Gene description for VEZT
Gene name vezatin, adherens junctions transmembrane protein
Gene symbol VEZT
Other names/aliases VEZATIN
Species Homo sapiens
 Database cross references - VEZT
ExoCarta ExoCarta_55591
Vesiclepedia VP_55591
Entrez Gene 55591
HGNC 18258
UniProt Q9HBM0  
 VEZT identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for VEZT
Molecular Function
    myosin binding GO:0017022 IEA
Biological Process
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    stereocilia ankle link complex GO:0002142 ISS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    adherens junction GO:0005912 IEA
    stereocilium membrane GO:0060171 IEA
 Experiment description of studies that identified VEZT in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for VEZT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 METTL7A 25840
Proximity Label-MS Homo sapiens
4 LAMP3  
Proximity Label-MS Homo sapiens
5 GJA1 2697
Proximity Label-MS Homo sapiens
6 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DNAJC16  
Proximity Label-MS Homo sapiens
8 TRIM66  
Affinity Capture-MS Homo sapiens
9 CTDNEP1 23399
Proximity Label-MS Homo sapiens
10 GJD3  
Proximity Label-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 DNAJC25 548645
Proximity Label-MS Homo sapiens
13 PTPN1 5770
Proximity Label-MS Homo sapiens
14 STX4 6810
Proximity Label-MS Homo sapiens
15 BTN3A1 11119
Affinity Capture-MS Homo sapiens
16 B3GAT1  
Proximity Label-MS Homo sapiens
17 C11orf87  
Affinity Capture-MS Homo sapiens
18 OR6T1  
Affinity Capture-MS Homo sapiens
19 RAB3B 5865
Proximity Label-MS Homo sapiens
20 ACTR1A 10121
Proximity Label-MS Homo sapiens
21 KLRC1  
Affinity Capture-MS Homo sapiens
22 SSR1 6745
Proximity Label-MS Homo sapiens
23 STX6 10228
Proximity Label-MS Homo sapiens
24 SLC25A46 91137
Proximity Label-MS Homo sapiens
25 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
26 RAB35 11021
Proximity Label-MS Homo sapiens
27 GPR17 2840
Affinity Capture-MS Homo sapiens
28 MARCKS 4082
Proximity Label-MS Homo sapiens
29 CCDC114  
Affinity Capture-MS Homo sapiens
30 FAS 355
Proximity Label-MS Homo sapiens
31 LMAN1 3998
Proximity Label-MS Homo sapiens
32 NUP155 9631
Proximity Label-MS Homo sapiens
33 KIAA1715 80856
Proximity Label-MS Homo sapiens
34 PXMP2  
Proximity Label-MS Homo sapiens
35 RAB5A 5868
Proximity Label-MS Homo sapiens
36 TMED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 CXADR 1525
Proximity Label-MS Homo sapiens
39 MAPRE1 22919
Affinity Capture-MS Homo sapiens
40 RAB4A 5867
Proximity Label-MS Homo sapiens
41 CDH1 999
Affinity Capture-Western Homo sapiens
42 RPA2 6118
Proximity Label-MS Homo sapiens
43 S100A11 6282
Affinity Capture-MS Homo sapiens
44 CTNNB1 1499
Affinity Capture-Western Homo sapiens
45 IPPK  
Affinity Capture-MS Homo sapiens
46 PLEKHO2 80301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RPN1 6184
Proximity Label-MS Homo sapiens
48 RHOT2 89941
Proximity Label-MS Homo sapiens
49 ELOVL5 60481
Proximity Label-MS Homo sapiens
50 SEC61B 10952
Proximity Label-MS Homo sapiens
51 RMDN3 55177
Proximity Label-MS Homo sapiens
52 REEP5 7905
Proximity Label-MS Homo sapiens
53 SEC63 11231
Proximity Label-MS Homo sapiens
54 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CXCR4 7852
Affinity Capture-MS Homo sapiens
56 RPN2 6185
Proximity Label-MS Homo sapiens
57 LRRC59 55379
Proximity Label-MS Homo sapiens
58 PANX1 24145
Proximity Label-MS Homo sapiens
59 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 LAMP1 3916
Proximity Label-MS Homo sapiens
61 BCAP31 10134
Proximity Label-MS Homo sapiens
62 HSD3B7 80270
Proximity Label-MS Homo sapiens
63 MYO7A 4647
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
64 STIM1 6786
Proximity Label-MS Homo sapiens
65 FKBP8 23770
Proximity Label-MS Homo sapiens
66 ARF6 382
Proximity Label-MS Homo sapiens
67 PCDHGB2  
Affinity Capture-MS Homo sapiens
68 ATP2A1 487
Proximity Label-MS Homo sapiens
69 CMTM5  
Affinity Capture-MS Homo sapiens
70 RAB9A 9367
Proximity Label-MS Homo sapiens
71 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ACTB 60
Proximity Label-MS Homo sapiens
73 DHFRL1  
Proximity Label-MS Homo sapiens
74 CYP2C9  
Proximity Label-MS Homo sapiens
75 CTNNA1 1495
Affinity Capture-Western Homo sapiens
76 TSPAN10 83882
Affinity Capture-MS Homo sapiens
77 LRFN2  
Affinity Capture-MS Homo sapiens
78 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TPTE  
Proximity Label-MS Homo sapiens
80 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
82 ERGIC1 57222
Proximity Label-MS Homo sapiens
83 GPRC5D  
Affinity Capture-MS Homo sapiens
84 ERGIC2 51290
Proximity Label-MS Homo sapiens
85 Actr1b 226977
Affinity Capture-MS Mus musculus
86 RAB2A 5862
Proximity Label-MS Homo sapiens
87 SEC62 7095
Proximity Label-MS Homo sapiens
88 RAB7A 7879
Proximity Label-MS Homo sapiens
89 RAB11A 8766
Proximity Label-MS Homo sapiens
90 DNAJC1 64215
Proximity Label-MS Homo sapiens
91 KRAS 3845
Proximity Label-MS Homo sapiens
92 RAB5C 5878
Proximity Label-MS Homo sapiens
93 CKAP4 10970
Proximity Label-MS Homo sapiens
94 ANKRD46 157567
Affinity Capture-MS Homo sapiens
95 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VEZT is involved
No pathways found





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