Gene description for EMC7
Gene name ER membrane protein complex subunit 7
Gene symbol EMC7
Other names/aliases C11orf3
C15orf24
HT022
ORF1-FL1
Species Homo sapiens
 Database cross references - EMC7
ExoCarta ExoCarta_56851
Vesiclepedia VP_56851
Entrez Gene 56851
HGNC 24301
UniProt Q9NPA0  
 EMC7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EMC7
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    membrane insertase activity GO:0032977 IMP
Biological Process
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IDA
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IMP
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 IDA
    membrane GO:0016020 NAS
    EMC complex GO:0072546 IBA
    EMC complex GO:0072546 IDA
    EMC complex GO:0072546 IPI
    EMC complex GO:0072546 ISS
 Experiment description of studies that identified EMC7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EMC7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 EMC2 9694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GNA12 2768
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 SYNGR1 9145
Affinity Capture-MS Homo sapiens
6 CD164L2  
Affinity Capture-MS Homo sapiens
7 ATP13A2  
Two-hybrid Homo sapiens
8 TMED5 50999
Affinity Capture-MS Homo sapiens
9 SUB1 10923
Affinity Capture-MS Homo sapiens
10 TMEM95  
Affinity Capture-MS Homo sapiens
11 DNAJC25 548645
Proximity Label-MS Homo sapiens
12 KRTAP5-9  
Two-hybrid Homo sapiens
13 PTPN1 5770
Proximity Label-MS Homo sapiens
14 CD200 4345
Affinity Capture-MS Homo sapiens
15 Emc3  
Affinity Capture-MS Mus musculus
16 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TMED2 10959
Affinity Capture-MS Homo sapiens
18 DNAJC16  
Proximity Label-MS Homo sapiens
19 TMEM140  
Affinity Capture-MS Homo sapiens
20 SLC25A46 91137
Proximity Label-MS Homo sapiens
21 KLK6 5653
Affinity Capture-MS Homo sapiens
22 CA14 23632
Affinity Capture-MS Homo sapiens
23 NOTCH2NL 388677
Two-hybrid Homo sapiens
24 KRTAP5-2  
Two-hybrid Homo sapiens
25 EMC1 23065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 EMC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MDH2 4191
Cross-Linking-MS (XL-MS) Homo sapiens
28 PXMP2  
Proximity Label-MS Homo sapiens
29 ENPP6 133121
Affinity Capture-MS Homo sapiens
30 EMC10 284361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PGAM5 192111
Co-fractionation Homo sapiens
32 TMEM55B 90809
Affinity Capture-MS Homo sapiens
33 OR4N2  
Affinity Capture-MS Homo sapiens
34 TSPAN3 10099
Affinity Capture-MS Homo sapiens
35 DEFB106A  
Affinity Capture-MS Homo sapiens
36 SDF2L1 23753
Affinity Capture-MS Homo sapiens
37 CYSRT1 375791
Two-hybrid Homo sapiens
38 APOA2 336
Affinity Capture-MS Homo sapiens
39 GPR182  
Affinity Capture-MS Homo sapiens
40 SLC4A8 9498
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SLC28A2  
Affinity Capture-MS Homo sapiens
42 MEOX2  
Two-hybrid Homo sapiens
43 RPN1 6184
Proximity Label-MS Homo sapiens
44 DNAJC30  
Proximity Label-MS Homo sapiens
45 CCDC47 57003
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SEC61B 10952
Proximity Label-MS Homo sapiens
47 DNAJB11 51726
Proximity Label-MS Homo sapiens
48 ZACN  
Affinity Capture-MS Homo sapiens
49 RMDN3 55177
Proximity Label-MS Homo sapiens
50 OR2S2  
Affinity Capture-MS Homo sapiens
51 P2RX4 5025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SEC63 11231
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
53 TM4SF20  
Affinity Capture-MS Homo sapiens
54 HSPA5 3309
Proximity Label-MS Homo sapiens
55 VIPR2  
Affinity Capture-MS Homo sapiens
56 TMED9 54732
Affinity Capture-MS Homo sapiens
57 EMC3 55831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 RPN2 6185
Proximity Label-MS Homo sapiens
59 CANX 821
Affinity Capture-MS Homo sapiens
60 RAB7A 7879
Proximity Label-MS Homo sapiens
61 EMC8 10328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 LRRC59 55379
Proximity Label-MS Homo sapiens
63 UBQLN2 29978
Affinity Capture-MS Homo sapiens
64 Emc6  
Affinity Capture-MS Mus musculus
65 BCAP31 10134
Proximity Label-MS Homo sapiens
66 MTNR1A  
Two-hybrid Homo sapiens
67 EGFR 1956
Negative Genetic Homo sapiens
68 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SCGB1C1  
Affinity Capture-MS Homo sapiens
70 Emc1 230866
Affinity Capture-MS Mus musculus
71 C3orf18  
Affinity Capture-MS Homo sapiens
72 RPA3 6119
Proximity Label-MS Homo sapiens
73 ATP2A1 487
Proximity Label-MS Homo sapiens
74 FBXO2 26232
Affinity Capture-MS Homo sapiens
75 ATP1B3 483
Affinity Capture-MS Homo sapiens
76 NCLN 56926
Affinity Capture-MS Homo sapiens
77 DNAJC3 5611
Proximity Label-MS Homo sapiens
78 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
79 ENTPD2 954
Affinity Capture-MS Homo sapiens
80 IFNA21  
Affinity Capture-MS Homo sapiens
81 MARCH6  
Affinity Capture-MS Homo sapiens
82 EMC6 83460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 SEL1L3  
Affinity Capture-MS Homo sapiens
84 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
85 TMED10 10972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 SLC18A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 RTN3 10313
Affinity Capture-MS Homo sapiens
88 PDIA4 9601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 SAA1 6288
Affinity Capture-MS Homo sapiens
90 CD1B 910
Affinity Capture-MS Homo sapiens
91 NBPF19  
Two-hybrid Homo sapiens
92 EMC4 51234
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 KRTAP1-1  
Two-hybrid Homo sapiens
94 MMGT1 93380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SCN4A  
Affinity Capture-MS Homo sapiens
96 GPR6  
Affinity Capture-MS Homo sapiens
97 SEC62 7095
Proximity Label-MS Homo sapiens
98 TMEM79  
Affinity Capture-MS Homo sapiens
99 SPPL2B 56928
Affinity Capture-MS Homo sapiens
100 ADCY2 108
Affinity Capture-MS Homo sapiens
101 CD151 977
Affinity Capture-MS Homo sapiens
102 LPAR2 9170
Affinity Capture-MS Homo sapiens
103 KLHL22 84861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 TMED7 51014
Affinity Capture-MS Homo sapiens
105 DNAJC1 64215
Proximity Label-MS Homo sapiens
106 KRAS 3845
Negative Genetic Homo sapiens
107 SLC8A3  
Affinity Capture-MS Homo sapiens
108 PLAC9 219348
Affinity Capture-MS Homo sapiens
109 DERL1 79139
Proximity Label-MS Homo sapiens
110 DNAJC22  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EMC7 is involved
No pathways found





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