Gene description for WWOX
Gene name WW domain containing oxidoreductase
Gene symbol WWOX
Other names/aliases D16S432E
EIEE28
FOR
FRA16D
HHCMA56
PRO0128
SCAR12
SDR41C1
WOX1
Species Homo sapiens
 Database cross references - WWOX
ExoCarta ExoCarta_51741
Vesiclepedia VP_51741
Entrez Gene 51741
HGNC 12799
MIM 605131
UniProt Q9NZC7  
 WWOX identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for WWOX
Molecular Function
    transcription coactivator activity GO:0003713 ISS
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 NAS
    enzyme binding GO:0019899 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    osteoblast differentiation GO:0001649 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    skeletal system morphogenesis GO:0048705 ISS
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISS
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 ISS
    lysosome GO:0005764 IEA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    microvillus GO:0005902 IDA
    RNA polymerase II transcription regulator complex GO:0090575 ISS
 Experiment description of studies that identified WWOX in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for WWOX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF3A 8661
Affinity Capture-MS Homo sapiens
2 WDR91 29062
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 DGCR14  
Affinity Capture-MS Homo sapiens
5 ATG9A 79065
Proximity Label-MS Homo sapiens
6 FKBP15 23307
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DDX17 10521
Affinity Capture-MS Homo sapiens
8 SMARCE1 6605
Affinity Capture-MS Homo sapiens
9 KRT4 3851
Affinity Capture-MS Homo sapiens
10 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
11 SCAF4 57466
Affinity Capture-MS Homo sapiens
12 FBRS 64319
Affinity Capture-MS Homo sapiens
13 ATN1  
Affinity Capture-MS Homo sapiens
14 GNE 10020
Two-hybrid Homo sapiens
15 PSMB8 5696
Two-hybrid Homo sapiens
16 AMOTL1 154810
Affinity Capture-MS Homo sapiens
17 LONP2 83752
Affinity Capture-MS Homo sapiens
18 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
19 C11orf87  
Two-hybrid Homo sapiens
20 USP6NL 9712
Affinity Capture-MS Homo sapiens
21 MPP5 64398
Affinity Capture-MS Homo sapiens
22 APBB2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
23 USP39 10713
Affinity Capture-MS Homo sapiens
24 PLAC8  
Two-hybrid Homo sapiens
25 CPSF7 79869
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
26 DCTPP1 79077
Affinity Capture-MS Homo sapiens
27 MARCH5  
Proximity Label-MS Homo sapiens
28 OTUD7B 56957
Affinity Capture-MS Homo sapiens
29 SNRPD3 6634
Affinity Capture-MS Homo sapiens
30 SLC25A46 91137
Proximity Label-MS Homo sapiens
31 POLR2C 5432
Affinity Capture-MS Homo sapiens
32 ZNF598 90850
Affinity Capture-MS Homo sapiens
33 WBP2 23558
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
34 RBMX 27316
Affinity Capture-MS Homo sapiens
35 FARSA 2193
Affinity Capture-MS Homo sapiens
36 NEDD9 4739
Two-hybrid Homo sapiens
37 HN1L 90861
Affinity Capture-MS Homo sapiens
38 TSGA10IP  
Two-hybrid Homo sapiens
39 CAPZA1 829
Affinity Capture-MS Homo sapiens
40 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CSTF2 1478
Affinity Capture-MS Homo sapiens
42 SRSF3 6428
Affinity Capture-MS Homo sapiens
43 DAZAP2  
