25 PLEKHG4  
Affinity Capture-MS Homo sapiens
26 B3GAT1  
Proximity Label-MS Homo sapiens
27 COPB2 9276
Affinity Capture-MS Homo sapiens
28 RAB3B 5865
Proximity Label-MS Homo sapiens
29 OPRM1 4988
Two-hybrid Homo sapiens
30 PNPLA6 10908
Affinity Capture-MS Homo sapiens
31 SSR1 6745
Proximity Label-MS Homo sapiens
32 PIGH  
Affinity Capture-MS Homo sapiens
33 PLD2 5338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DNAJC16  
Proximity Label-MS Homo sapiens
35 SLC25A46 91137
Proximity Label-MS Homo sapiens
36 SNX14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RAB35 11021
Proximity Label-MS Homo sapiens
38 CSNK1D 1453
Affinity Capture-MS Homo sapiens
39 CEP131 22994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MARCKS 4082
Proximity Label-MS Homo sapiens
41 LMAN1 3998
Proximity Label-MS Homo sapiens
42 SMIM3  
Two-hybrid Homo sapiens
43 NUP155 9631
Proximity Label-MS Homo sapiens
44 KIAA1715 80856
Proximity Label-MS Homo sapiens
45 PXMP2  
Proximity Label-MS Homo sapiens
46 RAB5A 5868
Proximity Label-MS Homo sapiens
47 CD70 970
Affinity Capture-MS Homo sapiens
48 PANX1 24145
Proximity Label-MS Homo sapiens
49 MTCH2 23788
Affinity Capture-MS Homo sapiens
50 EVA1C  
Affinity Capture-MS Homo sapiens
51 TYW1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SHISA3  
Affinity Capture-MS Homo sapiens
53 EMD 2010
Proximity Label-MS Homo sapiens
54 TBL2 26608
Affinity Capture-MS Homo sapiens
55 FOXK1 221937
Affinity Capture-MS Homo sapiens
56 CXADR 1525
Proximity Label-MS Homo sapiens
57 PLD1 5337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GPR97  
Two-hybrid Homo sapiens
59 PREB 10113
Affinity Capture-MS Homo sapiens
60 MCM10 55388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PCDHGC4  
Affinity Capture-MS Homo sapiens
62 GDPD5 81544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 RAB7A 7879
Proximity Label-MS Homo sapiens
64 GJB1 2705
Two-hybrid Homo sapiens
65 RPN1 6184
Proximity Label-MS Homo sapiens
66 CSNK1E 1454
Affinity Capture-MS Homo sapiens
67 ARL13B 200894
Two-hybrid Homo sapiens
68 LHFPL5  
Two-hybrid Homo sapiens
69 ELOVL5 60481
Proximity Label-MS Homo sapiens
70 MFF 56947
Two-hybrid Homo sapiens
71 ABCC10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CACNG4  
Affinity Capture-MS Homo sapiens
74 RMDN3 55177
Proximity Label-MS Homo sapiens
75 CLN6  
Two-hybrid Homo sapiens
76 REEP5 7905
Proximity Label-MS Homo sapiens
77 SEC63 11231
Proximity Label-MS Homo sapiens
78 MINK1 50488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 RPN2 6185
Proximity Label-MS Homo sapiens
81 ICAM2 3384
Affinity Capture-MS Homo sapiens
82 FFAR2  
Two-hybrid Homo sapiens
83 LRRC59 55379
Proximity Label-MS Homo sapiens
84 LMNB1 4001
Proximity Label-MS Homo sapiens
85 POTEI 653269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 TM4SF18  
Two-hybrid Homo sapiens
87 HMOX2 3163
Affinity Capture-MS Homo sapiens
88 TMEM9B 56674
Affinity Capture-MS Homo sapiens
89 SLC35F2 54733
Affinity Capture-MS Homo sapiens
90 BCAP31 10134
Proximity Label-MS Homo sapiens
91 HSD3B7 80270
Proximity Label-MS Homo sapiens
92 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 DIP2A 23181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 STIM1 6786
Proximity Label-MS Homo sapiens
95 SLC34A2 10568
Two-hybrid Homo sapiens
96 FKBP8 23770
Proximity Label-MS Homo sapiens
97 SLC10A2  
Two-hybrid Homo sapiens
98 CHEK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ENTPD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 CREB3L1  
Two-hybrid Homo sapiens
101 GPR152  
Two-hybrid Homo sapiens
102 FAM209A 200232
Two-hybrid Homo sapiens
103 MAPK6  
Affinity Capture-MS Homo sapiens
104 GPR42  
Two-hybrid Homo sapiens
105 STAT1 6772
Affinity Capture-MS Homo sapiens
106 ATP2A1 487
Proximity Label-MS Homo sapiens
107 RAB9A 9367
Proximity Label-MS Homo sapiens
108 DHFRL1  
Proximity Label-MS Homo sapiens
109 ENTPD2 954
Affinity Capture-MS Homo sapiens
110 ISLR 3671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
112 OSBPL8 114882
Affinity Capture-MS Homo sapiens
113 TSPAN12  
Two-hybrid Homo sapiens
114 CLDN2 9075
Two-hybrid Homo sapiens
115 SUN1 23353
Affinity Capture-MS Homo sapiens
116 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
117 TERF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 C1orf43 25912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
120 CUEDC1 404093
Affinity Capture-MS Homo sapiens
121 TALDO1 6888
Cross-Linking-MS (XL-MS) Homo sapiens
122 EDEM1  
Affinity Capture-MS Homo sapiens
123 PDE3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NUP35 129401
Proximity Label-MS Homo sapiens
125 ERGIC1 57222
Proximity Label-MS Homo sapiens
126 PDZD8 118987
Affinity Capture-MS Homo sapiens
127 DNAJC14  
Proximity Label-MS Homo sapiens
128 ERGIC2 51290
Proximity Label-MS Homo sapiens
129 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 SEC62 7095
Proximity Label-MS Homo sapiens
131 TMEM79  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
132 LRRC61 65999
Affinity Capture-MS Homo sapiens
133 RAB11A 8766
Proximity Label-MS Homo sapiens
134 SERBP1 26135
Affinity Capture-MS Homo sapiens
135 DNAJC1 64215
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
136 RAB5C 5878
Proximity Label-MS Homo sapiens
137 TMEM31  
Two-hybrid Homo sapiens
138 CCDC47 57003
Affinity Capture-MS Homo sapiens
139 CKAP4 10970
Proximity Label-MS Homo sapiens
140 DERL1 79139
Proximity Label-MS Homo sapiens
141 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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