Gene description for DSC3
Gene name desmocollin 3
Gene symbol DSC3
Other names/aliases CDHF3
DSC
DSC1
DSC2
DSC4
HT-CP
Species Homo sapiens
 Database cross references - DSC3
ExoCarta ExoCarta_1825
Entrez Gene 1825
HGNC 3037
MIM 600271
UniProt Q14574  
 DSC3 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for DSC3
Molecular Function
    calcium ion binding GO:0005509 IEA
    gamma-catenin binding GO:0045295 IPI
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    in utero embryonic development GO:0001701 IEA
    cell adhesion GO:0007155 TAS
    protein stabilization GO:0050821 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular region GO:0005576 IEA
    cell-cell junction GO:0005911 TAS
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 TAS
    desmosome GO:0030057 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified DSC3 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DSC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PKP4 8502
Two-hybrid Homo sapiens
2 PKP3 11187
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 JUP 3728
Affinity Capture-Western Homo sapiens
4 CTNNB1 1499
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DSC3 is involved
No pathways found





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