Two-hybrid Homo sapiens
44 PABPC1 26986
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
45 CDH1 999
Proximity Label-MS Homo sapiens
46 ALDH3A1 218
Affinity Capture-MS Homo sapiens
47 OGT 8473
Affinity Capture-MS Homo sapiens
48 SLC15A2 6565
Two-hybrid Homo sapiens
49 TCHP  
Two-hybrid Homo sapiens
50 C10orf55  
Two-hybrid Homo sapiens
51 MYH16  
Affinity Capture-MS Homo sapiens
52 ENO1 2023
Affinity Capture-MS Homo sapiens
53 MED25  
Two-hybrid Homo sapiens
54 ZNF581  
Two-hybrid Homo sapiens
55 VENTX  
Two-hybrid Homo sapiens
56 DDX39B 7919
Affinity Capture-MS Homo sapiens
57 CSTF3 1479
Affinity Capture-MS Homo sapiens
58 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 MPDZ  
Affinity Capture-MS Homo sapiens
60 PDCD7  
Affinity Capture-MS Homo sapiens
61 SRPK1 6732
Affinity Capture-MS Homo sapiens
62 U2SURP 23350
Affinity Capture-MS Homo sapiens
63 FAM189B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PKLR 5313
Affinity Capture-MS Homo sapiens
65 RBM39 9584
Affinity Capture-MS Homo sapiens
66 HADHA 3030
Affinity Capture-MS Homo sapiens
67 ANXA1 301
Affinity Capture-MS Homo sapiens
68 BCAP31 10134
Proximity Label-MS Homo sapiens
69 YWHAZ 7534
Affinity Capture-MS Homo sapiens
70 ERBB4 2066
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 PRMT5 10419
Affinity Capture-MS Homo sapiens
72 SF3B6 51639
Affinity Capture-MS Homo sapiens
73 HSPA1A 3303
Affinity Capture-MS Homo sapiens
74 HSPA4 3308
Affinity Capture-MS Homo sapiens
75 PRPF40A 55660
Affinity Capture-MS Homo sapiens
76 ACY1 95
Two-hybrid Homo sapiens
77 CYP2C9  
Proximity Label-MS Homo sapiens
78 CSDE1 7812
Affinity Capture-MS Homo sapiens
79 PABPC3 5042
Affinity Capture-MS Homo sapiens
80 CXorf57  
Affinity Capture-MS Homo sapiens
81 CRNN 49860
Affinity Capture-MS Homo sapiens
82 NOSIP 51070
Affinity Capture-MS Homo sapiens
83 NUDT21 11051
Reconstituted Complex Homo sapiens
84 DVL1 1855
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
85 FASN 2194
Negative Genetic Homo sapiens
86 WDR77 79084
Affinity Capture-MS Homo sapiens
87 VOPP1  
Affinity Capture-MS Homo sapiens
88 WWOX 51741
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 TCERG1 10915
Reconstituted Complex Homo sapiens
90 SCAF8 22828
Affinity Capture-MS Homo sapiens
91 SMN2 6607
Affinity Capture-MS Homo sapiens
92 MYH1  
Affinity Capture-MS Homo sapiens
93 CPSF2 53981
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
94 PRPF31 26121
Affinity Capture-MS Homo sapiens
95 LATS1  
Protein-peptide Homo sapiens
96 GORASP1 64689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 ATAD3A 55210
Affinity Capture-MS Homo sapiens
98 IK 3550
Affinity Capture-MS Homo sapiens
99 DDR1 780
Affinity Capture-MS Homo sapiens
100 HSPB2-C11orf52  
Two-hybrid Homo sapiens
101 TRIM69 140691
Two-hybrid Homo sapiens
102 EPHA2 1969
Proximity Label-MS Homo sapiens
103 RAB5C 5878
Proximity Label-MS Homo sapiens
104 ANXA2 302
Affinity Capture-MS Homo sapiens
105 IFIT2 3433
Two-hybrid Homo sapiens
106 LRP3  
Affinity Capture-MS Homo sapiens
107 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
108 LYZ 4069
Affinity Capture-MS Homo sapiens
109 METTL7A 25840
Proximity Label-MS Homo sapiens
110 LAMP3  
Proximity Label-MS Homo sapiens
111 GJA1 2697
