Gene description for VPS13A
Gene name vacuolar protein sorting 13 homolog A (S. cerevisiae)
Gene symbol VPS13A
Other names/aliases CHAC
CHOREIN
Species Homo sapiens
 Database cross references - VPS13A
ExoCarta ExoCarta_23230
Vesiclepedia VP_23230
Entrez Gene 23230
HGNC 1908
MIM 605978
UniProt Q96RL7  
 VPS13A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for VPS13A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein targeting to vacuole GO:0006623 IBA
    lipid transport GO:0006869 IEA
    Golgi to endosome transport GO:0006895 NAS
    autophagy GO:0006914 IBA
    autophagy GO:0006914 IMP
    protein localization GO:0008104 NAS
    adult locomotory behavior GO:0008344 IEA
    protein secretion GO:0009306 IEA
    gene expression GO:0010467 IEA
    microglia differentiation GO:0014004 IEA
    erythrocyte differentiation GO:0030218 IEA
    flagellated sperm motility GO:0030317 IEA
    sperm mitochondrion organization GO:0030382 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    social behavior GO:0035176 IEA
    multicellular organism growth GO:0035264 IEA
    exploration behavior GO:0035640 IEA
    protein retention in Golgi apparatus GO:0045053 IBA
    neuromuscular process controlling balance GO:0050885 IEA
    long-term synaptic depression GO:0060292 IEA
    motor behavior GO:0061744 IEA
    cellular response to osmotic stress GO:0071470 IEA
    response to environmental enrichment GO:0090648 IEA
    neuron projection arborization GO:0140058 IEA
    neuroinflammatory response GO:0150076 IEA
    lysosomal protein catabolic process GO:1905146 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial outer membrane GO:0005741 IDA
    lysosomal membrane GO:0005765 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi apparatus GO:0005794 ISS
    lipid droplet GO:0005811 IDA
    cytosol GO:0005829 IEA
    endosome membrane GO:0010008 IDA
    mitochondrial membrane GO:0031966 IDA
    neuron projection GO:0043005 IEA
    neuronal cell body GO:0043025 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
    sperm midpiece GO:0097225 IEA
    neuronal dense core vesicle lumen GO:0099013 ISS
 Experiment description of studies that identified VPS13A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VPS13A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
4 REEP5 7905
Proximity Label-MS Homo sapiens
5 VPS35 55737
Co-fractionation Homo sapiens
6 HSD17B11 51170
Proximity Label-MS Homo sapiens
7 RAB35 11021
Proximity Label-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 SSR1 6745
Proximity Label-MS Homo sapiens
10 CRTAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FGF14  
Affinity Capture-MS Homo sapiens
12 PPIAL4G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 UBXN4 23190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 EEF1A1 1915
Co-fractionation Homo sapiens
15 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
16 METTL7A 25840
Proximity Label-MS Homo sapiens
17 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MARCKS 4082
Proximity Label-MS Homo sapiens
19 PDE7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 GJA1 2697
Proximity Label-MS Homo sapiens
22 CALM2 805
Affinity Capture-MS Homo sapiens
23 RAB9A 9367
Proximity Label-MS Homo sapiens
24 ATP5H 10476
Cross-Linking-MS (XL-MS) Homo sapiens
25 SDK2 54549
Affinity Capture-MS Homo sapiens
26 CTDNEP1 23399
Proximity Label-MS Homo sapiens
27 ATG12  
Proximity Label-MS Homo sapiens
28 MTCH2 23788
Proximity Label-MS Homo sapiens
29 EDEM1  
Affinity Capture-MS Homo sapiens
30 HSD3B7 80270
Proximity Label-MS Homo sapiens
31 CALM3 808
Affinity Capture-MS Homo sapiens
32 NR3C1 2908
Proximity Label-MS Homo sapiens
33 NAT8B  
Affinity Capture-MS Homo sapiens
34 EMD 2010
Proximity Label-MS Homo sapiens
35 EGFR 1956
Affinity Capture-MS Homo sapiens
36 FKBP8 23770
Proximity Label-MS Homo sapiens
37 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DNAJC25 548645
Proximity Label-MS Homo sapiens
39 STX4 6810
Proximity Label-MS Homo sapiens
40 ELOVL5 60481
Proximity Label-MS Homo sapiens
41 LMAN1 3998
Proximity Label-MS Homo sapiens
42 LYN 4067
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
43 OCIAD1 54940
Proximity Label-MS Homo sapiens
44 GNAT2 2780
Affinity Capture-MS Homo sapiens
45 RAB4A 5867
Proximity Label-MS Homo sapiens
46 MTCH1 23787
Proximity Label-MS Homo sapiens
47 NUP210P1  
Affinity Capture-MS Homo sapiens
48 FIS1 51024
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAB2A 5862
Proximity Label-MS Homo sapiens
50 SEC62 7095
Proximity Label-MS Homo sapiens
51 RAB7A 7879
Proximity Label-MS Homo sapiens
52 RAB11A 8766
Proximity Label-MS Homo sapiens
53 CYB5R3 1727
Affinity Capture-MS Homo sapiens
54 MYO9B 4650
Cross-Linking-MS (XL-MS) Homo sapiens
55 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 RPN1 6184
Proximity Label-MS Homo sapiens
57 DNAJC1 64215
Proximity Label-MS Homo sapiens
58 KRAS 3845
Proximity Label-MS Homo sapiens
59 XKRX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RHOB 388
Proximity Label-MS Homo sapiens
61 TMEM31  
Affinity Capture-MS Homo sapiens
62 HAX1  
Proximity Label-MS Homo sapiens
63 ARPC5 10092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 POLR1D 51082
Affinity Capture-MS Homo sapiens
65 RAB5C 5878
Proximity Label-MS Homo sapiens
66 RABL2A 11159
Affinity Capture-MS Homo sapiens
67 SLC25A46 91137
Proximity Label-MS Homo sapiens
68 AKAP1 8165
Proximity Label-MS Homo sapiens
69 SEC61B 10952
Proximity Label-MS Homo sapiens
70 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RMDN3 55177
Proximity Label-MS Homo sapiens
72 ATG7 10533
Affinity Capture-Western Homo sapiens
73 VPS4B 9525
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which VPS13A is involved
No pathways found





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