Proximity Label-MS Homo sapiens
112 TARDBP 23435
Affinity Capture-MS Homo sapiens
113 THRAP3 9967
Affinity Capture-MS Homo sapiens
114 SF3B1 23451
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
115 NOP56 10528
Affinity Capture-MS Homo sapiens
116 ATM 472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 LZTS3  
Affinity Capture-MS Homo sapiens
118 PBX4  
Two-hybrid Homo sapiens
119 SMR3A  
Two-hybrid Homo sapiens
120 DIAPH1 1729
Affinity Capture-MS Homo sapiens
121 KRT3 3850
Two-hybrid Homo sapiens
122 NOLC1 9221
Affinity Capture-MS Homo sapiens
123 CPSF1 29894
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
124 SEC24C 9632
Affinity Capture-MS Homo sapiens
125 ANAPC11  
Two-hybrid Homo sapiens
126 RPN2 6185
Proximity Label-MS Homo sapiens
127 PTPN14 5784
Affinity Capture-MS Homo sapiens
128 DDX6 1656
Affinity Capture-MS Homo sapiens
129 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CREB5 9586
Two-hybrid Homo sapiens
131 AMOT  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
132 FAM154A  
Two-hybrid Homo sapiens
133 LMAN1 3998
Proximity Label-MS Homo sapiens
134 CCT2 10576
Affinity Capture-MS Homo sapiens
135 SYMPK 8189
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
136 PRPF8 10594
Affinity Capture-MS Homo sapiens
137 DDX21 9188
Affinity Capture-MS Homo sapiens
138 DRG1 4733
Affinity Capture-MS Homo sapiens
139 ACIN1 22985
Affinity Capture-MS Homo sapiens
140 SNRNP200 23020
Affinity Capture-MS Homo sapiens
141 SNRPD1 6632
Affinity Capture-MS Homo sapiens
142 ABHD11 83451
Two-hybrid Homo sapiens
143 DCAF7 10238
Affinity Capture-MS Homo sapiens
144 ACAT2 39
Two-hybrid Homo sapiens
145 PATL1 219988
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
146 PREB 10113
Affinity Capture-MS Homo sapiens
147 AGPS 8540
Proximity Label-MS Homo sapiens
148 BDH2 56898
Affinity Capture-MS Homo sapiens
149 IQSEC1 9922
Affinity Capture-MS Homo sapiens
150 KHSRP 8570
Affinity Capture-MS Homo sapiens
151 ACLY 47
Affinity Capture-MS Homo sapiens
152 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 DHX36 170506
Affinity Capture-MS Homo sapiens
154 UBAP2 55833
Affinity Capture-MS Homo sapiens
155 POLR2E 5434
Affinity Capture-MS Homo sapiens
156 WDR33 55339
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
157 ATP5F1 515
Affinity Capture-MS Homo sapiens
158 YLPM1 56252
Affinity Capture-MS Homo sapiens
159 HSD17B10 3028
Affinity Capture-MS Homo sapiens
160 FUS 2521
Affinity Capture-MS Homo sapiens
161 HOXA1 3198
Two-hybrid Homo sapiens
162 KLHDC7B  
Two-hybrid Homo sapiens
163 TFG 10342
Two-hybrid Homo sapiens
164 KDM3B  
Affinity Capture-MS Homo sapiens
165 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
166 ATP2A1 487
Affinity Capture-MS Homo sapiens
167 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
168 SHC3  
Two-hybrid Homo sapiens
169 SH2D4A 63898
Two-hybrid Homo sapiens
170 HUWE1 10075
Affinity Capture-MS Homo sapiens
171 DSP 1832
Affinity Capture-MS Homo sapiens
172 C17orf80 55028
Proximity Label-MS Homo sapiens
173 PRRC2A 7916
Affinity Capture-MS Homo sapiens
174 TOE1 114034
Affinity Capture-MS Homo sapiens
175 DIDO1  
Affinity Capture-MS Homo sapiens
176 TP53 7157
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
177 CTAG1B  
Two-hybrid Homo sapiens
178 SPG20 23111
Affinity Capture-MS Homo sapiens
179 HNRNPK 3190
Reconstituted Complex Homo sapiens
180 DCD 117159
Affinity Capture-MS Homo sapiens
181 ERGIC2 51290
Proximity Label-MS Homo sapiens
182 ABI2 10152
Two-hybrid Homo sapiens
183 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
184 KRT34  
Two-hybrid Homo sapiens
185 CPSF3 51692
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
186 PITX2  
Two-hybrid Homo sapiens
187 WIPF2 147179
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
188 FRS3 10817
Two-hybrid Homo sapiens
189 C19orf54  
Two-hybrid Homo sapiens
190 RARRES3  
Affinity Capture-MS Homo sapiens
191 HSD17B11 51170
Proximity Label-MS Homo sapiens
192 XRN2 22803
Affinity Capture-MS Homo sapiens
193 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
194 HNRNPR 10236
Affinity Capture-MS Homo sapiens
195 ZNF414  
Two-hybrid Homo sapiens
196 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
197 DROSHA  
Affinity Capture-MS Homo sapiens
198 ZBTB33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 TRIM28 10155
Affinity Capture-Western Homo sapiens
200 DAZAP1 26528
Affinity Capture-MS Homo sapiens
201 SSR1 6745
Proximity Label-MS Homo sapiens
202 SF3A2 8175
Affinity Capture-MS Homo sapiens
203 PGD 5226
Affinity Capture-MS Homo sapiens
204 DSG3 1830
Affinity Capture-MS Homo sapiens
205 ATRX 546
Co-localization Homo sapiens
206 CSNK2B 1460
Two-hybrid Homo sapiens
207 TEX37  
Two-hybrid Homo sapiens
208 PABPC4 8761
Affinity Capture-MS Homo sapiens
209 CYYR1  
Affinity Capture-MS Homo sapiens
210 HSPA8 3312
Affinity Capture-MS Homo sapiens
211 NUP155 9631
Proximity Label-MS Homo sapiens
212 PXMP2  
Proximity Label-MS Homo sapiens
213 FAM222B  
Two-hybrid Homo sapiens
214 VEZF1  
Two-hybrid Homo sapiens
215 P4HA1 5033
Affinity Capture-MS Homo sapiens
216 FOXD4L1  
Two-hybrid Homo sapiens
217 ZMAT5  
Affinity Capture-MS Homo sapiens
218 LRRC10  
Affinity Capture-MS Homo sapiens
219 GLIS2  
Two-hybrid Homo sapiens
220 GOLGA2 2801
Proximity Label-MS Homo sapiens
221 FAM103A1  
Two-hybrid Homo sapiens
222 DHFRL1  
Proximity Label-MS Homo sapiens
223 DHX9 1660
Affinity Capture-MS Homo sapiens
224 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
225 SF3A3 10946
Affinity Capture-MS Homo sapiens
226 POLR2B 5431
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
227 SF3B2 10992
Affinity Capture-MS Homo sapiens
228 TTYH1  
Affinity Capture-MS Homo sapiens
229 DDX3Y 8653
Affinity Capture-MS Homo sapiens
230 KLHL38  
Two-hybrid Homo sapiens
231 FOXI1  
Two-hybrid Homo sapiens
232 RPRD2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
233 HSD3B7 80270
Proximity Label-MS Homo sapiens
234 TNK2 10188
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
235 DHX30 22907
Affinity Capture-MS Homo sapiens
236 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
237 CYFIP2 26999
Affinity Capture-MS Homo sapiens
238 TP73  
Affinity Capture-MS Homo sapiens
239 SERPINB5 5268
Affinity Capture-MS Homo sapiens
240 OTX1  
Two-hybrid Homo sapiens
241 OCIAD1 54940
Proximity Label-MS Homo sapiens
242 A2ML1 144568
Affinity Capture-MS Homo sapiens
243 LACRT 90070
Affinity Capture-MS Homo sapiens
244 MTOR 2475
Affinity Capture-Western Homo sapiens